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Animals
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Fatty Liver in Domestic Animals
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Fatty Liver in Domestic Animals

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Physiology".

Deadline for manuscript submissions: closed (1 August 2020) | Viewed by 5124

Special Issue Editor

Dr. Hay Dvir

E-Mail Website
Guest Editor
Department of Ruminant Science, Institute of Animal Science, Volcani Center, ARO, Rishon LeZion 7505101, Israel
Interests: sheep physiology; pregnancy toxemia; liver metabolism; fatty liver disease

Special Issue Information

Dear Colleagues,

Metabolic fatty liver (FL) develops in a variety of species, including birds, ruminants, and cats, due to either an energy excess or deficit. In all species, it is associated with metabolic derangements and decreased health status.

In domestic ruminants, FL is strongly associated with poor reproductive performance and milk yield and may lead to death in severe cases. Therefore, apart from the significant biomedical interest in elucidating the etiology and the pathogenesis of FL, the identification of predisposing factors and biomarkers for the early detection FL in domestic animals may offer a practical means for disease management.

The purpose of this call is to assemble physiological and molecular level studies related to the induction, characterization, and management of FL in domestic animals. Our aim is to gather a comprehensive body of multidisciplinary studies on liver steatosis in various species to enable the synergistic exchange of valuable information to advance the prevention, management, and therapeutic approaches for this prominent metabolic disorder.

We invite authors to submit relevant original research and/or review articles.

Dr. Hay Dvir
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fatty liver
  • hepatic steatosis
  • metabolic disorder
  • domestic animals

Published Papers (1 paper)

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Research

12 pages, 1943 KiB  
Article
Hepatic Inflammatory Response to Exogenous LPS Challenge is Exacerbated in Broilers with Fatty Liver Disease
by Wenqing Mei, Yarong Hao, Huilin Xie, Yingdong Ni and Ruqian Zhao
Animals 2020, 10(3), 514; https://doi.org/10.3390/ani10030514 - 19 Mar 2020
Cited by 9 | Viewed by 4041
Abstract
This study aimed to examine hepatic function and inflammatory response in broilers with fatty livers, following acute lipopolysaccharide (LPS) challenge. One-day-old Lihua yellow broilers were fed a basal diet. Broilers were divided into four groups: control (CON), corticosterone treatment (CORT), LPS treatment (LPS), [...] Read more.
This study aimed to examine hepatic function and inflammatory response in broilers with fatty livers, following acute lipopolysaccharide (LPS) challenge. One-day-old Lihua yellow broilers were fed a basal diet. Broilers were divided into four groups: control (CON), corticosterone treatment (CORT), LPS treatment (LPS), and LPS and CORT treatment (LPS&CORT). Results show that CORT induced an increase in plasma and liver triglycerides (TGs), which were accompanied by severe hepatic steatosis. The LPS group showed hepatocyte necrosis with inflammatory cell infiltration. Total liver damage score in the LPS&CORT group was significantly higher than that in the LPS group (p < 0.05). Activity levels of plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were similar in the CON and CORT groups, but higher in the LPS group. Gene expression upregulation of the proinflammatory cytokines (NF-κB, IL-1β, IL-6, IFN-γ, and iNOS) was also noted in the LPS group (p < 0.05). In particular, LPS injection exacerbated the gene expression of these proinflammatory cytokines, even when accompanied by CORT injections (p < 0.05). In summary, our results indicate that broilers suffering from fatty liver disease are more susceptible to the negative effects of LPS, showing inflammatory response activation and more severe damages to the liver. Full article
(This article belongs to the Special Issue Fatty Liver in Domestic Animals)
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