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Article

Drug Susceptibility Testing and Synergistic Antibacterial Activity of Curcumin with Antibiotics against Enterotoxigenic Escherichia coli

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Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Calle Sierra Mojada 950, Independencia Oriente, Guadalajara 44340, Jalisco, Mexico
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Departamento de Química, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Blvd. Marcelino García Barragán 1421, Guadalajara 44430, Jalisco, Mexico
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Departamento de Microbiología y Patología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Calle Sierra Mojada 950, Independencia Oriente, Guadalajara 44340, Jalisco, Mexico
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Hospital Regional de Alta Especialidad de Oaxaca, Calle Aldama S/N, 71256 San Bartolo Coyotepec, Oax, Mexico
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Author to whom correspondence should be addressed.
Antibiotics 2019, 8(2), 43; https://doi.org/10.3390/antibiotics8020043
Received: 24 March 2019 / Revised: 11 April 2019 / Accepted: 15 April 2019 / Published: 18 April 2019
Aim: This study investigated the susceptibility of Enterotoxigenic Escherichia coli to curcumin, as well as its synergistic effect with 12 antimicrobial drugs. Methods and Results: Our study shows that curcumin did not affect bacterial growth. The antimicrobial susceptibility of curcumin and antibiotic synergy were identified using disc diffusion on Mueller-Hinton agar. The strain of Enterotoxigenic Escherichia coli used was resistant to Ampicillin, Amoxicillin/Clavulanic acid, Ampicillin/Sulbactam, Ciprofloxacin, and Cefazolin. There was synergy between curcumin and the majority of antibiotics tested. Maximum synergy was observed with combinations of 330 µg/mL curcumin and Ceftazidime, followed by Cefotaxime, Amoxicillin/Clavulanic acid, Ampicillin, Aztreonam, Trimethoprim, Ciprofloxacin, Ceftriaxone, Cefazolin, Tetracycline, and Imipenem. Conclusion: Our findings indicated that curcumin might be useful as a combinatorial strategy to combat the antibiotic resistance of Enterotoxigenic Escherichia coli. View Full-Text
Keywords: curcumin; antibacterial; antibiotics; synergism; Escherichia coli curcumin; antibacterial; antibiotics; synergism; Escherichia coli
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MDPI and ACS Style

Itzia Azucena, R.-C.; José Roberto, C.-L.; Martin, Z.-R.; Rafael, C.-Z.; Leonardo, H.-H.; Gabriela, T.-P.; Araceli, C.-R. Drug Susceptibility Testing and Synergistic Antibacterial Activity of Curcumin with Antibiotics against Enterotoxigenic Escherichia coli. Antibiotics 2019, 8, 43. https://doi.org/10.3390/antibiotics8020043

AMA Style

Itzia Azucena R-C, José Roberto C-L, Martin Z-R, Rafael C-Z, Leonardo H-H, Gabriela T-P, Araceli C-R. Drug Susceptibility Testing and Synergistic Antibacterial Activity of Curcumin with Antibiotics against Enterotoxigenic Escherichia coli. Antibiotics. 2019; 8(2):43. https://doi.org/10.3390/antibiotics8020043

Chicago/Turabian Style

Itzia Azucena, Rangel-Castañeda, Cruz-Lozano José Roberto, Zermeño-Ruiz Martin, Cortes-Zarate Rafael, Hernández-Hernández Leonardo, Tapia-Pastrana Gabriela, and Castillo-Romero Araceli. 2019. "Drug Susceptibility Testing and Synergistic Antibacterial Activity of Curcumin with Antibiotics against Enterotoxigenic Escherichia coli" Antibiotics 8, no. 2: 43. https://doi.org/10.3390/antibiotics8020043

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