Journal Menu► ▼ Journal Menu
Journal Browser► ▼ Journal Browser
Special Issue "The Importance of Thioredoxin System for Redox Regulation and Health"
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Antioxidant Enzyme Systems".
Deadline for manuscript submissions: closed (15 March 2023) | Viewed by 2318
Special Issue Editors
Interests: molecular mechanisms of toxicity; thioredoxin and glutaredoxin systems; cancer; mercury and methylmercury toxicity; environmental and human risk assessment; biomarkers & food safety
Special Issues, Collections and Topics in MDPI journals
2. Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz (IUEM), Quinta da Granja, Monte de Caparica, 2829-511 Caparica, Portugal
Interests: mercury toxicity; selenium and selenoproteins; redox active systems; mechanisms of toxicity
Special Issues, Collections and Topics in MDPI journals
Special Issue in International Journal of Environmental Research and Public Health: Xenobiotic Mixtures: A Complex Environmental and Human Health Issue
Special Issue in Processes: Current and Future Trends in Chemical Analysis of Food: Techniques and Applications
Special Issue Information
Thioredoxin system encompasses thioredoxin reductase (TrxR), thioredoxin (Trx) and NADPH and is central to the regulation of cell redox homeostasis. Trx was discovered 60 years ago as a hydrogen donor for the reduction of ribonucleotides by ribonucleotide reductase (RNR) and is fundamental for repairing oxidized proteins.
TrxR isoforms, TrxR1; TrxR2; TrxR3 also known as TGR, besides their importance to regenerate oxidized thioredoxin in cytoplasm and in mitochondria, have been decisive to understand the importance of selenium as a micronutrient and its risk–benefit relationship as an antioxidant. Toxification processes have been linked to TrxR inhibition at the active site Sec by xenobiotics such as heavy metals.
The importance of the thioredoxin system extends far beyond the direct action of Trx, TrxR and NADPH as antioxidants. There are crucial interactions of these elements that become determinant for Redox Biology. Examples of those are the complexes between Trx and Apoptosis Signaling Kinase 1 (ASK-1) or Thioredoxin interacting protein (TxniP); oxidation of Trx, as a result of oxidative stress, releases ASK-1 and triggers an apoptotic cascade.
The thioredoxin system is of outmost importance for protein repair and folding, oxidative stress defense, redox signaling, DNA replication and repair, transcription; glucose metabolism, cell cycle arrest and apoptosis regulation. Dysregulation and disrepair of the thioredoxin system has been related to pathological processes such as inflammation, cancer, neurodegenerative and cardiovascular diseases, and diabetes, among others.
Review papers, research papers and short communications are very welcome in the following topics:
- Transcription factors regulating the thioredoxin system expression;
- Homeostasis and Redox systems cooperation;
- Crosstalk between the thioredoxin and the glutathione/glutaredoxin systems;
- Nutrition and the activity of the thioredoxin system;
- Thioredoxin system in health promotion;
- Molecular mechanisms of toxicity involving the thioredoxin system;
- Thioredoxin system and neurodegenerative diseases;
- Thioredoxin system in cancer and cancer therapy;
- Thioredoxin system and fertility outcome;
- Thioredoxin system and disease evolution;
- Thioredoxin system failure and cell death.
- Other related to the subject of the Special Issue can also be proposed by authors to editors.
*Dedicated to our mentor Arne Holmgren, a full-life enthusiastic researcher that always embraced new ideas and will be forever a pioneer on the importance of the thioredoxin system in health and disease, and also to his mentor Peter Reichard who significantly contributed for the discovery thioredoxin and ribonucleotide reductase 60 years ago.
Dr. Cristina M. L. Carvalho
Dr. Vasco Branco
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- thioredoxin system
- thioredoxin reductase
- redox regulation
- redox biology