Journal of Mind and Medical Sciences

6 pages, 266 KiB

Open AccessCase Report

A Pedunculated Esophageal Chondromatous Hamartoma in a Child

by Dan-Alexandru Iozsa, Maria Puscasu, Catalin Gabriel Cirstoveanu, Vlad Denis Constantin, Anca Silvia Dumitriu, Stana Paunica and Nicolae Sebastian Ionescu

J. Mind Med. Sci. 2021, 8(1), 161-166; https://doi.org/10.22543/7674.81.P161166 - 8 Apr 2021

Viewed by 77

Abstract

Esophageal tumors are uncommon in pediatric population and most of them are benign. Esophageal hamartomas have been reported extremely rare in children. These can present as intramural tumors of the esophageal wall or as polyps. Dysphagia is the main symptom described in their [...] Read more.

Esophageal tumors are uncommon in pediatric population and most of them are benign. Esophageal hamartomas have been reported extremely rare in children. These can present as intramural tumors of the esophageal wall or as polyps. Dysphagia is the main symptom described in their case, but other specific symptoms are also reported. Such symptoms encountered in clinical practice are represented by obstructive apnea episodes and bradycardia, poor weight gain, epigastric or retrosternal pain, hematemesis or melena, dysphonia or tracheal sounds. Diagnosis can be delayed due to the insidious onset and non-specific symptoms, therefore patient’s compliance to follow-up and broad, careful evaluation are mandatory. Preoperative imagistic assessment is extremely important for a precise definition of the tumor’s anatomical relations, especially when facing large tumors located in the posterior mediastinum. Herein we report a case of a large chondromatous polypoid hamartoma of the esophagus in a 9 years old boy, emphasizing over the diagnosis and surgical challenges we have met, along with comments on illustrative similar cases reported in the literature. Full article

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7 pages, 405 KiB

Open AccessCase Report

Postoperative Complicated Appendectomy Revealing Crohn’s Disease in a Pediatric Patient

by Augustina Enculescu, Mircea Denis Lupusoru, Catalin Cirstoveanu, Andra-Iulia Suceveanu, Liliana Florina Andronache, Adrian-Paul Suceveanu, Felix Voinea and Maria Puscasu

J. Mind Med. Sci. 2021, 8(1), 154-160; https://doi.org/10.22543/7674.81.P154160 - 8 Apr 2021

Cited by 1 | Viewed by 102

Abstract

Granulomatous appendicitis is a very rare entity in children. It is related to Crohn’s disease in only 5–10% of the cases. The diagnosis of Crohn’s disease is a real challenge in the pediatric population, especially when its initial manifestation is acute appendicitis. Herein, [...] Read more.

Granulomatous appendicitis is a very rare entity in children. It is related to Crohn’s disease in only 5–10% of the cases. The diagnosis of Crohn’s disease is a real challenge in the pediatric population, especially when its initial manifestation is acute appendicitis. Herein, we present a 13-year-old boy admitted for acute appendicitis. The histopathological examination was conclusive for acute granulomatous appendicitis. The development of an entero-cutaneous fistula has complicated the postoperative evolution. The failure of the conservative management required ileocecal resection. The pathological examination revealed Crohn’s disease. The one-year follow-up on the patient din not reveal any complications. We strongly support the importance of the histopathological examination of the entirely removed appendix. Careful assessment of granulomatous appendicitis is needed in order to establish its possible etiology and to initiate the adequate treatment. Full article

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5 pages, 172 KiB

Open AccessCase Report

Acute Chylous Peritonitis Due to Idiopathic Pancreatitis Mimicking Acute Appendicitis

by Dan Bratu, Alin Mihetiu, Dragoș Virgil Davițoiu, Vlad Dumitru Băleanu, Liliana Florina Andronache and Oana Popescu

J. Mind Med. Sci. 2021, 8(1), 149-153; https://doi.org/10.22543/7674.81.P149153 - 8 Apr 2021

Cited by 2 | Viewed by 97

Abstract

The acute development and the accumulation of chyle into the peritoneal space is a rare condition and one needs to be able to distinguish it from chylous ascites, which is most commonly chronic and associated with related diseases. It is frequently idiopathic and [...] Read more.

