Antimicrobial Peptides in Animals and Their Application in Veterinary Medicine

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1620

Special Issue Editors


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Guest Editor
Department of Veterinary Sciences, University of Pisa, Pisa, Italy
Interests: antibacterial activity; antibiotic resistance; microbiology; antibacterial properties of natural substances; leptospirosis; salmonellosis; paratuberculosis
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E-Mail Website
Guest Editor
Department of Veterinary Medicine and Animal Production, University of Naples “Federico II”, Via F. Delpino 1, 80137 Naples, Italy
Interests: veterinary bacteriology; bacterial infections in domestic animals; Staphylococcus pseudintermedius infections; antimicrobial resistance; antimicrobial resistance genes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

From the earliest times, man has always had recourse to natural remedies from the plant and animal kingdoms, for both therapeutic and preventive purposes. Among the natural molecules that have most recently come to the fore in light of some of their important properties, including antibacterial ones, there are natural peptides. They belong to a large and extremely varied group of active molecules of the innate immune response, which represent the first line of defense against pathogens in many organisms, such as bacteria, fungi, insects, amphibians, and fish, up to the more evolved mammals, including primates and man himself. Their compositions and physicochemical characteristics allow them to interact selectively with the bacterial membrane, causing the death of microorganisms. In particular, in view of the growing phenomenon of antibiotic resistance, it seems desirable to envisage the increasingly widespread use of these compounds in both medical and veterinary antimicrobial therapy and prophylaxis, as well as in safeguarding the hygienic integrity of many foodstuffs.

The aim of this Special Issue of Animals is to provide a collection of papers exploring the current and potential application of antimicrobial peptides as alternative therapeutic strategies with which to contrast the antibiotic resistance issue. Therefore, research articles and review articles on this interesting and promising topic are welcome.

Dr. Filippo Fratini
Dr. Francesca Paola Nocera
Guest Editors

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Keywords

  • bacteria
  • antibiotic resistance
  • antimicrobial peptides
  • mechanisms of action
  • clinical potential

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Published Papers (1 paper)

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Research

13 pages, 628 KiB  
Article
Evaluation of the Synergistic Antimicrobial Activity of Essential Oils and Cecropin A Natural Peptide on Gram-Negative Bacteria
by Filippo Fratini, Chiara Pecorini, Ilaria Resci, Emma Copelotti, Francesca Paola Nocera, Basma Najar and Simone Mancini
Animals 2025, 15(2), 282; https://doi.org/10.3390/ani15020282 - 20 Jan 2025
Cited by 1 | Viewed by 1180
Abstract
In an era dominated by the phenomenon of antibiotic resistance, it is increasingly important to look for alternatives to synthetic antibiotics. In light of these considerations, the synergistic use of essential oils and Antimicrobial Peptides (AMPs) seems a viable strategy. In this study, [...] Read more.
In an era dominated by the phenomenon of antibiotic resistance, it is increasingly important to look for alternatives to synthetic antibiotics. In light of these considerations, the synergistic use of essential oils and Antimicrobial Peptides (AMPs) seems a viable strategy. In this study, we assessed the Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC) and Fractional Inhibitory Concentration (FIC) of three Essential Oils (EOs): winter savory (Satureja montana), bergamot (Citrus bergamia) and cinnamon (Cinnamomum zeylanicum) and of the insect antimicrobial peptide Cecropin A (CecA), alone and in combination with EOs, against two Gram-negative ATCC bacterial strains: Escherichia coli and Salmonella enterica serovar Typhimurium. The MIC results showed that winter savory EO (SmEO) and cinnamon EO (CzEO) exhibited the strongest antibacterial activity against both bacterial strains, whereas bergamot EO (CbEO) and CecA demonstrated comparatively lower antibacterial efficacy. These results were also confirmed by the MBC values. The FIC Indices (FICI) revealed that the most effective synergies were observed with the combinations SmEO/CzEO and SmEO/CbEO against E. coli, while against S. enterica Typhimurium the best combinations were CbEO/CzEO and SmEO/CzEO. Regarding CecA, although it was not the most efficient agent either individually or in combination, it is noteworthy that, when combined, it exhibited antibacterial activity even at a 1:64 dilution. Full article
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