Utilization of Natural Supplements to Enhance the Well-Being of Poultry During Clostridium and Coccidiosis Challenges

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Welfare".

Deadline for manuscript submissions: 20 August 2025 | Viewed by 793

Special Issue Editor


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Guest Editor
Department of Agriculture, School of Agriculture and Applied Sciences, Alcorn State University, 1000 ASU Drive, Lorman, MI 39096-7500, USA
Interests: broilers; feed additives; intestinal health; phytobiotics; poultry nutrition; probiotics and prebiotics

Special Issue Information

Dear Colleagues,

Intensive poultry production often leads to an increase in the spread of diseases that cause the economic loss of products. The poultry sector suffers from severe financial losses attributed to intestinal necrotic enteritis (NE), which is caused by Clostridium perfringens, with the yearly losses estimated to be 6 billion dollars. Clinical coccidiosis and mild coccidial infections predispose birds to NE. Interactions occur between poultry coccidiosis and other diseases, caused by various pathogens or nutritional imbalances. Clostridioses intercurrent with coccidiosis pose an increased health risk to poultry. Gut injury caused by coccidial infection can predispose poultry to clostridial infection and NE. In addition, the leakage of plasma proteins due to coccidiosis can enable the proliferation of C. perfringens, while mucosal damage and parasitic lesions can compromise the integrity of the gut by preventing efficient digestion and allowing the proliferation of pathogens.

Due to the emergence of antimicrobial resistance bacteria, the use of antimicrobial growth-promoting (AGP) antibiotics has been restricted or banned totally in poultry production. Moreover, the increasing invasion of broiler farms by live anticoccidial vaccines has prompted researchers to question whether vaccines might intensify clostridial diseases. Accordingly, it has become crucial to find novel nutritional strategies that diminish infection with C. perfringens, and ultimately control NE in chickens to improve gut health.

This Special Issue welcomes the submission of reviews and original articles whose scope includes, but is not limited to, the following topics:

  • In vivo and in vitro studies on the effect of natural supplements: types, modes of action and impacts on poultry health and production.
  • Natural supplements and their effect on genomics, genetics and metabolomics tools.
  • Natural supplements and the microbiome of the gut of poultry.
  • Natural supplements and their relation to the immune system of poultry.

Prof. Dr. Alaeldein Mahmood Abudabos
Guest Editor

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Keywords

  • probiotics
  • prebiotics
  • phytobiotics
  • organic acids
  • gut health
  • bacterial challenge
  • coccidial challenge
  • performance
  • gene expression
  • immune system and interleukins

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Published Papers (1 paper)

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Research

20 pages, 5431 KiB  
Article
Enhancing Laying Hen Productivity and Health: Influence of Dietary Probiotic Bacillus Strains and Prebiotic Saccharomyces cerevisiae Yeast Cell Wall on Production Performance, Egg Quality, and Inflammatory Responses
by Zafar M. Hakami, Rashed A. Alhotan, Ali R. Al Sulaiman, Riyadh S. Aljumaah, Valentino Palombo, Mariasilvia D’Andrea, Abdulrahman S. Alharthi and Ala E. Abudabos
Animals 2025, 15(10), 1398; https://doi.org/10.3390/ani15101398 - 12 May 2025
Viewed by 549
Abstract
To evaluate the influences of dietary Bacillus-based probiotics and yeast-based prebiotics over 16 weeks, 500 37-week-old Hisex white layers were indiscriminately assigned to five dietary groups: T1, control; T2, control + Bacillus subtilis (1.1 × 108 CFU/kg); T3, control + Bacillus [...] Read more.
To evaluate the influences of dietary Bacillus-based probiotics and yeast-based prebiotics over 16 weeks, 500 37-week-old Hisex white layers were indiscriminately assigned to five dietary groups: T1, control; T2, control + Bacillus subtilis (1.1 × 108 CFU/kg); T3, control + Bacillus subtilis and Bacillus licheniformis (1.3 × 109 CFU/kg); T4, control + Bacillus coagulans (1.0 × 109 CFU/kg); and T5, control + Saccharomyces cerevisiae yeast cell wall (0.25 g/kg). Cumulatively (p < 0.001), T1 showed the highest feed consumption, while T4 and T5 had higher egg production than T1 and T3. T3 yielded the heaviest eggs, whereas T2 produced the lightest. Egg mass was higher in T3, T4, and T5, with all supplemented groups showing improved feed conversion ratios compared to the control. Furthermore, T5 showed a higher wet yolk weight (p < 0.001), while T2 and T5 had a higher dry albumin weight (p < 0.05). Additionally, T3, T4, and T5 reduced serum IL-1β (p < 0.05), IL-6 (p < 0.01), and TNF-α (p < 0.01), alongside elevated IL-10 levels (p < 0.01) relative to the control. Overall, the results suggest that dietary supplementation with multi-strain combinations and yeast-derived prebiotics can enhance both productivity and immune health in laying hens. Full article
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