The acute development and the accumulation of chyle into the peritoneal space is a rare condition and one needs to be able to distinguish it from chylous ascites, which is most commonly chronic and associated with related diseases. It is frequently idiopathic and additionally, clinical and imaging findings are nonspecific. In almost all cases, the diagnosis is made intraoperatively during laparoscopy or laparotomy, most diagnostic procedures being indicated by acute complaints pertaining to the abdomen. A 23-year-old man was admitted to the Emergency Department with abdominal pain, with right iliac fossa tenderness and peritonism. Laparoscopy was performed due to acute abdomen findings. Further exploration revealed chylous effusion with milky-like fluid. The peritoneal lavage and the insertion of drains were subsequent to the careful inspection of the cavity. The biochemical analysis of the peritoneal fluid was an important aid which provided the diagnosis of chylous peritonitis due to acute pancreatitis. Full article

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10 pages, 307 KiB

Open AccessArticle

The Crosstalk Between Insulin Resistance, Systemic Inflammation, Redox Imbalance and the Thyroid in Subjects with Obesity

by Nicoleta Răcătăianu, Nicoleta Valentina Leach, Sorana D. Bolboacă, Maria Loredana Soran, Mirela Flonta, Ana Valea, Andrada-Luciana Lazăr and Cristina Ghervan

J. Mind Med. Sci. 2021, 8(1), 139-148; https://doi.org/10.22543/7674.81.P139148 - 8 Apr 2021

Cited by 3 | Viewed by 100

Abstract

We aimed at assessing the interaction between visceral adipose tissue (VAT), insulin resistance (IR), circulating levels of monocyte chemoattractant protein-1 (MCP-1) and malondialdehyde (MDA) and the thyroid parameters in obese subjects. Methods. Obese subjects without thyroid pathologies or diseases associated with systemic inflammation [...] Read more.

We aimed at assessing the interaction between visceral adipose tissue (VAT), insulin resistance (IR), circulating levels of monocyte chemoattractant protein-1 (MCP-1) and malondialdehyde (MDA) and the thyroid parameters in obese subjects. Methods. Obese subjects without thyroid pathologies or diseases associated with systemic inflammation and OS were recruited. Insulinemia, visceral fat thickness, metabolic and thyroid parameters were assayed. Circulating levels of MCP-1 and MDA were used to quantify inflammation and OS. Results. A number of 160 obese subjects were included. The MCP-1 level increased with the degree of obesity and HOMA-IR. MCP 1 was positively associated with antithyroperoxidase antibody (TPOab) levels and the frequency of Hashimoto’s thyroiditis (HT). The MDA level was positively correlated with the degree of obesity, aspartate aminotransferase and MCP-1. MDA was an independent predictor for the occurrence of hypothyroidism. IR patients showed higher fT3 levels and a positive association between insulin and TPOab levels. Conclusions. Systemic inflammation increased with VAT, IR and OS and was correlated with the frequency and the severity of HT, suggesting that, in obesity, MCP-1 could be part of the etiopathogenesis of autoimmune thyroiditis. MDA was an independent risk factor for hypothyroidism; therefore, redox imbalance associated with obesity can produce cell damage and thyroid dysfunction. FT3 is increased in IR patients, thus being a marker for the severity of metabolic impairment. Full article

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6 pages, 227 KiB

Open AccessArticle

D-Dimer Levels and Acute Pulmonary Embolism Development in COVID-19 Patients

by Vural Ahmet and Kahraman Ahmet Nedim

J. Mind Med. Sci. 2021, 8(1), 133-138; https://doi.org/10.22543/7674.81.P133138 - 8 Apr 2021

Cited by 4 | Viewed by 90

Abstract

Objective. To identify those who develop pulmonary embolism with Ddimer levels by evaluating pulmonary CT angiographies of patients who are followed up with suspicion of coronavirus disease 2019 (COVID-19). Methods. Patients who were followed up in a community hospital with suspicion of COVID-19 [...] Read more.

Objective. To identify those who develop pulmonary embolism with Ddimer levels by evaluating pulmonary CT angiographies of patients who are followed up with suspicion of coronavirus disease 2019 (COVID-19). Methods. Patients who were followed up in a community hospital with suspicion of COVID-19 and underwent Pulmonary CT angiography examination were evaluated. Clinical and demographic parameters and DDimer values for patients with and without pulmonary embolism were evaluated in the pulmonary CT angiogram. Results. During the COVID-19 pandemic, Thorax CT examination was performed in our center for suspicion or follow-up of COVID-19 infection in 3396 patients. Pulmonary CT angiography was applied to 312 (9.2%) of these cases. Of these 312 patients, 141 were identified as COVID-19 patients. Acute pulmonary embolism was detected in 33 (23.4%) of 141 patients with COVID-19 and pulmonary CT angiogram. D-dimer levels (5964.97 ± 4036.8 μg/L) of patients with COVID-19 infection and pulmonary embolism were significantly higher than D-dimer levels (972.4 ± 1766.8 μg/L) of patients without pulmonary embolism. In patients with COVID-19 infection, a Ddimer value higher than 1013 μg/L was determined as a cut-off value with 100% sensitivity for the presence of pulmonary embolism. Conclusions. For those struggling with the COVID-19 pandemic, pulmonary embolism should be kept in mind if D-dimer values increase more than expected in the presence of respiratory distress that Thorax CT findings cannot explain. Full article

