Mechanisms of Mammalian Oocyte Quality Control, Molecular Regulation and Solutions
A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Reproduction".
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 4852
Special Issue Editors
Interests: oocyte maturation; oocyte quality control; potential solutions for reduced oocyte quality; infertility
Interests: oocyte; meiosis; oocyte maturation; meiotic maturation; female fertility
Interests: oocyte meiosis maturation; cell cycle control of oocytes
Special Issue Information
Dear Colleagues,
High-quality oocytes, a prerequisite for successful fertilization and subsequent embryonic development, are the material basis for the onset of life. Oocyte meiosis involves two unique features compared with somatic cells: homologous chromosome segregation and asymmetric cell division. The molecular regulation of oocyte maturation still requires further exploration.
Recently, the effects of environmental factors, diseases and food safety on oocyte quality and maternal control have been a subject of increasing interest. Environmental exposures to chemical pollutants found in environments including the air, soil, water and biota, diseases such as obesity and diabetes and contaminated foods intake, including the ingestion of mycotoxins, can affect all oocyte maturation quality and reduce fertilization and early embryo development competence. These exposures could disrupt meiosis resumption, cell cycle progression, meiotic spindle organization, chromosome segregation, actin dynamics, organelle function and polar body extrusion. These exposed oocytes show mitochondria dysfunction, DNA damage, oxidative stress, apoptosis/autophagy and a reduced fertilization rate, indicating that the oocyte quality is affected. Although several solutions, such as the use of melatonin and Resveratrol, are proposed to protect the oocytes from toxic exposure through their effects on oxidative stress via antioxidant functions, studies uncovering effective solutions and applications are still needed.
This Special Issue aims to focus on the effects of molecular regulation and toxic exposure on mammalian oocyte maturation. The expanding body of knowledge on the molecular mechanisms underlying oocyte quality control will provide exciting new insights into oocyte maturation and early development.
We look forward to receiving your contributions.
Dr. Yilong Miao
Dr. Mianqun Zhang
Dr. Yajuan Lu
Guest Editors
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Keywords
- oocyte meiotic maturation
- oocyte quality control
- aging cell cycle control of oocytes
- organelle function of oocytes
- potential solutions for reduced oocyte quality
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