Special Issue "Modulation of Reactive Oxygen Species in Health and Disease"
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (31 August 2019).
Interests: natural products chemistry; pharmacology; drug discovery; pharmacognosy
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Reactive oxygen species (ROS) include radical (e.g., superoxide anion and hydroxyl radical) and non-radical (e.g., hydrogen peroxide and hypochlorous acid) oxygen-derived species that regulate numerous physiological processes. Generated by various cellular mechanisms including the mitochondrial electron transport system and enzymes (e.g., NADPH oxidases and xanthine oxidase), ROS play vital roles in signal transduction mechanisms and in the regulation of cellular processes, ranging from cell viability/proliferation to cell death. Not surprisingly, high levels of ROS in biological systems, resulting from either their excessive production and/or a weak antioxidant defences, could lead to the development of pathological conditions, such as diabetes, obesity, and chronic inflammatory, cardiovascular and neurodegenerative diseases. While lower, but sustained, levels of ROS may promote carcinogenesis, for example, excessive levels could make tumour cells susceptible (e.g., to chemotherapeutic agents) to cell death. Hence, there is a growing awareness that ROS modulation through various pharmacological and other approaches could be employed to alter normal cellular physiology and/or pathologies. This Special Issue is dedicated to providing more insight into recent developments in the field. We welcome original and review article contributions on mechanisms of ROS modulation in health and disease. Novel therapeutic intervention approaches targeting ROS formation or elimination are also welcome.
Prof. Solomon Habtemariam
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Reactive oxygen species
- Hydroxyl radical
- Hydrogen peroxide
- Free radicals