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Tropical Medicine and Infectious Disease, Volume 10, Issue 4

2025 April - 33 articles

Cover Story: Leprosy is a chronic, debilitating and stigmatising mycobacterial disease with a long incubation period. In 2008, the landmark COLEP study showed that single-dose rifampicin post-exposure prophylaxis (PEP) given to close contacts of leprosy cases led to a 57% overall reduction in subsequent leprosy incidence. Since then, further studies on leprosy PEP have been conducted. This review presents evidence for the efficacy, safety and feasibility of various rifamycin-based chemoprophylaxis strategies. Current evidence suggests that rifamycin-based leprosy PEP is feasible, safe, cost-effective and acceptable to both patients with leprosy and their contacts. Additional research is needed to optimise PEP regimens while ensuring adequate monitoring for potential intervention-related harm. View this paper
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Articles (33)

  • Article
  • Open Access
2 Citations
3,148 Views
14 Pages

Desiccation Tolerance of Aedes aegypti and Aedes albopictus Eggs of Northeastern Argentina Origin

  • Mía E. Martín,
  • Elizabet L. Estallo,
  • Luis G. Estrada,
  • Carolina Matiz Enriquez and
  • Marina Stein

This study examines the desiccation tolerance of Aedes aegypti and Aedes albopictus eggs, two major arbovirus vectors, in a subtropical region of Argentina to understand their survival under varying relative humidity (RH) conditions (35%, 68%, and 82...

  • Review
  • Open Access
2 Citations
1,670 Views
11 Pages

The State of Antimicrobial Resistance of Gram-Negative Bacilli in Canada

  • Jeremy Li,
  • Andrew Walkty,
  • Philippe Lagacé-Wiens,
  • James Karlowsky and
  • George Zhanel

In the last two decades, there has been an increase in resistance among Gram-negative bacteria in Canada. From 2007 to 2016, the proportion of ESBL-producing isolates among Escherichia coli and Klebsiella pneumoniae isolates increased from 3.5% to 11...

  • Article
  • Open Access
2 Citations
2,437 Views
15 Pages

Qualitative Study of Nutritional Support-Related Perceptions and Preferences Among Persons Affected by TB, Family Caregivers, and Healthcare Providers in India

  • Balaji Ramraj,
  • Karikalan Nagarajan,
  • Debjani Ram Purakayastha,
  • Major Madhukar,
  • Makesh Kumar,
  • Neha Raj,
  • Sarath Kumar,
  • Banappa S. Unger,
  • Nithin Rajamani and
  • Chandrasekaran Padmapriyadarsini
  • + 7 authors

Evidence on the implementation aspects of nutritional support interventions for persons with TB in India is limited. This qualitative study employed focus group discussions with persons with TB (n = 71), their family caregivers (n = 17), and healthca...

  • Systematic Review
  • Open Access
2 Citations
3,555 Views
19 Pages

Prevalence of Trichomonas vaginalis Among Women in the Chinese Population: A Systematic Review and Meta-Analysis

  • Shuang Li,
  • Jiahui Xu,
  • Sisi Ru,
  • Changjun Hu,
  • Chongyang Liu,
  • Xingquan Sun,
  • Heteng Guo and
  • Xi Zhang

Trichomonas vaginalis (TV) is the most common non-viral sexually transmitted infection (STI) among women worldwide. However, there is little information available regarding the burden of trichomoniasis infection among Chinese women. The aim of the pr...

  • Article
  • Open Access
3,461 Views
14 Pages

Infectivity and Dissemination of Dengue Virus-1 in Different Aedes aegypti Populations Throughout Brazil

  • Amanda Cupertino de Freitas,
  • Ellen Santos,
  • Lívia Baldon,
  • Silvana de Mendonça,
  • Fernanda Oliveira Rezende,
  • Rafaela Moreira,
  • Viviane Sousa,
  • Mariana Lima,
  • Emanuele Silva and
  • Alvaro Ferreira
  • + 13 authors

Dengue virus, one of the most prevalent mosquito-borne flaviviruses affecting humans globally, is primarily transmitted by the Aedes aegypti mosquito, which thrives in densely populated urban environments. Dengue incidence has surged in recent decade...

