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Article

Extra Virgin Olive Oil Extracts Modulate the Inflammatory Ability of Murine Dendritic Cells Based on Their Polyphenols Pattern: Correlation between Chemical Composition and Biological Function

1
Department of Pharmacy-Drug Science, University of Bari Aldo Moro, 70126 Bari, Italy
2
National Institute of Gastroenterology “S. de Bellis”, Research Hospital, 70013 Castellana Grotte, Italy
3
Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy
4
Pediatric Unit, Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, 70124 Bari, Italy
5
Department of Interdisciplinary Medicine, University of Bari Aldo Moro, 70124 Bari, Italy
*
Authors to whom correspondence should be addressed.
The two authors have equally contributed.
Academic Editors: Rosita Gabbianelli and Laura Bordoni
Antioxidants 2021, 10(7), 1016; https://doi.org/10.3390/antiox10071016
Received: 13 May 2021 / Revised: 11 June 2021 / Accepted: 16 June 2021 / Published: 24 June 2021
(This article belongs to the Special Issue Nutrigenomics and Antioxidant Components of Diet)
Extra virgin olive oil (EVOO) represents one of the most important health-promoting foods whose antioxidant and anti-inflammatory activities are mainly associated to its polyphenols content. To date, studies exploring the effect of EVOO polyphenols on dendritic cells (DCs), acting as a crosstalk between the innate and the adaptive immune response, are scanty. Therefore, we studied the ability of three EVOO extracts (cv. Coratina, Cima di Mola/Coratina, and Casaliva), characterized by different polyphenols amount, to regulate DCs maturation in resting conditions or after an inflammatory stimulus. Cima di Mola/Coratina and Casaliva extracts were demonstrated to be the most effective in modulating DCs toward an anti-inflammatory profile by reduction of TNF and IL-6 secretion and CD86 expression, along with a down-modulation of Il-1β and iNOS expression. From factorial analysis results, 9 polyphenols were tentatively established to play a synergistic role in modulating DCs inflammatory ability, thus reducing the risk of chronic inflammation. View Full-Text
Keywords: extra virgin olive oil; polyphenols; bone marrow-derived dendritic cells; anti-inflammatory properties; HPLC-UV-MS/MS; factor analysis extra virgin olive oil; polyphenols; bone marrow-derived dendritic cells; anti-inflammatory properties; HPLC-UV-MS/MS; factor analysis
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MDPI and ACS Style

De Santis, S.; Liso, M.; Verna, G.; Curci, F.; Milani, G.; Faienza, M.F.; Franchini, C.; Moschetta, A.; Chieppa, M.; Clodoveo, M.L.; Crupi, P.; Corbo, F. Extra Virgin Olive Oil Extracts Modulate the Inflammatory Ability of Murine Dendritic Cells Based on Their Polyphenols Pattern: Correlation between Chemical Composition and Biological Function. Antioxidants 2021, 10, 1016. https://doi.org/10.3390/antiox10071016

AMA Style

De Santis S, Liso M, Verna G, Curci F, Milani G, Faienza MF, Franchini C, Moschetta A, Chieppa M, Clodoveo ML, Crupi P, Corbo F. Extra Virgin Olive Oil Extracts Modulate the Inflammatory Ability of Murine Dendritic Cells Based on Their Polyphenols Pattern: Correlation between Chemical Composition and Biological Function. Antioxidants. 2021; 10(7):1016. https://doi.org/10.3390/antiox10071016

Chicago/Turabian Style

De Santis, Stefania, Marina Liso, Giulio Verna, Francesca Curci, Gualtiero Milani, Maria F. Faienza, Carlo Franchini, Antonio Moschetta, Marcello Chieppa, Maria L. Clodoveo, Pasquale Crupi, and Filomena Corbo. 2021. "Extra Virgin Olive Oil Extracts Modulate the Inflammatory Ability of Murine Dendritic Cells Based on Their Polyphenols Pattern: Correlation between Chemical Composition and Biological Function" Antioxidants 10, no. 7: 1016. https://doi.org/10.3390/antiox10071016

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