Journal of Clinical Medicine | Most Downloaded Papers in 2025

Journal of Clinical Medicine (JCM, ISSN: 2077-0383) is an open access journal, with an Impact Factor of 2.9 (2024) and 5-Year Impact Factor of 3.3 (2024), which continues to contribute to the widespread dissemination of medical research with professionalism and reliability. In the first half of 2025, the papers published by JCM have garnered significant popularity with many readers. Here, we have selected 15 high-impact papers with a high average number of downloads to form the following selected collection of recommendations. These research results cover cardiovascular disease, heart failure, diabetes, spinal trauma, hemodialysis, neurodegenerative diseases, spondyloarthritis, cervical spine disease, cardiorenal syndrome, knee replacement, pancreatic tumors, pituitary tumors, inflammatory bowel disease, cancer, and other fields. We hope this will inspire your own research.

You can find the latest research through this link: https://www.mdpi.com/search?q=&journal=jcm&sort=pubdate&page_count=50.

1. “Now and the Future: Medications Changing the Landscape of Cardiovascular Disease and Heart Failure Management”
by Thomas Oswald, Steven Coombs, Susan Ellery and Alexander Liu
J. Clin. Med. 2025, 14(11), 3948; https://doi.org/10.3390/jcm14113948
Full text available online: https://www.mdpi.com/2077-0383/14/11/3948

2. “The Relationship of the Plasma Glycated CD59 Level with Microvascular Complications in Diabetic Patients and Its Evaluation as a Predictive Marker”
by Ozgur Yilmaz, Osman Erinc, Ayca Gul Gungordu, Mehmet Erdogan, Murvet Algemi and Murat Akarsu
J. Clin. Med. 2025, 14(13), 4588; https://doi.org/10.3390/jcm14134588
Full text available online: https://www.mdpi.com/2077-0383/14/13/4588

3. “Minimally Invasive Lateral Thoracic and Lumbar Interbody Fusion with Expandable Interbody Spacers for Spine Trauma—Indications, Complications and Outcomes”
by Linda Bättig, Gregor Fischer, Benjamin Martens, Anand Veeravagu, Lorenzo Bertulli and Martin N. Stienen
J. Clin. Med. 2025, 14(13), 4557; https://doi.org/10.3390/jcm14134557
Full text available online: https://www.mdpi.com/2077-0383/14/13/4557

4. “Hemodynamic Adaptation and Cardiac Effects of High-Flow Arteriovenous Access in Hemodialysis Patients: A Prospective Study”
by Yaeni Kim, Ji-hye Kim, Juyeon Woo, Oknan Choi, Mina Lee and Sunryoung Choi
J. Clin. Med. 2025, 14(13), 4556; https://doi.org/10.3390/jcm14134556
Full text available online: https://www.mdpi.com/2077-0383/14/13/4556

5. “Visualization of the Glymphatic System Through Brain Magnetic Resonance in Human Subjects with Neurodegenerative Disorders: A Systematic Review and Meta-Analysis”
by Jana Hamzeh, Hayat Harati, Farah Ayoubi, Marie-belle Saab, Lea Saab, Elie Al Ahmar and Elias Estephan
J. Clin. Med. 2025, 14(12), 4387; https://doi.org/10.3390/jcm14124387
Full text available online: https://www.mdpi.com/2077-0383/14/12/4387

6. “Prevalence of Undiagnosed Inflammatory Bowel Disease in Spondyloarthritis Patients”
by Jesús Sanz-Sanz, Ana Gutiérrez-Casbas, Zulema Plaza, Jordi Gratacós, Iago Rodríguez-Lago, Ignacio Marín-Jiménez, Elisa Trujillo-Martín, Eva Pérez-Pampín, Manuel Barreiro-de Acosta, María Vanesa Hernández-Hernández et al.
J. Clin. Med. 2025, 14(13), 4569; https://doi.org/10.3390/jcm14134569
Full text available online: https://www.mdpi.com/2077-0383/14/13/4569

7. “Effects of Pre-Operative HbA1c on Outcomes and the Rate of Clinical Improvement Following Anterior Cervical Discectomy and Fusion”
by Ara Khoylyan, Noah Coleman, Matthew Parry, Alex Tang and Tan Chen
J. Clin. Med. 2025, 14(13), 4589; https://doi.org/10.3390/jcm14134589
Full text available online: https://www.mdpi.com/2077-0383/14/13/4589