  • Article
  • Open Access
1,796 Views
16 Pages

The Incidence of Scabies in Far North Queensland, Tropical Australia: Implications for Local Clinical Practice and Public Health Strategies

  • Mert Hamdi Korkusuz,
  • Maria Eugenia Castellanos,
  • Linton R. Harriss,
  • Allison Hempenstall,
  • Simon Smith and
  • Josh Hanson

The recognition and treatment of scabies has been incorporated into Australian guidelines for the prevention of acute rheumatic fever (ARF) and rheumatic heart disease (RHD). The incidence of both diagnosed ARF and RHD is increasing in Far North Quee...

  • Case Report
  • Open Access
1 Citations
3,183 Views
10 Pages

Non-O1, Non-O139 Vibrio cholerae Bacteremic Skin Infection with Multiple Skin Necrosis: Case Report

  • Amer Ibrahim Alomar,
  • Nasreldin Elhadi,
  • Lamya Zohair Yamani,
  • Reema Allahham,
  • Rana Alghamdi,
  • Ibrahim Alhabib,
  • Asim Diab,
  • Nehal Mahmoud,
  • Bashayer AlDossary and
  • Reem Al Jindan
  • + 3 authors

Non-O1, non-O139 Vibrio cholerae (NOVC) extraintestinal infections are rare, but recently, several clinical incidents have been reported worldwide. Toxigenic V. cholerae is a well-known etiological agent of cholera, responsible for acute dehydrating...

  • Article
  • Open Access
1 Citations
1,848 Views
18 Pages

Phylogeographic Patterns and Genetic Diversity of Anopheles stephensi: Implications for Global Malaria Transmission

  • Jehangir Khan,
  • Dongjing Zhang,
  • Saber Gholizadeh,
  • Yidong Deng,
  • Abdul Aziz,
  • Jianhuang Chen,
  • Pir Tariq Shah,
  • Zhiyue Lv and
  • Tao Chen

Background: Anopheles stephensi, a primary malaria vector in South Asia, is expanding its geographic range, raising concerns about increased malaria transmission. However, critical aspects of its genetic diversity, population structure, and evolution...

  • Article
  • Open Access
3,034 Views
11 Pages

Background: From 2018 to 2021, travel-related extensively drug-resistant (XDR) Salmonella Typhi was identified in Ontario, Canada. Opportunities remain to characterize typhoidal Salmonella antimicrobial susceptibility trends (including multi-drug res...

  • Case Report
  • Open Access
1,198 Views
7 Pages

Osteomyelitis caused by Moesziomyces aphidis is exceedingly rare and, to our knowledge, has not been previously reported in immunocompetent individuals. This case represents the first documented instance. A 19-year-old woman developed osteomyelitis f...

  • Article
  • Open Access
1 Citations
2,750 Views
11 Pages

Treatment-Decision Algorithm of Child TB: Evaluation of WHO Algorithm and Development of Indonesia Algorithm

  • Rina Triasih,
  • Finny Fitry Yani,
  • Diah Asri Wulandari,
  • Betty Weri Yolanda Nababan,
  • Muhammad Buston Ardiyamustaqim,
  • Fransiska Meyanti,
  • Sang Ayu Kompiyang Indriyani,
  • Tiffany Tiara Pakasi and
  • Ery Olivianto

Clinical algorithms for child tuberculosis (TB) are a valuable guide for healthcare workers to initiate treatment. We evaluated the agreement of pediatric TB diagnosis using the current Indonesia diagnostic algorithms with the 2022 WHO treatment deci...

  • Review
  • Open Access
3 Citations
2,051 Views
12 Pages

Antibiotic resistance is a public health emergency, with ten million deaths estimated annually by the year 2050. Water systems are an important medium for the development and dissemination of antibiotic resistance from a variety of sources, explored...

  • Brief Report
  • Open Access
1,861 Views
9 Pages

Detection of Trypanosoma cruzi in a Reactive Blood Bank Sample in Sonora, Mexico

  • Idalia Paredes-Sotelo,
  • Mónica Reséndiz-Sandoval,
  • Adriana Garibay-Escobar,
  • Edgar Alfonso Paredes-González,
  • Aracely Angulo-Molina,
  • Angel Ramos-Ligonio,
  • Eric Dumonteil,
  • Claudia Herrera and
  • Olivia Valenzuela

Chagas disease is a neglected disease caused by the parasite Trypanosoma cruzi, a public health problem in both endemic and non-endemic countries. In Mexico, the southern region is considered endemic, and cases are frequently reported; however, in th...

