Special Issue "Nutrigenomics and Antioxidant Components of Diet"

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".

Deadline for manuscript submissions: 31 December 2020.

Special Issue Editors

Prof. Dr. Rosita Gabbianelli
Website SciProfiles
Guest Editor
School of Pharmacy, University of Camerino, Camerino (MC), Italy
Interests: epigenetics and neurodegeneration; nutrigenomics; xenobiotics and redox system
Special Issues and Collections in MDPI journals
Dr. Laura Bordoni

Guest Editor
School of Pharmacy, University of Camerino, Camerino (MC), Italy
Interests: nutrigenomics; epigenetics and environment

Special Issue Information

Dear Colleagues,

Nutrigenomics aims to evaluate the impact of dietary components on gene expression; in particular, diet is rich in functional groups that, interacting with DNA and histones, can modulate gene expression directly or through chromatin remodeling. Moreover, diet represents an important source of compounds necessary for healthy gut microbiota. Indeed, gut bacteria can produce short-chain fatty acids from fibers contained in vegetables, fruits, and whole grains, thanks to their ability to digest the β-1,4 glycosidic bond, distinctive of the fiber macromolecule.

One of the key points to promote proper nutrigenomic responses is to define adequate food intake and the proportion of macro- and micro-nutrients in accordance with the cultural dietary habits of different populations. Efforts should be addressed to promote education, in particular, to attract the interest of young generations, on the key role of early-life nutrition for the programming of adult health, and to instruct them on how to maintain health across life by a sustainable diet. Taking into account the impact of nutrigenomic research on population health, this Special Issue will publish original research papers, reviews, systematic reviews, and meta-analyses that will contribute to identify and characterize food rich in antioxidants as well as other food components useful to address proper nutrigenomics responses in our body, in order to promote health and appropriate dietary choices consistent with sustainable development. This Special Issue particularly welcomes articles from participants at the 4th European summer school on Nutrigenomics that will take place on June, 22–26, 2020, in Jesi (AN), Italy. This collection will provide further in-depth insight into a range of work and ideas discussed at the event, and also will present recent progress in these areas for researchers beyond the event. The acceptance of an abstract for presentation at the Summer School does not necessarily guarantee the acceptance for publication in the Special Issue, as each article will undergo a peer-reviewed process as established by the usual high standards and guidelines of the journal. Further information can be found at http://d7.unicam.it/nutrigenomics

Prof. Rosita Gabbianelli
Dr. Laura Bordoni
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Nutrigenomics
  • Food antioxidants
  • Diet
  • Food pesticides
  • Gut microbiota
  • Sustainable development

Published Papers (1 paper)

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Open AccessReview
Hesperidin and SARS-CoV-2: New Light on the Healthy Function of Citrus Fruits
Antioxidants 2020, 9(8), 742; https://doi.org/10.3390/antiox9080742 - 13 Aug 2020
Among the many approaches to Coronavirus disease 2019 (COVID-19) prevention, the possible role of nutrition has so far been rather underestimated. Foods are very rich in substances, with a potential beneficial effect on health, and some of these could have an antiviral action [...] Read more.
Among the many approaches to Coronavirus disease 2019 (COVID-19) prevention, the possible role of nutrition has so far been rather underestimated. Foods are very rich in substances, with a potential beneficial effect on health, and some of these could have an antiviral action or be important in modulating the immune system and in defending cells from the oxidative stress associated with infection. This short review draws the attention on some components of citrus fruits, and especially of the orange (Citrus sinensis), well known for its vitamin and flavonoid content. Among the flavonoids, hesperidin has recently attracted the attention of researchers, because it binds to the key proteins of the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several computational methods, independently applied by different researchers, showed that hesperidin has a low binding energy, both with the coronavirus “spike” protein, and with the main protease that transforms the early proteins of the virus (pp1a and ppa1b) into the complex responsible for viral replication. The binding energy of hesperidin to these important components is lower than that of lopinavir, ritonavir, and indinavir, suggesting that it could perform an effective antiviral action. Furthermore, both hesperidin and ascorbic acid counteract the cell damaging effects of the oxygen free radicals triggered by virus infection and inflammation. There is discussion about the preventive efficacy of vitamin C, at the dose achievable by the diet, but recent reviews suggest that this substance can be useful in the case of strong immune system burden caused by viral disease. Computational methods and laboratory studies support the need to undertake apposite preclinical, epidemiological, and experimental studies on the potential benefits of citrus fruit components for the prevention of infectious diseases, including COVID-19. Full article
(This article belongs to the Special Issue Nutrigenomics and Antioxidant Components of Diet)
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