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Open AccessArticle

Antibacterial Performance of Terpenoids from the Australian Plant Eremophila lucida

1
Future Industries Institute, University of South Australia, Mawson Lakes 5095, Australia
2
Wound Management Innovation Cooperative Research Centre, Toowong 4066, Australia
3
Quality Use of Medicines and Pharmacy Research Centre, School of Pharmacy and Medical Sciences, University of South Australia, Frome Road, Adelaide 5000, Australia
*
Author to whom correspondence should be addressed.
Antibiotics 2019, 8(2), 63; https://doi.org/10.3390/antibiotics8020063
Received: 13 March 2019 / Revised: 12 May 2019 / Accepted: 14 May 2019 / Published: 17 May 2019
Plants in the Australian genus Eremophila (Scrophulariaceae) have attracted considerable recent attention for their antimicrobial compounds, which possess a wide range of chemical structures. As they are typically associated with the oily-waxy resin layer covering leaves and green branchlets, and Eremophila lucida is prominent among the species containing a pronounced sticky resin layer, this species was considered of interest for assessing its antibacterial constituents. The n-hexane fraction of the crude acetone extract of the leaves exhibited antibacterial activity against Staphylococcus aureus. Isolation led to the known compounds cembratriene, (3Z, 7E, 11Z)-15-hydroxycembra-3,7,11-trien-19-oic acid (1), the sesquiterpenoid, farnesal (2) and the viscidane diterpenoid, 5α-hydroxyviscida-3,14-dien-20-oic acid (3). The purified compounds were tested for antibacterial activity with 2 and 3 showing moderate antibacterial activity against Gram-positive bacteria. View Full-Text
Keywords: Eremophila; Scrophulariaceae; diterpenoid; sesquiterpenoid; antimicrobial; antibacterial Eremophila; Scrophulariaceae; diterpenoid; sesquiterpenoid; antimicrobial; antibacterial
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Biva, I.J.; Ndi, C.P.; Semple, S.J.; Griesser, H.J. Antibacterial Performance of Terpenoids from the Australian Plant Eremophila lucida. Antibiotics 2019, 8, 63.

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