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Antioxidants
Special Issues
Effect of Nutritional Antioxidants on Health and Disease—The Advance
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Effect of Nutritional Antioxidants on Health and Disease—The Advance

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (25 October 2023) | Viewed by 7389

Special Issue Editors

Prof. Dr. Hao Wu

E-Mail Website
Guest Editor
Department of Nutrition and Food Hygiene, School of Public Health, Shandong University, Jinan 250012, China
Interests: spatial nutrition; omega-3 PUFAs; diabetes; target delivery
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Jianjun Yang

E-Mail Website
Guest Editor
Department of Nutrition and Food Hygiene, School of Public Health, Ningxia Medical University, Yinchuan 750004, China
Interests: nonalcoholic fatty liver disease; hypertension; functional foods; molecular nutrition
Prof. Dr. Songtao Li

E-Mail Website
Guest Editor
Department of Nutrition and Food Hygiene, School of Public Heatlh, Zhejiang Chinese Medical University, Hangzhou 310053, China
Interests: molecular nutrition; functional foods; nutrients; alcoholic liver diseases; non-alcoholic liver diseases

Special Issue Information

Dear Colleagues,

We are what we eat. Nutrients and bioactive food components compose the structure and determine the function of every single cell in the body, thereby deeply affecting the growth, survival, health, and disease of human beings. Therefore, a good diet is essential for the maintenance of health and prevention of disease. To this end, nutritional research strives to understand three key questions: “what to eat”, “how much to eat”, and “how to eat”. Among these, an appropriate choice of food is the critical first step. An antioxidant refers to a substance that inhibits oxidation, a chemical reaction that can produce free radicals. Nutritional antioxidants—nutrients and bioactive food components with antioxidant activities—have been found to be beneficial under various physiological and pathophysiological conditions. However, the understanding of the effects and molecular actions of nutritional antioxidants on health and disease is still limited. The continuous identification of novel types or functions of nutritional antioxidants should facilitate their future application in human health and disease. In this Special Issue, we invite researchers to share their novel findings in this regard. Both original research and review articles are welcomed. Nutritional antioxidants include, but are not limited to:

  • Nutrients such as proteins (peptides and amino acids), fats (fatty acids), carbohydrates, minerals, and vitamins.
  • Bioactive food components, such as phytochemicals and bioactive substances of animal origin.

Prof. Dr. Hao Wu
Prof. Dr. Jianjun Yang
Prof. Dr. Songtao Li
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidant
  • nutrition
  • nutrients
  • bioactive food component
  • phytochemical

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

17 pages, 3688 KiB  
Article
DHA and EPA Alleviate Epileptic Depression in PTZ-Treated Young Mice Model by Inhibiting Neuroinflammation through Regulating Microglial M2 Polarization and Improving Mitochondrial Metabolism
by Yueqi Yang, Lu Chen, Ning Zhang, Yingcai Zhao, Hongxia Che, Yuming Wang, Tiantian Zhang and Min Wen
Antioxidants 2023, 12(12), 2079; https://doi.org/10.3390/antiox12122079 - 6 Dec 2023
Cited by 4 | Viewed by 2878
Abstract
Depression is the most common complication of childhood epilepsy, leading to a poor prognosis for seizure control and poor quality of life. However, the molecular mechanisms underlying epileptic depression have not been completely elucidated. Increasing evidence suggests that oxidative stress and neuroinflammation are [...] Read more.
Depression is the most common complication of childhood epilepsy, leading to a poor prognosis for seizure control and poor quality of life. However, the molecular mechanisms underlying epileptic depression have not been completely elucidated. Increasing evidence suggests that oxidative stress and neuroinflammation are major contributors to depression. The positive effects of dietary supplementation with docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on depression have been previously reported. However, knowledge regarding the effects of EPA and DHA in managing depressive symptoms in pediatric patients with epilepsy is limited. Therefore, this study aims to investigate the effects of EPA and DHA on epileptic depression in a pentylenetetrazole (PTZ)-treated young mouse model. Three-week-old mice were fed a DHA- or EPA-enriched diet for 21 days and treated with PTZ (35 mg/kg, i.p.) every other day for a total of 10 times. EPA was more effective than DHA at alleviating PTZ-induced depressive symptoms. Pathological results revealed that DHA and EPA significantly improved neuronal degeneration in the hippocampus. Analysis of the mechanism revealed that DHA and EPA mitigated PTZ-induced myelin damage by increasing the protein levels of CNPase, Olig2, and MBP. Furthermore, both DHA and EPA reduced neuroinflammation by promoting microglial M2 polarization and suppressing the LCN2-NLRP3 inflammasome pathway. Notably, EPA polarized microglia towards the M2 phenotype. In addition, DHA and EPA decreased oxidative stress by inhibiting NOX2 and enhancing mitochondrial metabolism through the increased expression of mitochondrial respiratory chain complex I-V proteins. These findings suggest that DHA and EPA can be used as effective interventions to improve depression in children with epilepsy, with EPA being a particularly favorable option. Full article
(This article belongs to the Special Issue Effect of Nutritional Antioxidants on Health and Disease—The Advance)
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17 pages, 4265 KiB  
Article
Milk Fat Globule Membrane Relieves Fatigue via Regulation of Oxidative Stress and Gut Microbiota in BALB/c Mice
by Xiaoxiao Zou, Wallace Yokoyama, Xiaohui Liu, Kai Wang, Hui Hong, Yongkang Luo and Yuqing Tan
Antioxidants 2023, 12(3), 712; https://doi.org/10.3390/antiox12030712 - 13 Mar 2023
Cited by 5 | Viewed by 2883
Abstract
Milk fat globule membranes (MFGMs) are complex structures that incorporate bioactive proteins and lipids to assist in infant development. However, the antifatigue and antioxidant potentials of MFGM have not been investigated. In this study, repeated force swimming measured fatigue in male BALB/c mice [...] Read more.
Milk fat globule membranes (MFGMs) are complex structures that incorporate bioactive proteins and lipids to assist in infant development. However, the antifatigue and antioxidant potentials of MFGM have not been investigated. In this study, repeated force swimming measured fatigue in male BALB/c mice fed MFGM and saline for 18 weeks. The MFGM supplementation increased the time to exhaustion by 42.7% at 6 weeks and 30.6% at 14 weeks (p < 0.05). Fatigue and injury-related biomarkers, including blood glucose, lactic acid, and lactate dehydrogenase, were ameliorated after free swimming (p < 0.05). The activity of antioxidant enzymes in blood serum increased at 18 weeks, while malondialdehyde (MDA) content decreased by 45.0% after the MFGM supplementation (p < 0.05). The Pearson correlation analysis showed a high correlation between fatigue-related indices and antioxidant levels. The increased protein expression of hepatic Nrf2 reduced the protein expression of Caspase-3 in the gastrocnemius muscle (p < 0.05). Moreover, the MFGM supplementation increased the relative abundance of Bacteroides, Butyricimonas, and Anaerostipes. Our results demonstrate that MFGM may maintain redox homeostasis to relieve fatigue, suggesting the potential application of MFGM as an antifatigue and antioxidant dietary supplement. Full article
(This article belongs to the Special Issue Effect of Nutritional Antioxidants on Health and Disease—The Advance)
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