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Short Cationic Peptidomimetic Antimicrobials

School of Chemistry, University of New South Wales, Sydney, NSW 2052, Australia
School of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia
Author to whom correspondence should be addressed.
Antibiotics 2019, 8(2), 44;
Received: 29 March 2019 / Revised: 15 April 2019 / Accepted: 15 April 2019 / Published: 18 April 2019
The rapid growth of antimicrobial resistance against several frontline antibiotics has encouraged scientists worldwide to develop new alternatives with unique mechanisms of action. Antimicrobial peptides (AMPs) have attracted considerable interest due to their rapid killing and broad-spectrum activity. Peptidomimetics overcome some of the obstacles of AMPs such as high cost of synthesis, short half-life in vivo due to their susceptibility to proteolytic degradation, and issues with toxicity. This review will examine the development of short cationic peptidomimetics as antimicrobials. View Full-Text
Keywords: peptidomimetics; antibacterials; cationic groups peptidomimetics; antibacterials; cationic groups
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MDPI and ACS Style

Kuppusamy, R.; Willcox, M.; Black, D.S.; Kumar, N. Short Cationic Peptidomimetic Antimicrobials. Antibiotics 2019, 8, 44.

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