  • Article
  • Open Access
3 Citations
3,608 Views
15 Pages

Using a Machine Learning Approach to Predict Snakebite Envenoming Outcomes Among Patients Attending the Snakebite Treatment and Research Hospital in Kaltungo, Northeastern Nigeria

  • Nicholas Amani Hamman,
  • Aashna Uppal,
  • Nuhu Mohammed,
  • Abubakar Saidu Ballah,
  • Danimoh Mustapha Abdulsalam,
  • Frank Mela Dangabar,
  • Nuhu Barde,
  • Bello Abdulkadir,
  • Suraj Abdullahi Abdulkarim and
  • Joshua Abubakar Difa
  • + 3 authors

The Snakebite Treatment and Research Hospital (SBTRH) is a leading centre for snakebite envenoming care and research in sub-Saharan Africa, treating over 2500 snakebite patients annually. Despite routine data collection, routine analyses are seldom c...

  • Article
  • Open Access
3 Citations
2,314 Views
15 Pages

Community-Based Tuberculosis Preventive Treatment Among Child and Adolescent Household Contacts in Ethiopia

  • Eshetu Abelti,
  • Zewdu Dememew,
  • Asfawesen Gebreyohannes,
  • Yohannes Alemayehu,
  • Tilay Terfassa,
  • Taye Janfa,
  • Degu Jerene,
  • Pedro Suarez and
  • Daniel Datiko

There are limited studies on the community-based outcomes of tuberculosis (TB) preventive treatment (TPT) among children and adolescent contacts <15 years in Ethiopia. Our objective was to assess TPT uptake and completion rates among eligible unde...

  • Article
  • Open Access
2 Citations
1,130 Views
24 Pages

Breaking the Cycle of Echinococcosis: A Mathematical Modeling Approach

  • Richard Lagos,
  • Juan Pablo Gutiérrez-Jara,
  • Beatriz Cancino-Faure,
  • Leidy Yissedt Lara-Díaz,
  • Ignacio Barradas and
  • Andrei González-Galeano

This study presents a mathematical model of the transmission and spread of the Echinococcus granulosus parasite. The model incorporates host mobility, laws governing the dynamics of Echinococcosis transmission between hosts, and control and preventio...

  • Article
  • Open Access
2 Citations
9,136 Views
12 Pages

HPV Genotype Trends in Iran: Necessity for a Reevaluation of Prevention Strategies

  • Maryam Shahi,
  • Azam Shafaei,
  • Mohamad Ghodsi,
  • Reza Jafarzadeh Esfehani and
  • Mahdi Moradi Marjaneh

Introduction: Human papillomavirus (HPV) genotyping is critical for preventing and managing HPV-related health issues, including cancers. This study re-evaluates HPV genotype trends in Iran to inform prevention strategies. Materials and Methods: A cr...

  • Article
  • Open Access
4 Citations
1,800 Views
12 Pages

Prognostic Value of Ratios of Inflammatory Markers in the Prognosis of Crimean–Congo Hemorrhagic Fever

  • Mürşit Hasbek,
  • Yasemin Çakır Kıymaz,
  • Seyit Ali Büyüktuna and
  • Hayrettin Yavuz

Crimean–Congo hemorrhagic fever (CCHF) is a tick-borne zoonotic disease, causing clinical presentations ranging from asymptomatic infection to fatal viral hemorrhagic fever. Throughout the course of CCHF, the levels of certain biomarkers, such...

  • Article
  • Open Access
1 Citations
1,563 Views
16 Pages

Vitamin D Status and Incidence of SARS-CoV-2 Reinfections in the Borriana COVID-19 Cohort: A Population-Based Prospective Cohort Study

  • Salvador Domènech-Montoliu,
  • Laura López-Diago,
  • Isabel Aleixandre-Gorriz,
  • Óscar Pérez-Olaso,
  • Diego Sala-Trull,
  • Alba Del Rio-González,
  • Maria Rosario Pac-Sa,
  • Manuel Sánchez-Urbano,
  • Paloma Satorres-Martinez and
  • Alberto Arnedo-Pena
  • + 7 authors

A deficient vitamin D (VitD) status has been associated with SARS-CoV-2 infections, severity, and mortality. However, this status related to SARS-CoV-2 reinfections has been studied little. Our aim was to quantify the risk of reinfections considering...

