10th Anniversary of Antioxidants—Aberrant and Signaling Oxidation of Biomolecules
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Aberrant Oxidation of Biomolecules".
Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 84758
Special Issue Editors
Interests: reactive carbonyls species; advanced glycation end products (AGEs); advanced lipoxidation end products (ALEs); sequestering agents; protein adducts
Special Issues, Collections and Topics in MDPI journals
Interests: liquid chromatography; reactive carbonyl species; spectrometry
Special Issues, Collections and Topics in MDPI journals
Interests: medicinal chemistry; extract
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Biomolecule oxidation involves covalent modifications and occurs both by direct and indirect reaction mechanisms; the direct oxidation is mediated by reactive oxygen species (ROS), the indirect by secondary by-products of oxidative stress, such as lipid-peroxidation break-down products, which covalently adduct the biomolecules.
In vitro and in vivo evidence indicates that biomolecule oxidation is involved in the onset and propagation of several diseases, including cardiovascular and neurological disorders. The damaging effect can be mediated by several mechanisms, including a direct dysregulating effect of the target biomolecule, oligomerization, and epitope formation.
Most recently, it has been found that besides inducing a damaging effect, protein oxidation, in some circumstances, can exert a beneficial effect by stimulating the Nrf2-antioxidant response element signaling pathway; Nrf2 activation controls the expression of genes whose protein products enhance cellular antioxidant capacity and are involved in the detoxication and elimination of reactive oxidants and electrophilic agents.
Based on the above-mentioned premises, the aim of the Special Issue is to collect research and review papers focusing on the damaging and signaling processes induced by oxidized proteins. Papers on the following topics, among others, are welcome: methodological papers on cutting edge analytical approaches for the identification, characterization, and quantification of oxidized biomolecules in different biological samples, including plant, animal and human specimens; OMICs approaches (genomic, proteomic, metabolomic, and lipidomic) to investigate the effect of oxidized biomolecules on cellular pathways; in vitro and in vivo studies on cell signaling evoked by oxidized biomolecules; cellular mechanisms for degradation and removal of oxidized proteins and their regulation; and oxidized biomolecules as drug target and medicinal chemistry approaches for their regulation.
Prof. Dr. Giancarlo Aldini
Dr. Alessandra Altomare
Dr. Giovanna Baron
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.