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Open AccessArticle

Antibacterial Performance of Terpenoids from the Australian Plant Eremophila lucida

Future Industries Institute, University of South Australia, Mawson Lakes 5095, Australia
Wound Management Innovation Cooperative Research Centre, Toowong 4066, Australia
Quality Use of Medicines and Pharmacy Research Centre, School of Pharmacy and Medical Sciences, University of South Australia, Frome Road, Adelaide 5000, Australia
Author to whom correspondence should be addressed.
Antibiotics 2019, 8(2), 63;
Received: 13 March 2019 / Revised: 12 May 2019 / Accepted: 14 May 2019 / Published: 17 May 2019
Plants in the Australian genus Eremophila (Scrophulariaceae) have attracted considerable recent attention for their antimicrobial compounds, which possess a wide range of chemical structures. As they are typically associated with the oily-waxy resin layer covering leaves and green branchlets, and Eremophila lucida is prominent among the species containing a pronounced sticky resin layer, this species was considered of interest for assessing its antibacterial constituents. The n-hexane fraction of the crude acetone extract of the leaves exhibited antibacterial activity against Staphylococcus aureus. Isolation led to the known compounds cembratriene, (3Z, 7E, 11Z)-15-hydroxycembra-3,7,11-trien-19-oic acid (1), the sesquiterpenoid, farnesal (2) and the viscidane diterpenoid, 5α-hydroxyviscida-3,14-dien-20-oic acid (3). The purified compounds were tested for antibacterial activity with 2 and 3 showing moderate antibacterial activity against Gram-positive bacteria. View Full-Text
Keywords: Eremophila; Scrophulariaceae; diterpenoid; sesquiterpenoid; antimicrobial; antibacterial Eremophila; Scrophulariaceae; diterpenoid; sesquiterpenoid; antimicrobial; antibacterial
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Biva, I.J.; Ndi, C.P.; Semple, S.J.; Griesser, H.J. Antibacterial Performance of Terpenoids from the Australian Plant Eremophila lucida. Antibiotics 2019, 8, 63.

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