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Organoids, Volume 5, Issue 1

2026 March - 4 articles

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Articles (4)

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Article

233 Views

17 Pages

A Fully Annotated Hepatoblastoma Tumoroid Biobank Details Treatment-Induced Evolution and Clonal Dynamics in Paediatric Cancer Patients

Gijs J. F. van Son,
Femke C. A. S. Ringnalda,
Markus J. van Roosmalen,
Thomas A. Kluiver,
Quinty Hansen,
Evelien Duiker,
Marius C. van den Heuvel,
Vincent E. de Meijer,
Ruben H. de Kleine and
Hans Clevers
+ 6 authors

Organoids2026, 5(1), 4;https://doi.org/10.3390/organoids5010004

18 January 2026

Hepatoblastoma (HB) is a paediatric liver malignancy arising from hepatic precursor cells, with >90% of cases harbouring a mutation in exon 3 of CTNNB1. We present a fully genetically characterised HB tumour organoid (tumoroid) biobank, which allo...

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Article

174 Views

18 Pages

Synergistic Overexpression of Sox9, TGFβ1, and Col II Induces Functional Chondrogenesis in hUC-MSCs Using a 3D Culture Approach

Shumaila Khalid,
Sobia Ekram,
Faiza Ramzan,
Asmat Salim and
Irfan Khan

Organoids2026, 5(1), 3;https://doi.org/10.3390/organoids5010003

14 January 2026

Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) possess the potential for chondrogenic differentiation, offering a promising alternative source for cartilage regeneration. To address the limited availability and expansion capacity of a...

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Review

667 Views

18 Pages

Decellularized Extracellular Matrix for Organoids Development and 3D Bioprinting

Elena Gkantzou,
Alexandro Rodríguez-Rojas,
Aleksandra Chmielewska,
Barbara Pratscher,
Surina Surina,
Patricia Freund and
Iwan A. Burgener

Organoids2026, 5(1), 2;https://doi.org/10.3390/organoids5010002

8 January 2026

Organoids are three-dimensional multicellular structures that mimic key aspects of native tissues consisting ideal tools to study organ development and pathophysiology when incorporated in customized bioscaffolds. In vivo, the extracellular matrix (E...

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Article

432 Views

19 Pages

Permeability of the Blood–Brain Barrier (BBB) to Nanoparticles, Bacteria and Phages Studied in BBB Organoids Under Normoxic and Hypoxic Conditions In Vitro

Kathrin Kostka-Wirtz,
Nataniel Białas,
Ivanna Kostina and
Matthias Epple

Organoids2026, 5(1), 1;https://doi.org/10.3390/organoids5010001

2 January 2026

Organoids consisting of primary human cells, i.e., astrocytes, pericytes, and endothelial cells, form a functional blood–brain barrier (BBB) in vitro. The ability of FITC-dextran (70 kDa), calcium phosphate nanoparticles (100 nm), Escherichia c...

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