Special Issue "Modulation of Reactive Oxygen Species in Health and Disease"

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 31 August 2019

Special Issue Editor

Guest Editor
Prof. Solomon Habtemariam

University of Greenwich, Herbal Analysis Services UK, Greenwich, United Kingdom
Website | E-Mail
Interests: Natural products chemistry; pharmacology; drug discovery; pharmacognosy.

Special Issue Information

Dear Colleagues,

Reactive oxygen species (ROS) include radical (e.g., superoxide anion and hydroxyl radical) and non-radical (e.g., hydrogen peroxide and hypochlorous acid) oxygen-derived species that regulate numerous physiological processes. Generated by various cellular mechanisms including the mitochondrial electron transport system and enzymes (e.g., NADPH oxidases and xanthine oxidase), ROS play vital roles in signal transduction mechanisms and in the regulation of cellular processes, ranging from cell viability/proliferation to cell death. Not surprisingly, high levels of ROS in biological systems, resulting from either their excessive production and/or a weak antioxidant defences, could lead to the development of pathological conditions, such as diabetes, obesity, and chronic inflammatory, cardiovascular and neurodegenerative diseases. While lower, but sustained, levels of ROS may promote carcinogenesis, for example, excessive levels could make tumour cells susceptible (e.g., to chemotherapeutic agents) to cell death. Hence, there is a growing awareness that ROS modulation through various pharmacological and other approaches could be employed to alter normal cellular physiology and/or pathologies. This Special Issue is dedicated to providing more insight into recent developments in the field. We welcome original and review article contributions on mechanisms of ROS modulation in health and disease. Novel therapeutic intervention approaches targeting ROS formation or elimination are also welcome.

Prof. Solomon Habtemariam
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Reactive oxygen species
  • Hydroxyl radical
  • Hydrogen peroxide
  • Free radicals
  • Antioxidants

Published Papers (1 paper)

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Open AccessArticle Expression of Antioxidant Enzymes in Patients with Uterine Polyp, Myoma, Hyperplasia, and Adenocarcinoma
Antioxidants 2019, 8(4), 97; https://doi.org/10.3390/antiox8040097
Received: 1 April 2019 / Accepted: 4 April 2019 / Published: 11 April 2019
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We previously found that compared to patients with benign uterine diseases (polyps, myomas), patients with premalignant (hyperplasia simplex and complex) and malignant (adenocarcinoma) lesions had enhanced lipid peroxidation and altered uterine antioxidant enzyme (AOE) activities. To further elucidate the mechanism of the observed [...] Read more.
We previously found that compared to patients with benign uterine diseases (polyps, myomas), patients with premalignant (hyperplasia simplex and complex) and malignant (adenocarcinoma) lesions had enhanced lipid peroxidation and altered uterine antioxidant enzyme (AOE) activities. To further elucidate the mechanism of the observed changes, we examined protein and mRNA levels of copper-zinc superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), and transcription factor Nrf2. We also examined correlations of AOE expression with AOE activity, lipid hydroperoxides (LOOH) level, and level of Nrf2. Our results showed decreased CuZnSOD, CAT, and Nrf2 levels, and increased GPx and GR levels in hyperplasias, while in patients with adenocarcinoma, the level of CAT was decreased and GR was increased, compared to benign groups. Similar changes in mRNA levels were also detected, indicating predominantly translational control of the AOE expression. The positive correlation of enzyme expression/activity was recorded for CuZnSOD, GPx, and GR, but only among groups with benign diseases. Only GR and GPx expressions were positively correlated with LOOH. Nrf2 protein was positively correlated with mRNA levels of CuZnSOD and GR. Observed results indicate involvement of diverse redox mechanisms in etiopathogenesis of different gynecological diseases, and may improve redox-based approaches in current clinical practice. Full article
(This article belongs to the Special Issue Modulation of Reactive Oxygen Species in Health and Disease)

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