  • Article
  • Open Access
1,682 Views
11 Pages

COVID-19 in Morocco: Nurses’ Knowledge of Anti-COVID-19 Vaccines and Their Involvement in Vaccine Vigilance

  • Fatima Zahra Laamiri,
  • Manar Aarrad,
  • Abdelmounaim Manoussi,
  • Youssef Baba Khouya,
  • Fatine Hadrya,
  • Mohamed Chahboune and
  • Amina Barkat

The COVID-19 pandemic has highlighted the crucial role of nurses in managing health crises, particularly in implementing vaccination campaigns launched in many countries worldwide. This descriptive study assesses nurses’ knowledge of COVID-19 v...

  • Case Report
  • Open Access
1 Citations
1,269 Views
7 Pages

Tuberculous Meningitis in a Child: A Rare Presentation of Cytotoxic Lesion of the Corpus Callosum

  • Ny Thi Hong Tran,
  • Nhung Thi Hong Nguyen,
  • Uyen Phuong Vo and
  • Julie Huynh

Tuberculous meningitis (TBM) is the most severe form of tuberculosis, disproportionately affecting vulnerable populations such as young children and people living with human immunodeficiency virus (HIV). Major challenges to accurate and early diagnos...

  • Article
  • Open Access
2 Citations
3,110 Views
19 Pages

One Health Lens on Rabies: Human–Bat Interactions and Genomic Insights of Rabies Virus in Rural Lilongwe, Malawi

  • Nathan Singano,
  • Henson Kainga,
  • Elisha Chatanga,
  • Joseph Nkhoma,
  • Gilson Njunga,
  • Julius Chulu,
  • Rabecca Tembo,
  • Hirofumi Sawa and
  • Walter Muleya

Rabies, a fatal zoonotic disease, affects humans, domestic animals, and wildlife predominantly in Africa, Asia, and Latin America. In Malawi, rabies virus (RABV) is primarily transmitted by infected dogs, impacting humans and cattle. Lyssavirus has a...

  • Review
  • Open Access
1 Citations
3,743 Views
25 Pages

Combating Malaria: Targeting the Ubiquitin-Proteasome System to Conquer Drug Resistance

  • Bazgha Sanaullah,
  • Nguyen Van Truong,
  • Tuyet-Kha Nguyen and
  • Eun-Taek Han

Malaria primarily affects developing nations and is one of the most destructive and pervasive tropical parasite infections. Antimalarial drug resistance, characterized by a parasite’s ability to survive and reproduce despite recommended medicat...

  • Article
  • Open Access
2 Citations
2,267 Views
17 Pages

Leveraging Artificial Intelligence to Predict Potential TB Hotspots at the Community Level in Bangui, Republic of Central Africa

  • Kobto G. Koura,
  • Sumbul Hashmi,
  • Sonia Menon,
  • Hervé G. Gando,
  • Aziz K. Yamodo,
  • Anne-Laure Budts,
  • Vincent Meurrens,
  • Saint-Cyr S. Koyato Lapelou,
  • Olivia B. Mbitikon and
  • Caroline Van Cauwelaert
  • + 1 author

Tuberculosis (TB) is a global health challenge, particularly in the Central African Republic (CAR), which is classified as a high TB burden country. In the CAR, factors like poverty, limited healthcare access, high HIV prevalence, malnutrition, inade...

  • Article
  • Open Access
1 Citations
3,372 Views
14 Pages

Baseline Seroprevalence of Arboviruses in Liberia Using a Multiplex IgG Immunoassay

  • Albert To,
  • Varney M. Kamara,
  • Davidetta M. Tekah,
  • Mohammed A. Jalloh,
  • Salematu B. Kamara,
  • Teri Ann S. Wong,
  • Aquena H. Ball,
  • Ludwig I. Mayerlen,
  • Kyle M. Ishikawa and
  • Axel T. Lehrer
  • + 8 authors

Insect-borne viruses may account for a significant proportion of non-malaria and non-bacterial febrile illnesses in Liberia. Although the presence of many arthropod vectors has been documented, the collective burden of arbovirus infections and baseli...

  • Article
  • Open Access
1 Citations
4,026 Views
12 Pages

Strongyloidiasis Treatment Outcomes: A Prospective Study Using Serological and Molecular Methods

  • Ana Lucas Dato,
  • Philip Wikman-Jorgensen,
  • José María Saugar Cruz,
  • Elisa García-Vázquez and
  • Jara Llenas-García

Strongyloidiasis, caused by the soil-transmitted helminth Strongyloides stercoralis, is estimated to infect around 600 million people worldwide. Ivermectin is the current first-line treatment. This prospective study evaluated long-term treatment resp...

