Next Article in Journal
Cell-Type-Specific Modulation of Hydrogen Peroxide Cytotoxicity and 4-Hydroxynonenal Binding to Human Cellular Proteins In Vitro by Antioxidant Aloe vera Extract
Next Article in Special Issue
The Role of Methionine Sulfoxide Reductases in Oxidative Stress Tolerance and Virulence of Staphylococcus aureus and Other Bacteria
Previous Article in Journal
Antioxidative 1,4-Dihydropyridine Derivatives Modulate Oxidative Stress and Growth of Human Osteoblast-Like Cells In Vitro
Previous Article in Special Issue
The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessReview
Antioxidants 2018, 7(10), 124;

Methionine Sulfoxide Reductases of Archaea

Department of Microbiology and Cell Science, University of Florida, Gainesville, FL 32611-0700, USA
Received: 29 August 2018 / Revised: 5 September 2018 / Accepted: 11 September 2018 / Published: 20 September 2018
(This article belongs to the Special Issue Methionine Sulfoxide Reductases and Oxidative Damage)
PDF [1935 KB, uploaded 20 September 2018]


Methionine sulfoxide reductases are found in all domains of life and are important in reversing the oxidative damage of the free and protein forms of methionine, a sulfur containing amino acid particularly sensitive to reactive oxygen species (ROS). Archaea are microbes of a domain of life distinct from bacteria and eukaryotes. Archaea are well known for their ability to withstand harsh environmental conditions that range from habitats of high ROS, such as hypersaline lakes of intense ultraviolet (UV) radiation and desiccation, to hydrothermal vents of low concentrations of dissolved oxygen at high temperature. Recent evidence reveals the methionine sulfoxide reductases of archaea function not only in the reduction of methionine sulfoxide but also in the ubiquitin-like modification of protein targets during oxidative stress, an association that appears evolutionarily conserved in eukaryotes. Here is reviewed methionine sulfoxide reductases and their distribution and function in archaea. View Full-Text
Keywords: archaea; methionine sulfoxide reductase; reactive oxygen species; ubiquitin-like modification; thiol relay systems archaea; methionine sulfoxide reductase; reactive oxygen species; ubiquitin-like modification; thiol relay systems

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Maupin-Furlow, J.A. Methionine Sulfoxide Reductases of Archaea. Antioxidants 2018, 7, 124.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Antioxidants EISSN 2076-3921 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top