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6 pages, 228 KiB

Open AccessArticle

Caesarean Section Versus Vaginal Birth in the Perception of Woman Who Gave Birth by Both Methods

by Octavian Gabriel Olaru, Anca Daniela Stanescu, Cristina Raduta, Liana Ples, Adriana Vasilache, Nicolae Bacalbasa, Andrei Vasilache and Oana Denisa Balalau

J. Mind Med. Sci. 2021, 8(1), 127-132; https://doi.org/10.22543/7674.81.P127132 - 8 Apr 2021

Cited by 4 | Viewed by 92

Abstract

The increase in the number of births by Caesarean section is a phenomenon whose global expansion is generated by numerous factors and especially by the contemporary perceptions of women regarding childbirth meeting the interests of the professionals in the field. However, the opinion [...] Read more.

The increase in the number of births by Caesarean section is a phenomenon whose global expansion is generated by numerous factors and especially by the contemporary perceptions of women regarding childbirth meeting the interests of the professionals in the field. However, the opinion of many women towards the benefits of Caesarean delivery is often not based on the experience or information from reliable sources. This study aimed at sharing the experience of women who gave birth both vaginally and by Caesarean section, focusing on their perception of these events. The study included 26 women and the conclusion of the vast majority (77%) was that natural birth is preferable and they would recommend it as the first option to future mothers. In addition, the analysis of the cases in which, on the contrary, they would recommend birth by Caesarean section (23%) revealed that they objectively had births that had not been optimally managed and hence, the recommendation for careful, professional evaluation of the conditions of birth for each case. Reaching an optimal rate of Caesarean sections is an objective that can be achieved through correct information, health education and the correct management of the cases. Full article

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7 pages, 178 KiB

Open AccessArticle

The Social and the Psychological Impact of Endometriosis on the Romanian Urban Population

by Iulia Baciu, Alecsandra Irimie-Ana, Anca Maria Panaitescu, Gheorghe Peltecu, Corina Gica and Nicolae Gica

J. Mind Med. Sci. 2021, 8(1), 120-126; https://doi.org/10.22543/7674.81.P120126 - 8 Apr 2021

Cited by 2 | Viewed by 133

Abstract

Objectives. Our study assesses the social and psychological impact of the symptoms of endometriosis. Materials and methods. This crosssectional study was conducted from January 2014 to January 2016. The research involved two groups. The study instrument, the EHP-5 questionnaire, was completed by the [...] Read more.

Objectives. Our study assesses the social and psychological impact of the symptoms of endometriosis. Materials and methods. This crosssectional study was conducted from January 2014 to January 2016. The research involved two groups. The study instrument, the EHP-5 questionnaire, was completed by the respondents on the admission date or on the routine gynecological visit day. Results. Endometriosis has a negative social and psychological impact on women’s life, the most affected areas being work, fertility and sexual activity. Moreover, pain and the negative perception of self-image are major sources of distress. Conclusion. The symptoms and effects of endometriosis, especially chronic pelvic pain, mood changes and infertility, are significant negative factors in women’s life. The authors further conclude that the EHP-5 questionnaire can be more widely used to help select women who may need special attention in terms of their quality of life, thus helping gynecologists refer affected women to a health care professional. Full article

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12 pages, 344 KiB

Open AccessArticle

Representations and Narratives of F to M Gender Dysphoric Subjects: Self, Body and Psycho-Traumatology in Comparison with M to F Transsexualism

by Emanuele Maria Merlo

J. Mind Med. Sci. 2021, 8(1), 108-119; https://doi.org/10.22543/7674.81.P108119 - 8 Apr 2021

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Abstract

The present study was aimed at extending the method previously used with M to F gender dysphoric patients, to F to M individuals. In particular, the aim of the study was to highlight global and particular representations of the subjects. The study involved [...] Read more.

