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Open AccessEditor’s ChoiceArticle

Key Parameters on the Antibacterial Activity of Silver Camphor Complexes

1
Centro de Química Estrutural and Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
2
IBB-Institute for Bioengineering and Biosciences, Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
*
Authors to whom correspondence should be addressed.
Academic Editor: Carlos M. Franco
Antibiotics 2021, 10(2), 135; https://doi.org/10.3390/antibiotics10020135
Received: 11 January 2021 / Revised: 23 January 2021 / Accepted: 26 January 2021 / Published: 30 January 2021
Nine new complexes with camphor imine or camphor sulfonimine ligands were synthesized and analytically and spectroscopically characterized, aiming to identify the key parameters that drive the antibacterial activity of the complexes with metal cores and imine substituents with distinct electronic and steric characteristics. The antimicrobial activity of all complexes was evaluated by determining their minimum inhibitory concentrations (MIC) against the Gram-negative Escherichia coli ATCC25922, Pseudomonas aeruginosa 477, and Burkholderia contaminans IST408, and the Gram-positive Staphylococcus aureus Newman. Camphor imine complexes based on the hydroxyl silver center ({Ag(OH)}) typically perform better than those based on the nitrate silver center ({Ag(NO3)}), while ligands prone to establish hydrogen bonding facilitate interactions with the bacterial cell surface structures. A different trend is observed for the silver camphor sulfonimine complexes that are almost non-sensitive to the nature of the metal cores {Ag(OH)} or {Ag(NO3)} and display low sensitivity to the Y substituent. The antibacterial activities of the Ag(I) camphor sulfonimine complexes are higher than those of the camphor imine analogues. All the complexes display higher activity towards Gram-negative strains than towards the Gram-positive strain. View Full-Text
Keywords: silver complexes; camphor imine ligands; antibacterial activity; complex design; redox properties silver complexes; camphor imine ligands; antibacterial activity; complex design; redox properties
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MDPI and ACS Style

Costa, J.P.; Sousa, S.A.; Galvão, A.M.; Mata, J.M.; Leitão, J.H.; Carvalho, M.F.N.N. Key Parameters on the Antibacterial Activity of Silver Camphor Complexes. Antibiotics 2021, 10, 135. https://doi.org/10.3390/antibiotics10020135

AMA Style

Costa JP, Sousa SA, Galvão AM, Mata JM, Leitão JH, Carvalho MFNN. Key Parameters on the Antibacterial Activity of Silver Camphor Complexes. Antibiotics. 2021; 10(2):135. https://doi.org/10.3390/antibiotics10020135

Chicago/Turabian Style

Costa, Joana P.; Sousa, Sílvia A.; Galvão, Adelino M.; Mata, J. M.; Leitão, Jorge H.; Carvalho, M. F.N.N. 2021. "Key Parameters on the Antibacterial Activity of Silver Camphor Complexes" Antibiotics 10, no. 2: 135. https://doi.org/10.3390/antibiotics10020135

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