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Proceedings 2017, 1(10), 1028;

Antiproliferative Effect of Methanolic Extract of Linum arboreum on A549 Cells

Department of Biology, Science and Art Faculty, Uludag University, Bursa 16059, Turkey
Presented at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy, Kayseri, Turkey, 8–11 November 2017.
Author to whom correspondence should be addressed.
Published: 14 November 2017
PDF [149 KB, uploaded 14 November 2017]


Many anticancer drugs in clinical use are natural product derived from natural sources. Today, investigations of anti cancer effect of different natural products are increase. The aimed of the current study was to investigate possible antiproliferative effects of methanolic extract of Linum arboreum leaves (MELAL) and fruits (MELAF). Linumarboreum is a plant species that member of Linacea efamily. We evaluated the antiproliferative effect of MELAL and MELAF on human lung carcinomacells A549 by XTT assay. Cells exposed different concentration of MELAL and MELAF (0.1–2000 µg/mL) for 24 h. IC50 value was determined 0.771 ± 0.043 µg/mL of MELAL and IC50 value was determined 1.456 ± 0.995 µg/mL of MELAF. MELAL has shown higher antiproliferative activity compare with MELAF. Alsoboth of MELAL and MELAF have higher antiproliferative activity with low IC50 values in compared cisplatin. Especially MELAL has shown strong anticancer activity with low IC50 value. Nevertheless, anti cancer activity of MELAL should be supported by further studies.
Keywords: Linumarboreum; XTT; A549 Linumarboreum; XTT; A549
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Vatan, O.; Yılmaz, O.; Huriyet, H.; Cavas, T.; Cinkılıç, N. Antiproliferative Effect of Methanolic Extract of Linum arboreum on A549 Cells. Proceedings 2017, 1, 1028.

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