The present study was aimed at extending the method previously used with M to F gender dysphoric patients, to F to M individuals. In particular, the aim of the study was to highlight global and particular representations of the subjects. The study involved 10 gender dysphoric subjects in F to M transition, aged between 18 to 26 years old. Rorschach and the Thematic Apperception Test were administered with particular attention to the detection of psycho-traumatic indexes. The data reached through the extension of the method to F to M subjects revealed a continuity between the two groups. Referring to Self-representation, the subjects produced mainly objectual responses, indicative of a global representation affected by the current physical condition. In terms of Body representation, the subjects provided answers demonstrating the presence of partiality and fragmentation, indicative of a body representation supporting the term dysphoria. Approximately 30% of the subjects' responses indicated the presence of consistent psycho-traumatology. In comparative terms, F to M subjects provided quantitatively and quantitatively similar answers to M to F subjects, with a greater number of fragmentary responses and a lower presence of psycho-traumatic indexes. Full article

8 pages, 278 KiB

Open AccessArticle

The Relationship Between Spiritual Health and Social Trust Among Students

by Farzin Rezaei, Hero Khwrshid Hassan, Arezoo Fallahi, Reza Ghanei Gheshlagh, Shahram Sadeghi, Parisa Fallahi and Babak Nemat

J. Mind Med. Sci. 2021, 8(1), 100-107; https://doi.org/10.22543/7674.81.P100107 - 8 Apr 2021

Cited by 3 | Viewed by 79

Abstract

Social trust and spiritual health play an important role in social communication. The aim of this study was to determine the relationship between spiritual health and social trust among Iranian students. This cross-sectional study was conducted in the city of Sanandaj, in the [...] Read more.

Social trust and spiritual health play an important role in social communication. The aim of this study was to determine the relationship between spiritual health and social trust among Iranian students. This cross-sectional study was conducted in the city of Sanandaj, in the West of Iran, in 2018. 686 students from 5 universities were included in the study through simple random sampling. The data were collected using established, reliable instruments for the assessment of social trust and spiritual health. Logistic regression models were applied to assess the association between social trust and spiritual health. We reported estimated logits and Odds Ratios (OR) with corresponding 95% confidence intervals (95% CI). The students with a literate father had substantially higher odds of social trust (OR = 1.98, 95% CI = 1.19–3.28, p < 0.01). Also, similar findings were obtained for students with a literate mother compared to those with an illiterate mother (OR = 2.09, 95% CI = 1.33–3.28, p < 0.01). The odds of social trust also increased with the father’s employment status (OR = 13.06, 95% CI = 4.16–41, p < 0.01). The odds of social trust increased with religious health (OR = 1.05, 95% CI = 1.03–1.08, p < 0.01). It is essential to increase spiritual health and the parents’ literacy to promote social trust among the students. Full article

6 pages, 192 KiB

Open AccessArticle

A Comprehensive Analysis of Postpartum Depression and Delivery Characteristics: A Cross-Sectional Study

by Navdar Dogus Uzun, Mustafa Tekin and Fulya Uzun

J. Mind Med. Sci. 2021, 8(1), 94-99; https://doi.org/10.22543/7674.81.P9499 - 8 Apr 2021

Cited by 1 | Viewed by 97

Abstract

Objective: We attempted to identify risk factors for postpartum depression (PPD) by evaluating individuals in terms of their birth patterns, as well as other characteristics, including income level, smoking habits, number of children, age, and history of antidepressants. Methods and results: Participants completed [...] Read more.

Objective: We attempted to identify risk factors for postpartum depression (PPD) by evaluating individuals in terms of their birth patterns, as well as other characteristics, including income level, smoking habits, number of children, age, and history of antidepressants. Methods and results: Participants completed a questionnaire consisting of three sections: demographic characteristics, delivery characteristics, and Edinburgh Postpartum Depression Scale. Participants with a depression medical history had a higher depression level during the postpartum. There were significant correlations between postpartum depression, the husband’s working status, the desire fo r the pregnancy, and the patient’s depression medical history. PPD levels did not differ for other birth-related variables. Conclusions: It is important to use appropriate screening tools to identify mothers with PPD in the community. It is also important to instruct mothers about how to care for both their babies and themselves. For this reason, the mother should be monitored for the first six months postpartum, and social—familial support should also be monitored. Full article

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8 pages, 228 KiB

Open AccessArticle

Alexithymia and Physical Outcomes in Psychosomatic Subjects: A Cross-Sectional Study

by Liam Alexander MacKenzie Myles and Emanuele Maria Merlo

J. Mind Med. Sci. 2021, 8(1), 86-93; https://doi.org/10.22543/7674.81.P8693 - 8 Apr 2021

Cited by 33 | Viewed by 135

Abstract

Backgrounds. Alexithymia is a relevant phenomenon, occurring transversally to healthy subjects and individuals affected by several conditions. Its role is considerable, according to current state of the art several conditions emerged as influenced, maintained and worsened by alexithymic structures and figures. The present [...] Read more.

