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Antioxidants
Special Issues
Antioxidant Actions of Melatonin
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Antioxidant Actions of Melatonin

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: 31 May 2025 | Viewed by 2294

Special Issue Editor

Dr. Gaia Favero

E-Mail Website
Guest Editor
Division of Anatomy and Physiopathology, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
Interests: aging; human anatomy; morphology; oxidative stress; inflammation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Compelling evidence indicates that various bioactive compounds with antioxidant properties contribute to improvements in quality of life by reducing the risk of cellular injury and thus delaying/preventing the onset of several diseases. Melatonin (N-acetyl-5-methoxytryptamine) is an endogenously produced indoleamine synthesized from the essential amino acid tryptophan. This indoleamine is ubiquitously present in all animals and plants where it exerts a variety of physiological activities. Melatonin is well known as a potent scavenger of reactive oxygen species and also as an indirect antioxidant agent due to its ability to up-regulate antioxidant enzymes and down-regulate pro-oxidant enzymes. Not only melatonin but also several of its precursors and metabolites can detoxify free radicals and their derivatives.

Due to its antioxidant properties, as well as other biological actions, melatonin could be a therapeutic/preventive option for improving several disorders. However, more research is needed to fully understand the potential benefits of melatonin.

In this Special Issue, researchers are invited to shed light on the antioxidant actions of melatonin against different injuries and disorders. This Special Issue welcomes manuscripts that introduce new discoveries and expand current knowledge on the impact of melatonin in antioxidant protection. Submissions of different article types to this Special Issue, especially original research papers, reviews, and mini-reviews, are welcome.

Dr. Gaia Favero
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidant effects
  • human health
  • melatonin
  • oxidative stress

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Published Papers (3 papers)

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Research

25 pages, 4135 KiB  
Article
Melatonin Improves Semen Quality by Modulating Oxidative Stress, Endocrine Hormones, and Tryptophan Metabolism of Hu Rams Under Summer Heat Stress and the Non-Reproductive Season
by Qian-Qiu Liu, Xiong Li, Jia-Hao Li, Yang Zhou, Ming-Kai Lei, Wei-Qi Yin, You-She Ren, Chun-He Yang and Chun-Xiang Zhang
Antioxidants 2025, 14(6), 630; https://doi.org/10.3390/antiox14060630 (registering DOI) - 24 May 2025
Abstract
The concurrent occurrence of summer heat stress and the non-breeding season has significantly impaired the semen quality of rams. Currently, there exists no straightforward and efficient method to address this issue. In this study, we demonstrate that two consecutive administrations of melatonin implants [...] Read more.
The concurrent occurrence of summer heat stress and the non-breeding season has significantly impaired the semen quality of rams. Currently, there exists no straightforward and efficient method to address this issue. In this study, we demonstrate that two consecutive administrations of melatonin implants significantly mitigate the adverse effects of summer heat stress and the non-reproductive season on rams. Our findings indicate that implantation of exogenous melatonin enhances semen quality by improving sperm DNA integrity, mitochondrial integrity, and decreasing the proportion of abnormal sperm, as compared to control rams. This improvement is ascribed to the alleviation of oxidative stress and the optimized regulation of endocrine hormone levels in both serum and seminal plasma. Further exploration of the regulatory mechanism reveals that melatonin can also influence the tryptophan metabolism pathway. Additionally, our study revealed that certain indices and metabolites are strongly correlated with semen quality and can potentially serve as indicators for research aimed at improving semen quality. Notably, this is the first time that differences in tryptophan metabolites between serum and seminal plasma have been elucidated. All the above information suggests that melatonin implantation can protect sperm from heat stress by optimizing the blood and semen microenvironment. Full article
(This article belongs to the Special Issue Antioxidant Actions of Melatonin)
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18 pages, 4412 KiB  
Article
The Protective Effects of Melatonin on Hainan Black Goats Under Heat Stress: Understanding Its Actions and Mechanisms
by Hao Wu, Baochun Qin, Guang Yang, Pengyun Ji, Yu Gao, Lu Zhang, Bingyuan Wang and Guoshi Liu
Antioxidants 2025, 14(1), 44; https://doi.org/10.3390/antiox14010044 - 3 Jan 2025
Viewed by 885
Abstract
As the global climate changes, high temperatures will cause heat stress, which significantly affects the productive efficiency of livestock. Currently, there is a lack of efficient methods to use in targeting this issue. In this study, we report that melatonin supplementation may represent [...] Read more.
As the global climate changes, high temperatures will cause heat stress, which significantly affects the productive efficiency of livestock. Currently, there is a lack of efficient methods to use in targeting this issue. In this study, we report that melatonin supplementation may represent an alternative method to reduce the negative impact of heat stress on livestock, particularly in Hainan black goats. Our results show that melatonin treatment increased the average daily gain of Hainan black goats that were exposed to constantly high temperatures for two months compared to controls. Our mechanistic exploration revealed that melatonin treatment not only reduced the oxidative stress and inflammatory reaction caused by heat stress but also improved goats’ metabolic capacity, promoting their growth and development. More importantly, for the first time, we observed that melatonin treatment modified the abundance of the intestinal microflora, altering the metabolism of the goats, which further improved their tolerance to constant heat stress. Full article
(This article belongs to the Special Issue Antioxidant Actions of Melatonin)
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Graphical abstract

