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Gastrointestinal Disorders, Volume 5, Issue 4

December 2023 - 13 articles

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Articles (13)

  • Review
  • Open Access
4 Citations
9,347 Views
29 Pages

Colorectal Cancer Liver Metastasis—State-of-the-Art and Future Perspectives

  • Ana Ruivo,
  • Rui Caetano Oliveira,
  • Pedro Silva-Vaz and
  • José Guilherme Tralhão

The current management of colorectal cancer liver metastasis (CRCLM) patients involves a multidisciplinary approach, with surgical resection remaining the primary curative option. The advances in liver surgery have improved outcomes, enabling more pa...

  • Systematic Review
  • Open Access
5 Citations
4,558 Views
31 Pages

From Algorithms to Clinical Utility: A Systematic Review of Individualized Risk Prediction Models for Colorectal Cancer

  • Deborah Jael Herrera,
  • Wessel van de Veerdonk,
  • Daiane Maria Seibert,
  • Moges Muluneh Boke,
  • Claudia Gutiérrez-Ortiz,
  • Nigus Bililign Yimer,
  • Karen Feyen,
  • Allegra Ferrari and
  • Guido Van Hal

Individualized risk prediction models for colorectal cancer (CRC) play a pivotal role in shaping risk-based screening approaches, garnering attention for use in informed decision making by patients and clinicians. While the incorporation of new predi...

  • Article
  • Open Access
2 Citations
3,894 Views
13 Pages

Protection of Testis against Lipopolysaccharide-Induced Toxicity: Mildronate-Induced L-Carnitine Depletion as a Modulator of Gut Microbiome Composition and Gastrointestinal Inflammation

  • Artem P. Gureev,
  • Polina I. Babenkova,
  • Veronika V. Nesterova,
  • Arina D. Tsvetkova,
  • Mariya V. Gryaznova and
  • Ekaterina A. Shaforostova

L-carnitine plays a critical role in sperm functioning and maintaining male fertility. Mildronate is a widely used drug for treating cardiovascular diseases. Mildronate inhibits L-carnitine biosynthesis and transport into cells while increasing gluco...

  • Review
  • Open Access
6 Citations
7,992 Views
19 Pages

Gut–Brain Axis, Microbiota and Probiotics—Current Knowledge on Their Role in Irritable Bowel Syndrome: A Review

  • Cristina Maria Marginean,
  • Mihaela Popescu,
  • Andrei Ioan Drocas,
  • Sergiu Marian Cazacu,
  • Radu Mitrut,
  • Iulia Cristina Marginean,
  • George Alexandru Iacob,
  • Marian Sorin Popescu,
  • Anca Oana Docea and
  • Paul Mitrut

Irritable bowel syndrome (IBS) is a common digestive disorder with a significant impact on both individuals and society in terms of quality of life and healthcare costs. A growing body of research has identified various communication pathways between...

  • Article
  • Open Access
1 Citations
2,565 Views
9 Pages

Patient-Reported Outcomes and Survival Following Pancreatic Cancer Resection—Results from a Cross-Section Study

  • Clare Toms,
  • Charbel Sandroussi,
  • David Yeo,
  • James Morkaya,
  • Carlo Pulitano and
  • Daniel Steffens

The aims of this study were to assess patient-reported outcomes and the survival of patients following curative resection for pancreas cancer. Adult patients undergoing curative pancreatic resection between April 2014 and April 2019 across six major...

  • Review
  • Open Access
1 Citations
5,619 Views
8 Pages

This review article will address the frequently encountered functional gastrointestinal disorders (FGIDs) occurring in infancy. The clinical features and management of infant regurgitation, infant colic, infant dyschezia, and functional constipation...

  • Article
  • Open Access
1 Citations
2,188 Views
13 Pages

Background: Gastrointestinal adenocarcinomas are a worldwide and some of the most important causes of death related to cancers. MLH1, PMS2, and K-Ras are some of the main molecules responsible for the control of cellular proliferation. They are widel...

  • Article
  • Open Access
1 Citations
2,890 Views
13 Pages

Excessive Glucose and Fructose Intake Aggravates the Pathogenesis of Rat Experimental Colitis

  • Kohki Okada,
  • Kano Matsuo,
  • Miku Amada,
  • Saki Kashihara,
  • Koto Katsuragi,
  • Miharu Doumae,
  • Masaki Moriwaki,
  • Ryouhei Yamauchi and
  • Jun Yoshida

Ulcerative colitis (UC) is a relapsing and remitting disease that causes chronic inflammation and ulceration of colonic tissue, especially in the rectum region. Although sugars are rapidly digested and absorbed and can be efficiently utilized as ener...

  • Article
  • Open Access
11 Citations
3,629 Views
10 Pages

Low Short-Chain-Fatty-Acid-Producing Activity of the Gut Microbiota Is Associated with Hypercholesterolemia and Liver Fibrosis in Patients with Metabolic-Associated (Non-Alcoholic) Fatty Liver Disease

  • Xinlu Cao,
  • Oksana Zolnikova,
  • Roman Maslennikov,
  • Maria Reshetova,
  • Elena Poluektova,
  • Arina Bogacheva,
  • Maria Zharkova and
  • Vladimir Ivashkin

The aim of this study was to investigate the short-chain fatty acid (SCFA) activity of the gut microbiota of patients with metabolic-associated fatty liver disease (MAFLD). The level and spectrum of short-chain fatty acids (SCFAs) were determined via...

  • Article
  • Open Access
3 Citations
3,262 Views
9 Pages

Incidence, Clinicopathological Features and Oncologic Outcome of Appendiceal Neoplasms: A Single-Center Cohort Study

  • Ferney David Gómez-Báez,
  • Carlos Cerdán-Santacruz,
  • Naroa Moreno Muguiro,
  • Lucía Milla Collado,
  • Mireia Merichal Resina,
  • Jordi Antoni Tarragona Foradada,
  • José Enrique Sierra Grañón and
  • Jorge Juan Olsina Kissler

Appendiceal tumors represent a large amalgam of different tumor lineages. The continuous evolution in their pathological classifications has led to some variable recommended attitudes over time. The aim of this study is to review the incidence, clini...

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Gastrointest. Disord. - ISSN 2624-5647