Backgrounds. Alexithymia is a relevant phenomenon, occurring transversally to healthy subjects and individuals affected by several conditions. Its role is considerable, according to current state of the art several conditions emerged as influenced, maintained and worsened by alexithymic structures and figures. The present study was aimed at highlighting the existing relations, the differences and the directions assumed by alexithymic factors and health status in patients affected by psychosomatic conditions. Methods. The sample consisted of 150 participants, 42 males (28.0%) and 108 females (72.0%), aged 26 to 78 years old with a mean of 42.24 years old (SD = 12.39). Subjects were previously assessed through DCPR-SI, in order to identify psychosomatic issues. The study evaluated measures related to alexithymia (Tas-20) and health status (SF-36), and considered demographic characteristics such as age, gender, and education. Results and Conclusions. The analyses demonstrated a number of significant relationships between alexithymia, psychological outcomes, and physical outcomes, including psychosomatic disorders. In addition, sex differences were found in gastrointestinal outcomes, as well as outcomes related to energy/fatigue and physical functioning. The study of alexithymia may provide a fruitful approach in understanding various issues related to pathology and general health. Further studies are needed to expand the understanding of alexithymia to other groups and health-related outcomes. Full article

10 pages, 272 KiB

Open AccessArticle

Support for Family Members Who Are Caregivers to Relatives with Acquired Brain Injury

by Janet Walker, Lourens Schlebusch and Bernhard Gaede

J. Mind Med. Sci. 2021, 8(1), 76-85; https://doi.org/10.22543/7674.81.P7685 - 8 Apr 2021

Cited by 4 | Viewed by 96

Abstract

Objectives. Family members caring for a patient with acquired brain injury (ABI) are coping with inordinate levels of stress partially due to their lack of understanding of the neuropsychological effects of acquired brain injury in the patient. The objective of this research [...] Read more.

Objectives. Family members caring for a patient with acquired brain injury (ABI) are coping with inordinate levels of stress partially due to their lack of understanding of the neuropsychological effects of acquired brain injury in the patient. The objective of this research is to show that as the caregivers’ stress levels increase, there is an increase in suicidal ideation. This highlights the causal relationship between unhealthy stress and reduced psychological well-being in these caregivers. In addition, qualitative research evidence regarding the caregivers’ views of their main sources of stress are presented. Methods. The participants were a random sample of 80 family caregivers of patients with acquired brain injury, out of whom 72.5% (58) are primary caregivers and 27.5% (22) are secondary caregivers. A mixed methodology was utilized. It comprised cross-sectional descriptive and phenomenological approaches. Quantitative data were obtained from two standardized measures: The Stress Symptom Checklist (SSCL) and item 9 of the Beck Depression Inventory. The qualitative data were derived from self-report procedures that were part of a structured questionnaire administered individually during the interviews. Results. The Kruskal-Wallis test with a significance level of p = 0.05 was used to compare the stress and suicidal ideation scores, which revealed that increasing levels of stress led to increased suicidality. The analysis of the qualitative data revealed five themes which were identified as the triggers of the caregivers’ profound stress. Most caregivers felt that it was predominantly the patient’s neuropsychological deficits, such as emotions and/or moods, cognitive ability, behavior and personality, executive function, and social factors that caused them profound stress. Conclusions. Support and education are needed to help family caregivers understand the neuropsychological impact of acquired brain injury on the patient. Once caregivers have an improved understanding and receive better support from healthcare providers, they should experience less stress and be better prepared to provide the appropriate support to patients with acquired brain injury. Full article

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5 pages, 165 KiB

Open AccessReview

Modern Approaches for Antiandrogen-Resistant Prostate Cancer Therapy

by Felix Voinea, Laura Mazilu, Ioan Sergiu Micu, Adrian Paul Suceveanu, Madalina Iliescu, Andrada Dumitru, Vlad Denis Constantin, Ioana Paunica and Andra Iulia Suceveanu

J. Mind Med. Sci. 2021, 8(1), 71-75; https://doi.org/10.22543/7674.81.P7175 - 8 Apr 2021

Cited by 2 | Viewed by 86

Abstract

Prostate cancer represents the leading malignant tumor in men over 50 years of age with 400,000 new cases being diagnosed yearly in Europe. Even if the incidence rate is higher than the mortality rate, still there is an increasing trend when speaking of [...] Read more.