  • Perspective
  • Open Access
3 Citations
3,281 Views
16 Pages

Building Pathogen Genomic Sequencing Capacity in Africa: Centre for Epidemic Response and Innovation Fellowship

  • Eric Agboli,
  • Molalegne Bitew,
  • Christian N. Malaka,
  • Tiangay M. P. S. Kallon,
  • Alhaji M. S. Jalloh,
  • Baron Yankonde,
  • Doreen M. Shempela,
  • Jay F. M. Sikalima,
  • Mutale Joseph and
  • Monika Moir
  • + 26 authors

The World Health Organization African region has the greatest infectious disease burden in the world. However, many African countries have limited capacity to rapidly detect, report, and respond to public health events. The Centre for Epidemic Respon...

  • Review
  • Open Access
3 Citations
2,771 Views
11 Pages

Malaria has been and remains a significant challenge in Africa and other endemic settings. Roughly, 95% of global morbidity and mortality due to malaria occurs within African populations and affects millions of individuals, especially those living in...

  • Article
  • Open Access
1 Citations
1,616 Views
17 Pages

Epidemiological Scenario of American Trypanosomiasis and Its Socioeconomic and Environmental Relations, Pará, Eastern Brazilian Amazon

  • Claudia do Socorro Carvalho Miranda,
  • Bruna Costa de Souza,
  • Tainara Carvalho Garcia Miranda Filgueiras,
  • João Simão de Melo Neto,
  • Amanda Sophia Carvalho Miranda da Silva,
  • Hilton Pereira da Silva,
  • Marcos Valério Santos da Silva,
  • Frederico Itã Mateus Carvalho Oliveira Miranda,
  • Edilene do Socorro Nascimento Falcão Sarges and
  • Nelson Veiga Gonçalves
  • + 2 authors

Chagas disease is a serious public health problem worldwide. In Brazil, the state of Pará has the largest number of reported cases. This article analyzes the spatial distribution of this disease and its relationship with socioeconomic, environ...

  • Systematic Review
  • Open Access
6 Citations
2,725 Views
24 Pages

This systematic review and meta-analysis aims to: (1) characterize the distribution of published inhibition of emergence (IE50, IE90, and IE95) reference values for pyriproxyfen and methoprene in Culex pipiens [L.], Aedes aegypti [L.], and Aedes albo...

  • Systematic Review
  • Open Access
1 Citations
1,990 Views
17 Pages

Neonatal Mucormycosis: A Rare but Highly Lethal Fungal Infection in Term and Preterm Newborns—A 20-Year Systematic Review

  • Alfredo Valdez-Martinez,
  • Mónica Ingrid Santoyo-Alejandre,
  • Roberto Arenas,
  • Claudia Erika Fuentes-Venado,
  • Tito Ramírez-Lozada,
  • Fernando Bastida-González,
  • Claudia Camelia Calzada-Mendoza,
  • Erick Martínez-Herrera and
  • Rodolfo Pinto-Almazán

Background/Objectives: Mucormycosis is a rare but life-threatening fungal infection, particularly in neonates, due to their undeveloped immune system. This systematic review aims to analyze the risk factors, clinical presentations, treatments, and ou...

  • Article
  • Open Access
2,150 Views
13 Pages

Schistosomiasis and Soil Transmitted Helminthiasis Among School Age Children: Impact of 3–5 Annual Rounds of Mass Drug Administration in Ekiti State, Southwest Nigeria

  • Solomon Monday Jacob,
  • Jan-Carel Diehl,
  • Gleb Vdovine,
  • Temitope Agbana,
  • Samuel Popoola,
  • Satyajith Jujjavarapu,
  • David Bell,
  • Akande Oladimeji Ajayi,
  • Joseph O. Fadare and
  • Louise Makau-Barasa
  • + 4 authors

Background: Schistosomiasis (SCH) and soil transmitted helminthiasis (STH) have been targeted for elimination as a public health problem (EPHP) within the World Health Organization (WHO)’s Roadmap for Neglected Tropical Diseases (NTDs) 2021&nda...

  • Review
  • Open Access
1 Citations
3,025 Views
20 Pages

In 2021, the World Health Organization (WHO) recommended scaling up leprosy prevention activities, including chemoprophylaxis, as one of the pillars of their ‘Towards Zero Leprosy’ strategy. This recommendation was primarily based on a 57...

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Trop. Med. Infect. Dis. - ISSN 2414-6366