Biological Activities of Antioxidant Selenoproteins

Dear Colleagues,

Selenoproteins are key determinants of redox balance and antioxidant defense across biological systems. Their activities are essential in mammalian and animal physiology, where they contribute to the protection against oxidative stress, modulation of immune and inflammatory pathways, regulation of energy metabolism, and maintenance of tissue homeostasis. Despite extensive advances, many aspects of their mechanisms of action and broader biological significance remain to be clarified.

This Special Issue aims to highlight recent progress in understanding the antioxidant properties and biological activities of selenoproteins. We are particularly interested in contributions that expand knowledge beyond classical mammalian or animal models, exploring the influence of selenoproteins on microbial systems, including commensal and pathogenic bacteria. Emerging evidence suggests that selenoproteins may affect bacterial growth, oxidative stress resistance, and metabolic activity, thereby shaping the composition and functionality of the microbiota. Such cross-domain interactions may ultimately influence host physiology, opening new perspectives for nutritional, biomedical, and therapeutic applications. By bridging animal and microbial biology, this Special Issue seeks to advance the field of redox research and to emphasize the translational potential of antioxidant selenoproteins in health and disease.

Dr. Raquel Martin-Venegas
Guest Editor

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