Prostate cancer represents the leading malignant tumor in men over 50 years of age with 400,000 new cases being diagnosed yearly in Europe. Even if the incidence rate is higher than the mortality rate, still there is an increasing trend when speaking of its mortality. The increasing incidence of the metabolic syndrome, the unhealthy lifestyle, the high lipid and Calcium intake, the high spread of infections with Human Papilloma Virus, Human Herpes Virus, the excess of androgen consumption and the longer life expectancy, are few of the main causes of prostate cancer increasing incidence. The new systemic therapies such as immunotherapy with Checkpoint Inhibitors or Poly, ADP-Ribose Polymerase inhibitors and local experimental procedures addressing tumor destruction, such as High- Intensity Focused Ultrasound, the Cryo and Focal Laser Ablation, provide good outcomes and become new promising tools for prostate cancer therapy. Physicians consider these methods worth using; the efficacy of some specific categories of patients being arguments for their use in the current protocols even though solid data regarding the improvement of global mortality rates are not yet published. The current article focuses on the newest systemic and local experimental treatment tools highlighting their benefits, especially for hormone-resistant prostate cancer. Full article

11 pages, 397 KiB

Open AccessReview

Non-Dental Oral Cavity Findings in Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis

by Madalina-Gabriela Indre, Darius Sampelean, Vlad Taru, Angela Cozma, Dorel Sampelean, Mircea Vasile Milaciu and Olga Hilda Orasan

J. Mind Med. Sci. 2021, 8(1), 60-70; https://doi.org/10.22543/7674.81.P6070 - 8 Apr 2021

Cited by 2 | Viewed by 90

Abstract

Gastroesophageal reflux disease (GERD) is known as the most prevalent gastrointestinal disorder in the United States, leading to substantial morbidity, although associated mortality is rare. Based on the appearance of esophageal mucosa on upper endoscopy, GERD is divided into erosive esophagitis (ERD) and [...] Read more.

Gastroesophageal reflux disease (GERD) is known as the most prevalent gastrointestinal disorder in the United States, leading to substantial morbidity, although associated mortality is rare. Based on the appearance of esophageal mucosa on upper endoscopy, GERD is divided into erosive esophagitis (ERD) and nonerosive reflux disease (NERD). Heartburn and acid regurgitation are the typical symptoms of the disease, although some patients may present atypical manifestations such as epigastric pain, nausea, asthma, chronic cough, pharyngitis, laryngitis, sleep disturbances, otitis, and sinusitis. Other signs, such as oral mucosal lesions may result from GERD by direct acid or acidic vapor contact in the oral cavity. Oral manifestations such as tooth erosion, periodontitis, gingivitis, palatal erythema, ulceration, glossitis, oral acid burning sensation, halitosis, xerostomia have recently been reported in GERD patients. A considerable percentage of the patients are affected by oral manifestations before the onset of gastrointestinal symptoms, although in most cases the gastrointestinal signs and symptoms dominate the clinical picture. The injured oral mucosa negatively impacts the quality of life, especially functional limitation, physical inability and psychological disabilities, thus leading to social isolation. There is plenty of non-standardized information on the oral mucosal changes in GERD. In this context, we aimed at synthesizing and analyzing the current available evidence on non-dental oral cavity lesions and complaints that are present in patients diagnosed with GERD. Full article

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7 pages, 247 KiB

Open AccessReview

The Analysis of Risk Factors Associated with Women’s Urinary Incontinence; Literature Review

by Oana Denisa Balalau, Octavian Gabriel Olaru, Nicolae Bacalbasa, Stana Paunica, Daniela Gabriela Balan and Anca Daniela Stanescu

J. Mind Med. Sci. 2021, 8(1), 53-59; https://doi.org/10.22543/7674.81.P5359 - 8 Apr 2021

Cited by 4 | Viewed by 163

Abstract

Urinary incontinence (UI) is a common condition among women. Approximately 50% of them had an involuntary loss of urine at least once in their lifetime. It can be present during sexual activity, contributing to sexual dysfunction and often associated with anxiety or even [...] Read more.

Urinary incontinence (UI) is a common condition among women. Approximately 50% of them had an involuntary loss of urine at least once in their lifetime. It can be present during sexual activity, contributing to sexual dysfunction and often associated with anxiety or even depression, thus having a negative impact on the quality of life. The incidence of UI is related to the existence of predisposing factors. The best known are: age, weight, family history, race/ ethnicity, number of pregnancies and mode of birth, history of genitourinary interventions and factors related to ordinary habits: smoking, caffeine consumption, oral contraceptives. Studies on middle-aged women have revealed that BMI, parity, age, hysterectomy, smoking, race/ethnicity and diabetes are factors often associated with urinary incontinence. Future studies are needed to further explore the risk factors for urinary incontinence. Full article

