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  • Article
  • Open Access

Sex Differences in Preoperative Risk Profiles and 1-Year Mortality Following Elective Cardiac Surgery: A Retrospective Single-Centre Cohort Study

  • Caitlin Bozic,
  • Magnus Strypet,
  • Floor J. Mansvelder,
  • Evert K. Jansen,
  • Jennifer S. Breel,
  • Henning Hermanns and
  • Susanne Eberl
J. Clin. Med.2026, 15(1), 59;https://doi.org/10.3390/jcm15010059 
(registering DOI)

21 December 2025

Background: Sex-related differences in outcomes following cardiac surgery are well documented, with females generally experiencing higher postoperative mortality rates than males. However, the underlying factors driving this disparity remain incomple...

  • Article
  • Open Access

Comparison of Different Surgical Techniques for Osia® System Implantation—Experience from Two European Clinical Centers

  • Wojciech Gawęcki,
  • Ann-Kathrin Rauch,
  • Marta Pietraszek,
  • Maria Jaworska and
  • Susan Arndt
J. Clin. Med.2026, 15(1), 57;https://doi.org/10.3390/jcm15010057 
(registering DOI)

21 December 2025

Background/Objectives: This study aimed to compare two surgical techniques for Osia® system implantation performed at two European clinical centers: Poznań (Poland) and Freiburg (Germany). Methods: The study included 83 patients who underwen...

  • Article
  • Open Access

Analysis of Treatment Influence on Kidney Function and Brain Non-Contrast MRI Vascular Manifestations of Systemic ANCA-Associated Vasculitis with Renal Involvement

  • Arkadiusz Lubas,
  • Jacek Staszewski,
  • Ksymena Leśniak,
  • Grzegorz Spłocharski,
  • Arkadiusz Zegadło,
  • Artur Maliborski,
  • Aleksander Dębiec,
  • Julia Bryłowska,
  • Tymoteusz Lubas and
  • Stanisław Niemczyk
J. Clin. Med.2026, 15(1), 58;https://doi.org/10.3390/jcm15010058 
(registering DOI)

21 December 2025

Background: Antineutrophil cytoplasmic antibody-associated systemic vasculitis (AAV) most often involves the kidneys, upper airways and lungs, and peripheral and central nervous systems (PNS, CNS). However, in contrast to PNS, the involvement of the...

  • Article
  • Open Access
J. Clin. Med.2026, 15(1), 56;https://doi.org/10.3390/jcm15010056 
(registering DOI)

21 December 2025

Objectives: The aim of this study was to evaluate the clinical outcomes and surgical techniques of A-stream Glaucoma Shunt (A-stream; MICROT Inc.) implantation. Methods: A retrospective review of 59 eyes from 59 patients who underwent A-stream implan...

  • Article
  • Open Access

Inflammatory Response Indices in Patients with Acute Ischemic Stroke Treated with and Without Reperfusion Therapy

  • Milena Świtońska,
  • Agnieszka Rogalska,
  • Natalia Mysiak,
  • Agata Staniewska,
  • Alicja Szulc,
  • Oliwia Jarosz,
  • Magdalena Konieczna-Brazis,
  • Magdalena Grigorief,
  • Daria Frąckowska and
  • Jacek Budzyński
J. Clin. Med.2026, 15(1), 55;https://doi.org/10.3390/jcm15010055 
(registering DOI)

21 December 2025

Background: Ischemic stroke remains a leading cause of mortality and long-term disability worldwide. Reperfusion therapies, such as intravenous thrombolysis and mechanical thrombectomy, are crucial for restoring cerebral blood flow but may also trigg...

  • Article
  • Open Access

Real-World Safety of Cyproheptadine-Based Appetite Stimulants: An Electronic Health Record-Based Retrospective Cohort Study in Adult Patients

  • Minoh Ko,
  • Kwangsoo Kim,
  • Heeman Jang,
  • Soomin Lee,
  • Bumkyu Shin,
  • Belong Cho,
  • Seungyeon Kim and
  • Ha Young Jang
J. Clin. Med.2026, 15(1), 54;https://doi.org/10.3390/jcm15010054 
(registering DOI)

21 December 2025

Background: Cyproheptadine-based appetite stimulants (CAS) have been safely used in Korea for over 30 years. However, in older adults who are vulnerable to malnutrition, sarcopenia, and fall-related morbidity, safety of CAS in nutrition care remains...

  • Article
  • Open Access

Molecular Characterization of Adult-Type Lower-Grade Glioma (WHO Grade 1–3) with Targeted Next-Generation Sequencing: A Retrospective, Single-Institution Experience

  • Maurizio Pinamonti,
  • Maurizio Polano,
  • Giacomo Cester,
  • Federico Saturno Spurio,
  • Erik Roman-Pognuz,
  • Maja Ukmar,
  • Michele Dal Bo,
  • Fabrizio Zanconati,
  • Leonello Tacconi and
  • Antonio Meola
J. Clin. Med.2026, 15(1), 53;https://doi.org/10.3390/jcm15010053 
(registering DOI)

21 December 2025

Background/Objectives: The 2021 WHO Classification of Central Nervous System (CNS) tumors emphasizes the integration of molecular data with histopathological features. Lower-grade gliomas (LGGs) represent a heterogeneous group of neoplasms with varia...

  • Review
  • Open Access

Subcutaneous Estradiol Pellets as Hormone Therapy in Menopause: Clinical Pharmacology, Patient Selection and Safety Considerations

  • Leonardo Jacobsen,
  • Daniela Maia Fernandes,
  • Maria Luiza Nagel,
  • Eline Lobo de Souza and
  • Diogo Pinto da Costa Viana
J. Clin. Med.2026, 15(1), 48;https://doi.org/10.3390/jcm15010048 
(registering DOI)

21 December 2025

Background: Among hormone therapy options for menopause, subcutaneous estradiol pellets offer sustained hormone release, avoid first-pass hepatic metabolism, and maintain a near-physiological estradiol-to-estrone ratio. Despite clinical use since the...

  • Article
  • Open Access

Synovial Periprosthetic Infection Markers Show High Variability in Different Clinical and Microbiological Settings

  • Joachim Ortmayr,
  • Jennifer Straub,
  • Klemens Vertesich,
  • Irene Katharina Sigmund,
  • Christoph Böhler,
  • Reinhard Windhager and
  • Kevin Staats
J. Clin. Med.2026, 15(1), 52;https://doi.org/10.3390/jcm15010052 
(registering DOI)

21 December 2025

Background/Objectives: Accurately diagnosing a periprosthetic joint infection (PJI) represents a challenging and complex task. Especially in the case of low-grade infections, important diagnostic modalities may be inconclusive and synovial markers su...

  • Feature Paper
  • Review
  • Open Access

Current Perspectives on Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension

  • Hyungdon Kook,
  • Woohyeun Kim,
  • Ran Heo,
  • Kyunam Kim,
  • Seung-Jin Yoo,
  • Hyunsoo Kim,
  • Dong Won Park and
  • Young-Hyo Lim
J. Clin. Med.2026, 15(1), 51;https://doi.org/10.3390/jcm15010051 
(registering DOI)

21 December 2025

Balloon pulmonary angioplasty (BPA) has become an established treatment modality for patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH), particularly in those with distal pulmonary artery lesions or significant comorbiditi...

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J. Clin. Med. - ISSN 2077-0383