24 pages, 27514 KiB  
Article
Melatonin Ameliorates Organellar Calcium Homeostasis, Improving Endoplasmic Reticulum Stress-Mediated Apoptosis in the Vastus Lateralis Muscle of Both Sexes of Obese Diabetic Rats
by Diego Salagre, Miguel Navarro-Alarcón, Luis Gerardo González, Mohamed A. Elrayess, Marina Villalón-Mir, Rocío Haro-López and Ahmad Agil
Antioxidants 2025, 14(1), 16; https://doi.org/10.3390/antiox14010016 - 26 Dec 2024
Viewed by 961
Abstract
Endoplasmic reticulum (ER) stress is a crucial factor in the progression of obesity-related type 2 diabetes (diabesity), contributing to skeletal muscle (SKM) dysfunction, calcium imbalance, metabolic inflexibility, and muscle atrophy. The ER and mitochondria together regulate intracellular calcium levels, and melatonin, a natural [...] Read more.
Endoplasmic reticulum (ER) stress is a crucial factor in the progression of obesity-related type 2 diabetes (diabesity), contributing to skeletal muscle (SKM) dysfunction, calcium imbalance, metabolic inflexibility, and muscle atrophy. The ER and mitochondria together regulate intracellular calcium levels, and melatonin, a natural compound with antioxidant properties, may alleviate these challenges. Our previous research showed that melatonin raises intracellular calcium and preserves muscle structure by enhancing mitochondrial function in obese diabetic rats. This study further explores melatonin’s potential to reduce ER stress in the vastus lateralis (VL) muscle by modulating the unfolded protein response (UPR) and restoring calcium levels disrupted by diabesity. Five-week-old Zücker diabetic fatty (ZDF) rats and lean littermates of both sexes were divided into control and melatonin-treated groups (10 mg/kg/day for 12 weeks). Flame atomic absorption spectrometry results showed that melatonin restored VL intraorganellar calcium homeostasis, increasing calcium levels in mitochondria and reducing them in the ER by raising the activity and expression of calcium transporters in both sexes of ZDF rats. Melatonin also decreased ER stress markers (GRP78, ATF6, IRE1α, and PERK) and reduced pro-apoptosis markers (Bax, Bak, P-JNK, cleaved caspase 3 and 9) while increasing Bcl2 levels and melatonin receptor 2 (MT2) expression. These findings suggest that melatonin may protect against muscle atrophy in obese and diabetic conditions by mitigating ER stress and calcium imbalance, highlighting its therapeutic potential. Full article
(This article belongs to the Special Issue Antioxidant Actions of Melatonin)
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