9 pages, 182 KiB

Open AccessReview

A Mini-Review Regarding the Carcinogenesis and Morphology of Serous Tumors of the Ovary, Fallopian Tube and Peritoneum

by Tiberiu-Augustin Georgescu, Roxana Bohiltea, Octavian Munteanu, Corina Grigoriu, Ioana Paunica and Maria Sajin

J. Mind Med. Sci. 2021, 8(1), 44-52; https://doi.org/10.22543/7674.81.P4452 - 8 Apr 2021

Cited by 6 | Viewed by 75

Abstract

Similar to the already well-recognized adenoma-carcinoma sequence in colorectal cancer pathogenesis, it has been believed for many decades that the progression of ovarian epithelial tumors occurs from benign serous cystadenomas to borderline tumors, to well-differentiated carcinomas, and ultimately, to poorly differentiated carcinomas. However, [...] Read more.

Similar to the already well-recognized adenoma-carcinoma sequence in colorectal cancer pathogenesis, it has been believed for many decades that the progression of ovarian epithelial tumors occurs from benign serous cystadenomas to borderline tumors, to well-differentiated carcinomas, and ultimately, to poorly differentiated carcinomas. However, it is currently accepted that low-grade serous carcinoma (LGSC) and high-grade serous carcinoma (HGSC) are fundamentally different tumor types and, consequently, different diseases. In fact, whereas the benign-borderline-malignant sequence seems to apply quite well to low-grade serous carcinoma, the sequence of genetic alterations in high-grade serous carcinoma is substantially different. In this mini-review, we included the current consensus regarding the morphological and etiopathogenic results regarding serous tumors of the ovary, fallopian tube and peritoneum. It also briefly describes the history of benign, borderline and malignant serous tumors, discussing multiple types of dichotomies in serous carcinomas of the female genital tract and summarizing the current molecular classification. Full article

10 pages, 245 KiB

Open AccessReview

Biochemical and Echocardiographic Markers for the Early Detection of Cardiotoxicity Under Monoclonal Antibodies Therapy

by Ionela-Emilia Popovici, Angela Cozma, Olga Hilda Orasan, George Ciulei, Ana Maria Poenar, Cristina Buchman, Simina Tarmure, Sorina Secara, Adela Sitar-Taut, Teodora Alexescu, Andrada Lazar, Vasile Negrean and Lucia Maria Procopciuc

J. Mind Med. Sci. 2021, 8(1), 34-43; https://doi.org/10.22543/7674.81.P3443 - 8 Apr 2021

Cited by 1 | Viewed by 86

Abstract

The progress made over the past years in the field of cancer therapy has led to a significant decrease in cancer mortality, but these therapies have many adverse effects, cardiovascular effects being among the most frequent ones. For increasing lifelong expectancy of surviving [...] Read more.

The progress made over the past years in the field of cancer therapy has led to a significant decrease in cancer mortality, but these therapies have many adverse effects, cardiovascular effects being among the most frequent ones. For increasing lifelong expectancy of surviving cancer patients, cardiac monitoring represents an important task. Current studies and practice recommend echocardiography using strain analysis for monitoring the cardio toxic effects of cancer therapy. The potential of combining imaging techniques with biomarkers for the early detection and diagnosis seems a promising path for future research. Full article

7 pages, 219 KiB

Open AccessReview

Periodontitis as a Potential Risk Factor for Premature Delivery

by Ana Turcu-Duminică, Anca Silvia Dumitriu, Stana Paunica, Corina Gică, Radu Botezatu, Nicolae Gică, Gheorghe Peltecu and Anca Maria Panaitescu

J. Mind Med. Sci. 2021, 8(1), 27-33; https://doi.org/10.22543/7674.81.P2733 - 8 Apr 2021

Cited by 1 | Viewed by 87

Abstract

Pregnancy is a particular period of time for a woman, so that it is important to accurately determine the impact of adjacent pathologies on the natural evolution of the nine months of pregnancy. Although there is still much to debate on the association [...] Read more.

