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Antioxidants 2018, 7(9), 122; https://doi.org/10.3390/antiox7090122

The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases

Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS 66045, USA
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Received: 25 July 2018 / Revised: 15 August 2018 / Accepted: 16 September 2018 / Published: 18 September 2018
(This article belongs to the Special Issue Methionine Sulfoxide Reductases and Oxidative Damage)
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Abstract

This review article describes and discusses the current knowledge on the general role of the methionine sulfoxide reductase (MSR) system and the particular role of MSR type A (MSRA) in mammals. A powerful tool to investigate the contribution of MSRA to molecular processes within a mammalian system/organism is the MSRA knockout. The deficiency of MSRA in this mouse model provides hints and evidence for this enzyme function in health and disease. Accordingly, the potential involvement of MSRA in the processes leading to neurodegenerative diseases, neurological disorders, cystic fibrosis, cancer, and hearing loss will be deliberated and evaluated. View Full-Text
Keywords: methionine sulfoxide reductase; methionine oxidation; oxidative stress methionine sulfoxide reductase; methionine oxidation; oxidative stress
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Jiang, B.; Moskovitz, J. The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases. Antioxidants 2018, 7, 122.

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