Special Issue "Oxidative and Nitrosative Stress Related to Mitochondrial Dysfunction in Traumatic Brain Injury"
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (31 October 2020).
Interests: neurodegenerative acute (traumatic brain injury) and chronic (multiple sclerosis) disorders; oxidative and nitrosative stresses; oxidation mechanisms; antioxidants; metabolomics; biochemical analytical techniques; lipid peroxidation products; dietary antioxidants; carotenoids; polyphenols; vitamin E; vitamin C; antioxidant activity/capacity)
Interests: acute and chronic neurodegenerations; traumatic brain injury; multiple sclerosis; mitochondrial dysfunction ; microRNAs; biochemical analytical techniques
Interests: neurodegenerative acute (traumatic brain injury) and chronic (multiple sclerosis) disorders; oxidative and nitrosative stresses; oxidation mechanisms
Special Issues and Collections in MDPI journals
Special Issue in Life: Regulating Energy Balance: Uncovering the Involvement of Neurotrophins
Traumatic brain injury (TBI) remains one of the leading causes of morbidity and mortality amongst adults in Western countries. Despite advances in our knowledge of the complex pathophysiology of TBI, the underlying mechanisms are yet to be fully elucidated. This neurodegeneration consists of not only morphological damage but also a further, profound, hidden and somehow ‘invisible’ biochemical harm, initiated by the inertial forces acting on the brain tissue at the time of impact. These forces trigger a cascade of molecular events altering a plethora of cellular functions including ionic homeostasis, mitochondrial functions, energy metabolism, neurotransmission, signal transduction, protein folding, gene expression, and apoptosis. Various experimental studies have ultimately demonstrated that these and other changes are strictly related to severity of injury, in turn, related to the amount of the mechanical energy transferred at the time of impact, with mild TBI (mTBI) mostly causing spontaneously resolving changes, and with severe TBI (sTBI) mainly provoking permanent alterations of pivotal cerebral cell functions.
The shift of normal mitochondrial activity to pathological activity after TBI, lies in an initial functional-to-dysfunctional transition state causing, in turn, the activation of dangerous pathological reactions, potentially leading to definitive, irreversible mitochondrial damage. Reversing mitochondrial malfunctioning may be crucial to avoiding irreversible processes being triggered, such as apoptosis, thus, preventing the physiology-to-pathology shift.
In TBI, dysfunctional mitochondria are involved in the generation of oxidative/nitrosative stress, caused by the excess production of reactive oxygen and nitrogen species (ROS and RNS, respectively), as well as in the induction of apoptosis.
This Special Issue will publish original research papers and reviews that investigate the implications of mitochondrial dysfunction, oxidative stress, and dysmetabolic conditions after a TBI, as well as in preclinical and clinical studies.
We cordially invite scientists involved in base research to submit their original research or review manuscripts to this Special Issue on “Oxidative and Nitrosative Stress Related to Mitochondrial Dysfunction in Traumatic Brain Injury”.
Original research reports and reviews will be published online in Antioxidants.
Prof. Dr. Barbara Tavazzi
Prof. Giacomo Lazzarino
Prof. Angela Maria Amorini
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Traumatic brain injury
- Mitochondrial dysfunction
- Mitochondrial quality control
- Oxidative and nitrosative stresses
- Purines and pyrimidines metabolism
- Metabolism of amino acids and amino compounds
- Degrees of severity of TBI
- Brain imaging
- Serum biomarkers
- Secondary injury