Antioxidants from Agri-Food Byproducts: Effects on Metabolic Syndrome and Skin Health

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 374

Special Issue Editors


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NutraPharmaLab, Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano 59, 80131 Naples, Italy
Interests: nutraceuticals; bioactive compounds; antioxidant activity; mass spectrometry; chromatography
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Excellence of Pharmacy, University of Naples Federico II, Via D. Montesano, 49, 80131 Naples, Italy
Interests: cosmetics; transdermal absorption; nutricosmetics; skin analysis; analytical chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, increasing attention has been devoted to the recovery and valorization of agri-food byproducts as sustainable sources of bioactive compounds since many of these matrices are particularly rich in antioxidant molecules—including polyphenols, flavonoids, carotenoids, and sulfur-containing phytochemicals—which may exert beneficial effects on human health. Beyond their well-known antioxidant capacity, these compounds are emerging as promising agents in the prevention and management of metabolic disorders and skin-related conditions, where oxidative stress and inflammation play key pathogenic roles.

This Special Issue aims to collect original research articles, reviews, and short communications focused on antioxidants obtained from agri-food byproducts and their potential effects on metabolic and skin health. In particular, we welcome contributions addressing the identification and characterization of these compounds, their bioavailability and mechanisms of action, and their effects on biomarkers and pathways related to insulin resistance, dyslipidemia, obesity, inflammation, skin aging, barrier function, and oxidative damage. Contributions addressing the biological activities of these compounds, as well as innovative extraction strategies, advanced analytical and metabolomic approaches, bioinformatic tools for target prediction and pathway analysis, and the development of value-added products from food industry residues are also encouraged.

Dr. Vincenzo Piccolo
Dr. Maria Maisto
Dr. Ritamaria Di Lorenzo
Guest Editors

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Keywords

  • agri-food byproducts
  • antioxidants
  • bioactive compounds
  • oxidative stress
  • polyphenols
  • anti-inflammatory activity
  • skin health
  • cosmeceuticals
  • nutraceuticals
  • sustainable valorization

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Published Papers (1 paper)

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Research

17 pages, 10110 KB  
Article
Integrated Epithelial Models Reveal Anti-Inflammatory and Barrier Modulatory Properties of Ozoile in Inflammatory Bowel Disease
by Daniele Bravoco, Giuseppina di Paola, Valeria Lucci, Carlo Calabrese, Serena Vella, Domenico Montesano, Rosarita Tatè, Rebecca Leandri, Gionata De Vico, Salvatore Valiante, Teresa Barra, Geppino Falco, Giuliana Napolitano and Pellegrino Mazzone
Antioxidants 2026, 15(6), 664; https://doi.org/10.3390/antiox15060664 - 25 May 2026
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Abstract
Background: Inflammatory bowel disease (IBD) is a chronic inflammatory condition, with therapy-resistant patients undergoing surgery and a high risk of developing colorectal cancer. Novel therapeutic approaches have shown limited efficacy in IBD treatment, highlighting the need for safer and more personalized strategies. [...] Read more.
Background: Inflammatory bowel disease (IBD) is a chronic inflammatory condition, with therapy-resistant patients undergoing surgery and a high risk of developing colorectal cancer. Novel therapeutic approaches have shown limited efficacy in IBD treatment, highlighting the need for safer and more personalized strategies. The potential of natural compounds to modulate inflammation suggests their use as a potential adjunct therapy for IBD patients. Methods: Intestinal epithelial cells organoids (IECOs) were derived from IBD and non-IBD tissues from IBD patients, and levels of inflammation markers and epithelial barrier permeability were assayed using qRT-PCR, WB, IF and leaking assays in the presence of Ozoile, an extra virgin olive oil enriched in ozonides. The Luciferase-based IBD-like organoid platform was generated for preliminary screening of anti-inflammatory drugs. Results: In this study, we showed that IBD-ECOs recapitulate tissue architecture and pathological state. We showed that Ozoile has anti-inflammatory and epithelial barrier modulatory effects and that the Luciferase IBD-like organoid model is sensitive to anti-inflammatory compounds. Conclusions: Using IECOs, the specific anti-inflammatory and regenerative properties of Ozoile were assessed. Notably, our study highlights the potential of an IBD-like organoid platform to use in high-throughput screenings for rapid selection of anti-inflammatory drugs. Full article
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