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Review

The Effect of Antioxidant and Anti-Inflammatory Capacity of Diet on Psoriasis and Psoriatic Arthritis Phenotype: Nutrition as Therapeutic Tool?

1
Rheumatology and Clinical Immunology Unit, Fourth Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece
2
Second Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece
3
Second Cardiology Department, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, Greece
4
Department of Cardiology, Heart Failure and Preventive Cardiology Section, Ygeia Hospital, 12462 Athens, Greece
5
Independent Researcher, General Physician, 16451 Athens, Greece
6
Second Department of Dermatology and Venereology, University of Athens Medical School, 12462 Athens, Greece
*
Author to whom correspondence should be addressed.
Academic Editor: Rosita Gabbianelli
Antioxidants 2021, 10(2), 157; https://doi.org/10.3390/antiox10020157
Received: 1 January 2021 / Revised: 18 January 2021 / Accepted: 19 January 2021 / Published: 22 January 2021
(This article belongs to the Special Issue Nutrigenomics and Antioxidant Components of Diet)
Chronic inflammation and increased oxidative stress are contributing factors to many non-communicable diseases. A growing body of evidence indicates that dietary nutrients can activate the immune system and may lead to the overproduction of pro-inflammatory cytokines. Fatty acids as macronutrients are key players for immunomodulation, with n-3 polyunsaturated fatty acids having the most beneficial effect, while polyphenols and carotenoids seem to be the most promising antioxidants. Psoriasis is a chronic, immune-mediated inflammatory disease with multifactorial etiology. Obesity is a major risk factor for psoriasis, which leads to worse clinical outcomes. Weight loss interventions and, generally, dietary regimens such as gluten-free and Mediterranean diet or supplement use may potentially improve psoriasis’ natural course and response to therapy. However, data about more sophisticated nutritional patterns, such as ketogenic, very low-carb or specific macro- and micro-nutrient substitution, are scarce. This review aims to present the effect of strictly structured dietary nutrients, that are known to affect glucose/lipid metabolism and insulin responses, on chronic inflammation and immunity, and to discuss the utility of nutritional regimens as possible therapeutic tools for psoriasis and psoriatic arthritis. View Full-Text
Keywords: inflammation; immunity; nutrients; antioxidants; diet; obesity; psoriasis; arthritis; fatty acids inflammation; immunity; nutrients; antioxidants; diet; obesity; psoriasis; arthritis; fatty acids
MDPI and ACS Style

Katsimbri, P.; Korakas, E.; Kountouri, A.; Ikonomidis, I.; Tsougos, E.; Vlachos, D.; Papadavid, E.; Raptis, A.; Lambadiari, V. The Effect of Antioxidant and Anti-Inflammatory Capacity of Diet on Psoriasis and Psoriatic Arthritis Phenotype: Nutrition as Therapeutic Tool? Antioxidants 2021, 10, 157. https://doi.org/10.3390/antiox10020157

AMA Style

Katsimbri P, Korakas E, Kountouri A, Ikonomidis I, Tsougos E, Vlachos D, Papadavid E, Raptis A, Lambadiari V. The Effect of Antioxidant and Anti-Inflammatory Capacity of Diet on Psoriasis and Psoriatic Arthritis Phenotype: Nutrition as Therapeutic Tool? Antioxidants. 2021; 10(2):157. https://doi.org/10.3390/antiox10020157

Chicago/Turabian Style

Katsimbri, Pelagia, Emmanouil Korakas, Aikaterini Kountouri, Ignatios Ikonomidis, Elias Tsougos, Dionysios Vlachos, Evangelia Papadavid, Athanasios Raptis, and Vaia Lambadiari. 2021. "The Effect of Antioxidant and Anti-Inflammatory Capacity of Diet on Psoriasis and Psoriatic Arthritis Phenotype: Nutrition as Therapeutic Tool?" Antioxidants 10, no. 2: 157. https://doi.org/10.3390/antiox10020157

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