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Organoids, Volume 1, Issue 2

December 2022 - 5 articles

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Articles (5)

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Article

3 Citations

6,739 Views

16 Pages

Pancreatic Cancer 3D Cell Line Organoids (CLOs) Maintain the Phenotypic Characteristics of Organoids and Accurately Reflect the Cellular Architecture and Heterogeneity In Vivo

Sara Noorani,
Shannon R. Nelson,
Neil T. Conlon,
Justine Meiller,
Ekaterina Shcheglova,
Alice Usai,
Jojanneke Stoof,
Letizia Palanga,
Fiona O’Neill and
Sandra Roche
+ 3 authors

Organoids2022, 1(2), 168-183;https://doi.org/10.3390/organoids1020013

12 December 2022

Pancreatic cancer is a highly lethal disease. Therapeutic resistance to chemotherapy is a major cause of treatment failure and recurrence in pancreatic cancer. Organoids derived from cancer stem cells (CSC) are promising models for the advancement of...

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Feature Paper
Review

35 Citations

15,162 Views

19 Pages

3D Tumor Spheroid and Organoid to Model Tumor Microenvironment for Cancer Immunotherapy

Yichen Zhu,
Elliot Kang,
Matthew Wilson,
Taylor Basso,
Evelynn Chen,
Yanqi Yu and
Yan-Ruide Li

Organoids2022, 1(2), 149-167;https://doi.org/10.3390/organoids1020012

5 December 2022

The intricate microenvironment in which malignant cells reside is essential for the progression of tumor growth. Both the physical and biochemical features of the tumor microenvironment (TME) play a critical role in promoting the differentiation, pro...

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Article

25 Citations

5,701 Views

14 Pages

Articular Tissue-Mimicking Organoids Derived from Mesenchymal Stem Cells and Induced Pluripotent Stem Cells

Zhong Alan Li,
Jiangyinzi Shang,
Shiqi Xiang,
Eileen N. Li,
Haruyo Yagi,
Kanyakorn Riewruja,
Hang Lin and
Rocky S. Tuan

Organoids2022, 1(2), 135-148;https://doi.org/10.3390/organoids1020011

14 November 2022

Organoids offer a promising strategy for articular tissue regeneration, joint disease modeling, and development of precision medicine. In this study, two types of human stem cells—primary mesenchymal stem cells (MSCs) and induced pluripotent st...

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Feature Paper
Review

6 Citations

8,083 Views

19 Pages

Meniscus Repair: From In Vitro Research to Patients

Hélène Vignes,
Guillaume Conzatti,
Guoqiang Hua and
Nadia Benkirane-Jessel

Organoids2022, 1(2), 116-134;https://doi.org/10.3390/organoids1020010

2 November 2022

Walking, running, jumping, or even just standing up are habits that we all have to perform in our everyday lives. However, defects in tissues composing the knee joint can drastically alter our ability to complete those simple actions. The knee joint...

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Communication

7 Citations

4,506 Views

10 Pages

Single-Cell Atlas of Patient-Derived Trophoblast Organoids in Ongoing Pregnancies

Olivier J. M. Schäffers,
Catherine Dupont,
Eric M. Bindels,
Diane Van Opstal,
Dick H. W. Dekkers,
Jeroen A. A. Demmers,
Joost Gribnau and
Bas B. van Rijn

Organoids2022, 1(2), 106-115;https://doi.org/10.3390/organoids1020009

2 October 2022

Trophoblast organoids (TOs) hold great promise for elucidating human placental development and function. By deriving TOs in ongoing pregnancies using chorionic villus sampling (CVS), we established a platform to study trophoblast differentiation and...

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