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Precision Medicine in Non-Communicable Diseases
1
Department of Biomedicine & Prevention, Genetics Unit, University of Rome “Tor Vergata”, 00133 Rome, Italy
2
IRCCS Neuromed, 86077 Pozzilli (IS), Italy
3
Department of Pharmacology, School of Medicine, University of Nevada, Reno, NV 89557, USA
4
Department of Biology, University of Rome “Tor Vergata”, 00133 Rome, Italy
5
Department of Neurology and Neurosurgery, Peoples’ Friendship University of Russia (RUDN University), Moscow 117198, Russia
6
Imperial College, Faculty of Medicine, School of Public Health, SW7 2AZ London, UK
*
Author to whom correspondence should be addressed.
High-Throughput 2020, 9(1), 3; https://doi.org/10.3390/ht9010003
Received: 30 November 2019
/
Revised: 31 December 2019
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Accepted: 4 February 2020
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Published: 7 February 2020
(This article belongs to the Special Issue Selected Papers from 1st International and 32nd Annual Conference of Italian Association of Cell Culture)
The increase in life expectancy during the 20th century ranks as one of society’s greatest achievements, with massive growth in the numbers and proportion of the elderly, virtually occurring in every country of the world. The burden of chronic diseases is one of the main consequences of this phenomenon, severely hampering the quality of life of elderly people and challenging the efficiency and sustainability of healthcare systems. Non-communicable diseases (NCDs) are considered a global emergency responsible for over 70% of deaths worldwide. NCDs are also the basis for complex and multifactorial diseases such as hypertension, diabetes, and obesity. The epidemics of NCDs are a consequence of a complex interaction between health, economic growth, and development. This interaction includes the individual genome, the microbiome, the metabolome, the immune status, and environmental factors such as nutritional and chemical exposure. To counteract NCDs, it is therefore essential to develop an innovative, personalized, preventative, early care model through the integration of different molecular profiles of individuals to identify both the critical biomarkers of NCD susceptibility and to discover novel therapeutic targets.
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Keywords:
precision medicine; genomics; epigenetics; pharmacogenetics; genomic biomarkers
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MDPI and ACS Style
Novelli, G.; Biancolella, M.; Latini, A.; Spallone, A.; Borgiani, P.; Papaluca, M. Precision Medicine in Non-Communicable Diseases. High-Throughput 2020, 9, 3. https://doi.org/10.3390/ht9010003
AMA Style
Novelli G, Biancolella M, Latini A, Spallone A, Borgiani P, Papaluca M. Precision Medicine in Non-Communicable Diseases. High-Throughput. 2020; 9(1):3. https://doi.org/10.3390/ht9010003
Chicago/Turabian StyleNovelli, Giuseppe, Michela Biancolella, Andrea Latini, Aldo Spallone, Paola Borgiani, and Marisa Papaluca. 2020. "Precision Medicine in Non-Communicable Diseases" High-Throughput 9, no. 1: 3. https://doi.org/10.3390/ht9010003
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