The Quest for Novel Antimicrobials: From Chemical Synthesis and Discovery to Mechanisms of Action and Resistance

Dear Colleagues,

The ongoing worldwide viral pandemic that is affecting all of us highlights the problem of microbial resistance to available drugs and the urgent need for the development of novel antibacterial, antifungal and antiviral compounds. The current rush for the development of antivirals and vaccines to control SARS-COV2 points out the need for the research of novel antifungal and antibacterial compounds to cope with established pathogens and emerging multiresistant strains. In recent years, research laboratories and academia have taken the front edge of research on antimicrobials, as the introduction of novel antibiotics into the market has continuously declined.

This Special Issue aims to gather papers describing novel antimicrobial molecules that are active against bacteria, fungi and viruses, originating from chemical synthesis, repositioning of existent drugs, or from natural sources, like plants, herbs and spices extracts. We are also welcoming papers describing the discovery of novel targets and mechanisms of action and resistance, as well as on the use of omics and bioinformatic approaches to advance the field of novel antimicrobials discovery.

Prof. Jorge H. Leitão
Dr. Luis G. Alves
Guest Editors

Manuscript Submission Information

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