8. “A Pragmatic Approach to Acute Cardiorenal Syndrome: Diagnostic Strategies and Targeted Therapies to Overcome Diuretic Resistance”
by Patrick Tran, Laith Khweir, Michael Kuehl, Mithilesh Joshi, Krishna Appunu, Waqar Ayub and Prithwish Banerjee
J. Clin. Med. 2025, 14(9), 2996; https://doi.org/10.3390/jcm14092996
Full text available online: https://www.mdpi.com/2077-0383/14/9/2996

9. “The Temporal–Spatial Parameters of Gait After Total Knee Arthroplasty”
by Karina Szczypiór-Piasecka, Paulina Adamczewska, Łukasz Kołodziej and Paweł Ziętek
J. Clin. Med. 2025, 14(13), 4548; https://doi.org/10.3390/jcm14134548
Full text available online: https://www.mdpi.com/2077-0383/14/13/4548

10. “Clinical Features of Intraductal Papillary Mucinous Neoplasm-Related Pancreatic Carcinomas in Long-Term Surveillance”
by Kyohei Matsuura, Shinsaku Nagamatsu, Shoma Kikukawa, Yuya Nishio, Yusuke Komeda, Yuya Matsuo, Kohei Ohta, Chisa Yamamoto, Ayana Sueki and Kei Moriya
J. Clin. Med. 2025, 14(13), 4585; https://doi.org/10.3390/jcm14134585
Full text available online: https://www.mdpi.com/2077-0383/14/13/4585

11. “Eye Selection Criteria’s Influence in the Value of Pituitary Macroadenoma Management Biomarkers: Preliminary Findings”
by Odelaisys Hernández-Echevarría, Elizabeth Bárbara Cuétara-Lugo, Mario Jesús Pérez-Benítez, Lídice Galán-García, Ibrain Piloto-Diaz and Eduardo Fernández
J. Clin. Med. 2025, 14(13), 4542; https://doi.org/10.3390/jcm14134542
Full text available online: https://www.mdpi.com/2077-0383/14/13/4542

12. “Assessing ChatGPT-v4 for Guideline-Concordant Inflammatory Bowel Disease: Accuracy, Completeness, and Temporal Drift”
by Oguz Ozturk, Mucahit Ergul, Yavuz Cagir, Ali Atay, Kadir Can Acun, Orhan Coskun, Ilyas Tenlik, Muhammed Bahaddin Durak and Ilhami Yuksel
J. Clin. Med. 2025, 14(13), 4599; https://doi.org/10.3390/jcm14134599
Full text available online: https://www.mdpi.com/2077-0383/14/13/4599

13. “Risk Factors and Prevention of Cancer and CVDs: A Chicken and Egg Situation”
by Maurizio Giuseppe Abrignani, Fabiana Lucà, Vincenzo Abrignani, Mariacarmela Nucara, Daniele Grosseto, Chiara Lestuzzi, Marinella Mistrangelo, Bruno Passaretti, Carmelo Massimiliano Rao and Iris Parrini
J. Clin. Med. 2025, 14(9), 3083; https://doi.org/10.3390/jcm14093083
Full text available online: https://www.mdpi.com/2077-0383/14/9/3083

14. “Cardiovascular–Kidney–Metabolic Syndrome: A New Paradigm in Clinical Medicine or Going Back to Basics?”
by Victoria Mutruc, Cristina Bologa, Victorița Șorodoc, Alexandr Ceasovschih, Bianca Codrina Morărașu, Laurențiu Șorodoc, Oana Elena Catar and Cătălina Lionte
J. Clin. Med. 2025, 14(8), 2833; https://doi.org/10.3390/jcm14082833
Full text available online: https://www.mdpi.com/2077-0383/14/8/2833

15. “Endoscopic-Ultrasound-Guided Radiofrequency Ablation for Pancreatic Tumors”
by Chiara Coluccio, Stefania Cappetta, Giovanna Romagnoli, Valentina Di Giorgio, Paolo Giuffrida, Stefano Fabbri, Carlo Fabbri and Cecilia Binda
J. Clin. Med. 2025, 14(2), 495; https://doi.org/10.3390/jcm14020495
Full text available online: https://www.mdpi.com/2077-0383/14/2/495