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Antioxidants 2018, 7(10), 128; https://doi.org/10.3390/antiox7100128

The Role of Methionine Sulfoxide Reductases in Oxidative Stress Tolerance and Virulence of Staphylococcus aureus and Other Bacteria

1
Department of Microbiology and Immunology, A.T. Still University of Health Sciences, Kirksville, MO 63501, USA
2
Mayo Clinic, Rochester, MN 53905, USA
*
Author to whom correspondence should be addressed.
Received: 31 August 2018 / Revised: 19 September 2018 / Accepted: 26 September 2018 / Published: 28 September 2018
(This article belongs to the Special Issue Methionine Sulfoxide Reductases and Oxidative Damage)
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Abstract

Methionine sulfoxide reductases (MSRA1 and MSRB) are proteins overproduced in Staphylococcus aureus during exposure with cell wall-active antibiotics. Later studies identified the presence of two additional MSRA proteins (MSRA2 and MSRA3) in S. aureus. These MSR proteins have been characterized in many other bacteria as well. This review provides the current knowledge about the conditions and regulatory network that mimic the expression of these MSR encoding genes and their role in defense from oxidative stress and virulence. View Full-Text
Keywords: MSRA; MSRB; oxidative stress; virulence MSRA; MSRB; oxidative stress; virulence
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Singh, V.K.; Singh, K.; Baum, K. The Role of Methionine Sulfoxide Reductases in Oxidative Stress Tolerance and Virulence of Staphylococcus aureus and Other Bacteria. Antioxidants 2018, 7, 128.

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