Pregnancy is a particular period of time for a woman, so that it is important to accurately determine the impact of adjacent pathologies on the natural evolution of the nine months of pregnancy. Although there is still much to debate on the association between periodontal disease and pregnancy, the conclusion seems to remain the same: untreated periodontal pathology in pregnancy could have adverse consequences such as premature birth or low birth weight fetuses. Periodontopathies are introduced as risk factors, the novelty of the subject being the association between untreated periodontal pathology and the evolution of pregnancy. The affected periodontal tissue has the potential of releasing microorganisms that could colonize the placenta, ultimately having adverse consequences on the evolution of pregnancy, consequences such as premature birth or inadequate birth weight. The purpose of this review is to assess the association between periodontal disease and the negative consequences on pregnancy. Using databases such as PubMed, more than 1500 articles were screened, including systematic reviews, case-control studies and prospective cohort studies assessing the association between periodontitis and pregnancy. Only 54 from the abovementioned papers were included in the final review. Full article

10 pages, 258 KiB

Open AccessReview

Linking the Brain and Bone Through Fat

by Elisabeta Malinici, Anca Sirbu, Miruna Popa and Simona Fica

J. Mind Med. Sci. 2021, 8(1), 17-26; https://doi.org/10.22543/7674.81.P1726 - 8 Apr 2021

Cited by 4 | Viewed by 82

Abstract

Over the past years, bone and adipose tissue have gained interest from researchers in the light of their secretory profiles, being able to produce active molecules, with the final effect of regulating energy homeostasis. Both adipocytes and osteoblasts originate in the pluripotent mesenchymal [...] Read more.

Over the past years, bone and adipose tissue have gained interest from researchers in the light of their secretory profiles, being able to produce active molecules, with the final effect of regulating energy homeostasis. Both adipocytes and osteoblasts originate in the pluripotent mesenchymal stem cell and this common origin has been proposed as the core of the fat-bone relationship. The central nervous system might be the third player in this association, capable of integrating signals. Numerous adipose tissue secreted factors that influence energy homeostasis and bone have been described: leptin, adiponectin, lipocalin 2, and inflammatory cytokines (e.g. IL-1, IL-6 and TNF-α). Similarly, osteocalcin, the most abundant bone protein, has been shown to elicit numerous central and peripheral endocrine functions. In this paper, we provide a review of the current literature regarding the bone-adipose tissue-central nervous system axis and a brief description of the several underlying molecular mechanisms. Full article

12 pages, 291 KiB

Open AccessReview

Alcohol Consumption and Cognitive Aging: Can It Be Beneficial?

by Margarita Velikova, Bistra Galunska, Raya Dimitrova and Zlatislav Stoyanov

J. Mind Med. Sci. 2021, 8(1), 5-16; https://doi.org/10.22543/7674.81.P516 - 8 Apr 2021

Cited by 6 | Viewed by 130

Abstract

We present a literature review which summarizes the data supporting one of the alternative perspectives on the effect of alcohol consumption on cognitive aging—the possible positive effect of low to moderate drinking. Some of the main theories about aging, the mechanisms of brain [...] Read more.

We present a literature review which summarizes the data supporting one of the alternative perspectives on the effect of alcohol consumption on cognitive aging—the possible positive effect of low to moderate drinking. Some of the main theories about aging, the mechanisms of brain aging, and the pathogenesis of cognitive decline and dementia are briefly described. In this context, the putative mechanisms of the protective action of non-alcoholic components in alcoholic beverages or low doses of ethanol against oxidative stress, inflammation, mitochondrial dysfunction, brain insulin resistance, and production of amyloid-β peptides are presented. The review article does not favor the data selected and highlighted, but it aims at inspiring more interest and further research on the topic. Full article

4 pages, 143 KiB

Open AccessReview

Modes of Birth and Their Impact on the Psychological and Physical Health of Women

by Myriam Natascha Wieser, Kleanthi Gourounti and Antigoni Sarantaki

J. Mind Med. Sci. 2021, 8(1), 1-4; https://doi.org/10.22543/7674.81.P14 - 8 Apr 2021

Cited by 5 | Viewed by 82

Abstract

Objective. The aim of this review was to evaluate the literature concerning modes of birth and their impact on the psychological and physical health of women. Methods. A search was conducted in PubMed Central and Scopus to identify relevant studies in the literature. [...] Read more.

Objective. The aim of this review was to evaluate the literature concerning modes of birth and their impact on the psychological and physical health of women. Methods. A search was conducted in PubMed Central and Scopus to identify relevant studies in the literature. The searching phrases were “mode of birth” AND “maternal health”. No date restriction was applied. The languages were restricted to English, German, and Greek. Results. Women giving birth through assisted vaginal births, especially by means of forceps, had a higher risk of dealing with different health problems in the postpartum period. Caesarean sections are not able to prevent long-term problems related to incontinence or sexuality. Conclusions. The mode of birth has an impact on the health of women postpartum and in some cases in the long term. Therefore, the mode of birth should be chosen deliberately for each individual woman, while having in mind the possible risks of the different modes of birth. Additionally, further research is needed to highlight the prevalence of postpartum morbidity. Full article

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J. Mind Med. Sci., Volume 8, Issue 1 (April 2021) – 21 articles

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