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New Insights in Veterinary and Comparative Reproductive Pathology
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New Insights in Veterinary and Comparative Reproductive Pathology

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 6705

Special Issue Editors

Dr. Gabriele Marino

E-Mail Website
Guest Editor
Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy
Interests: transmissible tumours; reproductive pathology; tumour-like lesions
Special Issues, Collections and Topics in MDPI journals
Dr. Alessandra Sfacteria

E-Mail Website
Guest Editor
Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy
Interests: mammary tumours; translational medicine; cytokines
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Reproductive pathology is an interdisciplinary topic of the reproductive sciences. It is devoted to the understanding of the etiopathogenesis, morphology, and management of gynaecological and andrological diseases. The reproductive pathology of males focuses on the study of accessory glands, penis, and testis. The reproductive pathology of females includes the study of cervix, uterine tube, ovary, uterus, vulva, vagina, and mammary gland. Genital organs modify continuously under hormonal control; the evaluation of pathological changes can be very challenging, and implies a deep knowledge of the morphological and physiological changes during the reproductive cycles, such as the transition from puberty to adult age, from anoestrus to oestrus, and the changes of the uterus and mammary gland during pregnancy and puerperium. All kinds of approaches are welcome. Clinicopathological studies include diagnostic procedures and the study of the biological characteristics of the disease. Classical gross and microscopic studies are powerful in helping to understand and classify lesions in a comparative way. Molecular and genetic studies are ancillary investigations on pathologies able to support clinicians and pathologists in classification, staging, and treatment.

We invite original research papers, review articles, as well as short communications concerning infectious, degenerative, and proliferative lesions of the genital tract of wild and domestic animals. Additional topics about neonatal pathologies are welcome.

Dr. Gabriele Marino
Dr. Alessandra Sfacteria
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • reproduction
  • pathology
  • dysfunction
  • tumour
  • diagnostics
  • histology
  • immunohistochemistry
  • genetics

Published Papers (3 papers)

