Regulatory B Cells
A special issue of Antibodies (ISSN 2073-4468).
Deadline for manuscript submissions: closed (30 June 2019) | Viewed by 6354
Special Issue Editor
Interests: regulation of the humoral immune response; the “crosstalk” between receptors expressed on B lymphocytes; B cell signaling; autoimmunity; rheumatoid arthritis; cooperation between regulatory B cells and T cell subsets
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Besides antigen presentation and antibody production, B cells also play an important role in immune regulation by producing both pro-inflammatory (IL-6, TNF) and anti-inflammatory (IL-10, TGFβ) cytokines. A variety of B cell subsets have been identified as regulatory B cells (Bregs) on the basis of their suppressive function, although no specific marker or transcription factor have been identified. Inflammation provoked by microbes or dying cells may induce the development of Bregs. Breg cells can suppress the immune response by blocking antigen presentation by dendritic cells, inhibiting proliferation and cytokine production by helper T cells, while stimulating the differentiation of regulatory T cells (Tregs). Bregs suppress the inflammatory response by multiple mechanisms, including the secretion of IL-10 and TGFβ, direct cell–cell contact, expression of PD-L1 or FasL.
A lot of work has been conducted to identify Bregs, characterize the signals inducing them, and reveal the regulatory mechanisms involved; however, open questions still remain on the origin of Bregs and on the way they are induced and regulated. Breg cells have been extensively studied in autoimmune diseases and allergy, and emerging evidence suggests that Bregs are pivotal in inducing tolerance in kidney transplantation and a play a protective role in neuroinflammation and experimental stroke. However, tumor-induced Breg cells may promote tumor cell growth.
Thus, although Bregs are crucial players in several immune-mediated disorders, and potential Breg-targeted therapies have been suggested, we have much more to learn about immune response regulation by Bregs before developing Breg-based immunotherapies.
We expect contributions to this Special Issue including recent research on the induction and control of Breg cells, cellular interactions and regulatory mechanisms of Bregs, and their potential therapeutic applications.
Prof. Dr. Gabriella Sármay
Guest Editor
Manuscript Submission Information
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Keywords
- B lymphocyte
- Regulatory B cells
- Immunotherapies
- Cellular therapies
- Breg targeting
- Autoimmune diseases
- Inflammation
- Immunoregulation
- Tolerance induction
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