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Viruses | Top-Cited Papers from 2025

Viruses | Top-Cited Papers from 2025

30 December 2025


1. “Latin America’s Dengue Outbreak Poses a Global Health Threat”
by Michelle Teixeira de Almeida, Davi Gabriel Salustiano Merighi, Aline Biazola Visnardi, Cauê Augusto Boneto Gonçalves, Vitor Martins de Freitas Amorim, Anielle Salviano de Almeida Ferrari, Anacleto Silva de Souza and Cristiane Rodrigues Guzzo
Viruses 2025, 17(1), 57; https://doi.org/10.3390/v17010057
Available online: https://www.mdpi.com/1999-4915/17/1/57

2. “Self-Amplifying RNA: Advantages and Challenges of a Versatile Platform for Vaccine Development”
by Thomas Vallet and Marco Vignuzzi
Viruses 2025, 17(4), 566; https://doi.org/10.3390/v17040566
Available online: https://www.mdpi.com/1999-4915/17/4/566 

3. “A Comprehensive Review of the Neglected and Emerging Oropouche Virus”
by Fengwei Bai, Prince M. D. Denyoh, Cassandra Urquhart, Sabin Shrestha and Donald A. Yee
Viruses 2025, 17(3), 439; https://doi.org/10.3390/v17030439
Available online: https://www.mdpi.com/1999-4915/17/3/439 

4. “Repurposing Drugs for Synergistic Combination Therapies to Counteract Monkeypox Virus Tecovirimat Resistance”
by Haydar Witwit, Beatrice Cubitt, Roaa Khafaji, Esteban M. Castro, Miguel Goicoechea, Maria M. Lorenzo, Rafael Blasco, Luis Martinez-Sobrido and Juan C. de la Torre
Viruses 2025, 17(1), 92; https://doi.org/10.3390/v17010092
Available online: https://www.mdpi.com/1999-4915/17/1/92

5. “Current Dengue Virus Vaccine Developments and Future Directions”
by Govindaraj Anumanthan, Bikash Sahay and Ayalew Mergia
Viruses 2025, 17(2), 212; https://doi.org/10.3390/v17020212
Available online: https://www.mdpi.com/1999-4915/17/2/212 

6. “Adeno-Associated Virus Vectors: Principles, Practices, and Prospects in Gene Therapy”
by Limor Zwi-Dantsis, Saira Mohamed, Giulia Massaro and Emad Moeendarbary
Viruses 2025, 17(2), 239; https://doi.org/10.3390/v17020239
Available online: https://www.mdpi.com/1999-4915/17/2/239

7. “Long Non-Coding RNA THRIL Promotes Influenza Virus Replication by Inhibiting the Antiviral Innate Immune Response”
by Mengying Chen, Jingyun Hu, Xinni Zhou, Ming Gao, Ning Li, Guihong Yang, Xiaojuan Chi and Song Wang
Viruses 2025, 17(2), 153; https://doi.org/10.3390/v17020153
Available online: https://www.mdpi.com/1999-4915/17/2/153

8. “Colorimetric Reverse Transcription Loop-Mediated Isothermal Amplification with Xylenol Orange Targeting Nucleocapsid Gene for Detection of Feline Coronavirus Infection”
by Kotchaporn Khumtong, Witsanu Rapichai, Wichayet Saejung, Piyamat Khamsingnok, Nianrawan Meecharoen, Siriluk Ratanabunyong, Hieu Van Dong, Supansa Tuanthap, Amonpun Rattanasrisomporn, Kiattawee Choowongkomon et al.
Viruses 2025, 17(3), 418; https://doi.org/10.3390/v17030418
Available online: https://www.mdpi.com/1999-4915/17/3/418

9. “Antagonistic Trends Between Binding Affinity and Drug-Likeness in SARS-CoV-2 Mpro Inhibitors Revealed by Machine Learning”
by Anacleto Silva de Souza, Vitor Martins de Freitas Amorim, Eduardo Pereira Soares, Robson Francisco de Souza and Cristiane Rodrigues Guzzo
Viruses 2025, 17(7), 935; https://doi.org/10.3390/v17070935
Available online: https://www.mdpi.com/1999-4915/17/7/935

10. “Transcriptional Upregulation of HERV-env Genes Under Simulated Microgravity”
by Seyedesomaye Jasemi, Elena Rita Simula, Antonella Pantaleo and Leonardo A. Sechi
Viruses 2025, 17(3), 306; https://doi.org/10.3390/v17030306
Available online: https://www.mdpi.com/1999-4915/17/3/306