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Research

12 pages, 3324 KiB  
Article
Prenatal Diagnosis of Canine and Feline Twins Using Ultrasound: A Retrospective Study
by Fabiana Pecchia, Stefania Di Giorgio, Alessandra Sfacteria, Salvatore Monti, Cecilia Vullo, Giuseppe Catone and Gabriele Marino
Animals 2023, 13(21), 3309; https://doi.org/10.3390/ani13213309 - 25 Oct 2023
Viewed by 1686
Abstract
Prenatal diagnosis comprises a set of investigations, both instrumental and laboratory-based, which aim to monitor the health of the foetus during pregnancy, from the early stages of embryonic development to the moments preceding delivery. A growing interest is emerging for the preterm ultrasound [...] Read more.
Prenatal diagnosis comprises a set of investigations, both instrumental and laboratory-based, which aim to monitor the health of the foetus during pregnancy, from the early stages of embryonic development to the moments preceding delivery. A growing interest is emerging for the preterm ultrasound morphological screening of embryos and foetuses, aimed at assessing the integrity and viability of the conceptus, as well as the early diagnosis of anomalies which can cause complications. This study is a retrospective study of the ultrasonographic findings of twins in the authors’ clinical activity from 2016 to 2022. Only seven cases of monochorionic twins were recorded, out of the whole number of evaluations performed on 3120 foetuses, with a prevalence of 0.6% and 0.2% in feline and canine foetuses. All the twins had their own amniotic sac and umbilical cord but presented a single placenta and a single allantoic sac. Unfortunately, the three feline cases were not more recognizable at term. In the four canine cases, three were of opposite sex and then necessarily dizygotic. Twins may have an impact on the success of a pregnancy due to the risk of dystocia, as observed in some of the reported cases. Prenatal ultrasound allows early recognition of twins in dogs and cats. Full article
(This article belongs to the Special Issue New Insights in Veterinary and Comparative Reproductive Pathology)
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13 pages, 825 KiB  
Article
Canine Mammary Tumor Histopathological Image Classification via Computer-Aided Pathology: An Available Dataset for Imaging Analysis
by Giovanni P. Burrai, Andrea Gabrieli, Marta Polinas, Claudio Murgia, Maria Paola Becchere, Pierfranco Demontis and Elisabetta Antuofermo
Animals 2023, 13(9), 1563; https://doi.org/10.3390/ani13091563 - 06 May 2023
Cited by 3 | Viewed by 2854
Abstract
Histopathology, the gold-standard technique in classifying canine mammary tumors (CMTs), is a time-consuming process, affected by high inter-observer variability. Digital (DP) and Computer-aided pathology (CAD) are emergent fields that will improve overall classification accuracy. In this study, the ability of the CAD systems [...] Read more.
Histopathology, the gold-standard technique in classifying canine mammary tumors (CMTs), is a time-consuming process, affected by high inter-observer variability. Digital (DP) and Computer-aided pathology (CAD) are emergent fields that will improve overall classification accuracy. In this study, the ability of the CAD systems to distinguish benign from malignant CMTs has been explored on a dataset—namely CMTD—of 1056 hematoxylin and eosin JPEG images from 20 benign and 24 malignant CMTs, with three different CAD systems based on the combination of a convolutional neural network (VGG16, Inception v3, EfficientNet), which acts as a feature extractor, and a classifier (support vector machines (SVM) or stochastic gradient boosting (SGB)), placed on top of the neural net. Based on a human breast cancer dataset (i.e., BreakHis) (accuracy from 0.86 to 0.91), our models were applied to the CMT dataset, showing accuracy from 0.63 to 0.85 across all architectures. The EfficientNet framework coupled with SVM resulted in the best performances with an accuracy from 0.82 to 0.85. The encouraging results obtained by the use of DP and CAD systems in CMTs provide an interesting perspective on the integration of artificial intelligence and machine learning technologies in cancer-related research. Full article
(This article belongs to the Special Issue New Insights in Veterinary and Comparative Reproductive Pathology)
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18 pages, 4935 KiB  
Article
Quantitative Analysis of Inflammatory Uterine Lesions of Pregnant Gilts with Digital Image Analysis Following Experimental PRRSV-1 Infection
by Dávid G. Horváth, Zsolt Abonyi-Tóth, Márton Papp, Attila Marcell Szász, Till Rümenapf, Christian Knecht, Heinrich Kreutzmann, Andrea Ladinig and Gyula Balka
Animals 2023, 13(5), 830; https://doi.org/10.3390/ani13050830 - 24 Feb 2023
Viewed by 1761
Abstract
Reproductive disorders caused by porcine reproductive and respiratory syndrome virus-1 are not yet fully characterized. We report QuPath-based digital image analysis to count inflammatory cells in 141 routinely, and 35 CD163 immunohistochemically stained endometrial slides of vaccinated or unvaccinated pregnant gilts inoculated with [...] Read more.
Reproductive disorders caused by porcine reproductive and respiratory syndrome virus-1 are not yet fully characterized. We report QuPath-based digital image analysis to count inflammatory cells in 141 routinely, and 35 CD163 immunohistochemically stained endometrial slides of vaccinated or unvaccinated pregnant gilts inoculated with a high or low virulent PRRSV-1 strain. To illustrate the superior statistical feasibility of the numerical data determined by digital cell counting, we defined the association between the number of these cells and endometrial, placental, and fetal features. There was strong concordance between the two manual scorers. Distributions of total cell counts and endometrial and placental qPCR results differed significantly between examiner1’s endometritis grades. Total counts’ distribution differed significantly between groups, except for the two unvaccinated. Higher vasculitis scores were associated with higher endometritis scores, and higher total cell counts were expected with high vasculitis/endometritis scores. Cell number thresholds of endometritis grades were determined. A significant correlation between fetal weights and total counts was shown in unvaccinated groups, and a significant positive correlation was found between these counts and endometrial qPCR results. We revealed significant negative correlations between CD163+ counts and qPCR results of the unvaccinated group infected with the highly virulent strain. Digital image analysis was efficiently applied to assess endometrial inflammation objectively. Full article
(This article belongs to the Special Issue New Insights in Veterinary and Comparative Reproductive Pathology)
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