Optimized Antibody Recovery and Purification Methods
A special issue of Antibodies (ISSN 2073-4468).
Deadline for manuscript submissions: closed (31 March 2015) | Viewed by 7326
Special Issue Editor
Interests: recovery and purification of recombinant biomolecules, bioprocessing of microalgae and transgenic plants; process development and economics
Special Issue Information
Dear Colleagues,
Monoclonal antibodies (MAb) are the fastest growing segment of biotherapeutics, and together with the next generation of therapeutic antibodies are expected to reach worldwide revenues of more than $60 billion in 2015. MAb-based biologics developed and marketed in the past 20 years provided opportunities to treat cancer, autoimmune diseases, and several infectious diseases. To encourage biopharmaceutical industry to introduce new bioprocessing technologies and make antibody-based medications more affordable, many governments have developed polices for approval of follow-on biologics (biosimilars). The entrance of biosimilar antibodies on the market, recent success of antibody-drug conjugates, and increased MAb titers are expected to exert further pressure on downstream process capacity and productivity. In the past ten years, manufacturing cost reduction had been achieved by improving MAb titers, using more efficient Protein A resins, streamlining downstream processing by implementing single-use technologies, and achieving a modest increase in productivity. In spite of the development of reportedly disruptive downstream processing technologies that utilize monoliths, microporous hydrogels and polymers, and a combination of various non-chromatographic formats, expensive Protein A–based downstream processing trains still dominate manufacturing of monoclonal antibodies.This Special Issue focuses on purification and recovery of various therapeutic antibody formats (antibody and antibody fragments, minibodies, antibody fusions, antibody-drug conjugates). The emphasis will be given on downstream processing methods that utilize disruptive technologies for recovery and/or purification of antibodies produced in mammalian cell cultures and Escherichia coli as well as less common production platforms such as plants and algae. Antibody recovery from whole cell cultures by precipitation and other non-chromatographic will be featured in this issue. Pretreatment of cell-free extracts for removal of DNA and aggregates that result in increased purification efficiency will also be considered.
Prof. Dr. Zivko Nikolov
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibodies is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- therapeutic antibodies
- antibody fragments
- antibody conjugates
- downstream processing
- purification
- recovery
- antibodies from transgenic plants
- antibodies from transgenic algae
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