Special Issue "From the Southern Hemisphere: Research on Resistance, Antibiotics and Treatments"

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: 28 February 2019

Special Issue Editors

Guest Editor
Dr. Mark Willcox

School of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia
Website | E-Mail
Interests: development of antimicrobial surfaces; new antimicrobials; bacterial resistance mechanisms; new treatments for infections
Guest Editor
Dr. Debarun Dutta

School of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia
Website | E-Mail
Interests: contact lens and anterior ocular surface; tear film and lipid layer; ocular infection; antibiotic resistance; novel antimicrobial agents to counter bacterial resistance

Special Issue Information

Dear Colleagues,

With the rise in antimicrobial resistance worldwide, many of us have been investigating new ways of overcoming this problem and treating disease. These new technologies may take the form of repurposing antimicrobials, combining antimicrobials for synergy, synthesising new antimicrobials, using phages and parasitic bacteria, as well as understanding the spread of resistance. In this issue we want to highlight new research from the Southern Hemisphere in these, and related areas. Studies can be laboratory based, pre-clinical or clinical; human or animal based. Manuscripts are particularly welcomed in the following areas:

  1. New antimicrobials, including antibiotics, disinfectants, metals
  2. Synthesis of antimicrobials
  3. New methods of testing antimicrobial activity
  4. Phages and parasitic bacteria
  5. Synergism between different types of antimicrobials
  6. Design and testing of antimicrobial surfaces
  7. Epidemiology and spread of microbes and resistance traits

Dr. Mark Willcox
Dr. Debarun Dutta
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Antimicrobial activity
  • Antimicrobial testing
  • Surface bound antimicrobials
  • Antimicrobial release
  • Antimicrobial synergy
  • Resistance genes

Published Papers (1 paper)

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Research

Open AccessArticle Study of Disinfectant Resistance Genes in Ocular Isolates of Pseudomonas aeruginosa
Antibiotics 2018, 7(4), 88; https://doi.org/10.3390/antibiotics7040088
Received: 25 September 2018 / Revised: 11 October 2018 / Accepted: 11 October 2018 / Published: 15 October 2018
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Abstract
Background: The prevalence of disinfectant resistance in Pseudomonas aeruginosa is on the rise. P. aeruginosa is the most common bacteria isolated from cases of microbial keratitis. Many multi-purpose contact lens disinfectant solutions are available to decontaminate contact lenses before use and to help
[...] Read more.
Background: The prevalence of disinfectant resistance in Pseudomonas aeruginosa is on the rise. P. aeruginosa is the most common bacteria isolated from cases of microbial keratitis. Many multi-purpose contact lens disinfectant solutions are available to decontaminate contact lenses before use and to help reduce the incidence of infections. However, with increasing disinfectant resistance, the effect of multi-purpose disinfectant solutions may diminish. The goal of this study was to examine genes associated with disinfectant resistance in ocular isolates of P. aeruginosa and understand the strain’s susceptibility to different multipurpose disinfectant solutions. Methods: Seven potential disinfectant resistance genes were used in BLASTn searches against the whole genomes of 13 eye isolates of P. aeruginosa. A microdilution broth method was used to examine susceptibility to four different multipurpose disinfectant solutions. Results: All strains possessed the sugE2, sugE3 and emrE (qacE) genes. The sugE1 and qacEdelta1 genes were present in 6/13 isolates. No strains contained the qacF or qacG genes. All tested disinfectant solutions had the ability to kill all test strains at 100% concentration, with some strains being susceptible at 1:8 dilutions of the disinfecting solutions. However, the presence of disinfectant resistance genes was not associated with susceptibility to multi-purpose disinfectants. Conclusion: All four tested contact lens disinfectant preparations are effective against P. aeruginosa isolates regardless of the presence of disinfectant resistance genes. Full article
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