Role of Hydrogen Sulfide in Health and Disease

Dear Colleagues,

As Guest Editors, we invite you to contribute to the Special Issue entitled “Role of Hydrogen Sulfide in Health and Disease”. Original research reports and reviews will be published online in Antioxidants.

Hydrogen sulfide (H2S), for a long time recognized as a putrid, toxic gas, is actually considered the third gasotransmitter alongside nitric oxide (NO) and carbon monoxide (CO) in mammalian systems. It is endogenously produced from the amino acid L-cysteine (L-Cys) through the activation of two pyridoxal-5-phosphate-dependent enzymes, i.e., cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) or 3-mercaptopyruvate-sulfurtransferase (3-MST). H2S is a small, reactive signaling molecule that can freely diffuse through membranes participating in the modulation of multiple physiological and pathological processes. The current literature reports conflicting data with respect to its biological effects. In particular, H2S, similarly to NO and CO, exhibits pleiotropic and dose-dependent effects on a variety of physiological pathways. Indeed, it is involved in angiogenesis, neuronal activity, vascular homeostasis, glucose metabolism, energy production, and the inflammatory response. Interestingly, an altered H2S biosynthesis is associated with a number of diseases, including heart failure, hypertension, atherosclerosis, asthma, diabetes, neurodegenerative diseases, autoimmunity, and chronic inflammation.

Due to the ambiguous data reported in the literature and possible undiscovered mechanisms underlying H2S driven effects, there is the need to better understand its role in physiology and diseases.

Thus, we invite investigators to contribute to this Special Issue with original research and review articles. In order to improve the current knowledge, papers describing novel mechanism(s) of action and/or interaction that help to clarify whether H2S is friend or foe for human health will be especially welcome and published online in Antioxidants.

Dr. Emma Mitidieri
Guest Editor

Dr. Vincenzo Brancaleone
Co-Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.