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Allergies, Volume 5, Issue 4

December 2025 - 13 articles

Cover Story: In this cover image, the skin microbiome is portrayed as both a trigger and a shield for itch. On the left, bacteria, fungi, and viruses release proteases, pore-forming peptides, and toxins that activate PARs, TRP channels, and MRGPRs on sensory nerves, leading to barrier disruption, type 2 inflammation, and the itch–scratch cycle. On the right, selected commensals such as Malassezia, Roseomonas mucosa, and Staphylococcus hominis support epidermal lipids, tight junctions, and antimicrobial peptides, thereby restoring barrier function and reducing neuro-immune activation. The lower panel highlights how integrating microbiome-directed strategies with IL-31 or IL-4/13 blockade may transform pruritus care—shifting from pathogen eradication alone to ecosystem-aware precision therapies. View this paper

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Review

1,928 Views

11 Pages

Are Rhinitis and Asthma Just One Disease Affecting Different Parts of the Respiratory Tract?

Victor Alexandru,
Felicia Manole and
Alexia Manole

Allergies2025, 5(4), 34;https://doi.org/10.3390/allergies5040034

3 October 2025

Both allergic rhinitis and chronic rhinosinusitis with or without nasal polyps have important factors in common with asthma. They are often present simultaneously, they have similar pathogenesis processes, and they have synergistic effects on the cli...

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Protocol

3,045 Views

13 Pages

Effect of Photobiomodulation Therapy in an Experimental Model of Chronic Obstructive Pulmonary Disease: A Dosimetric Study

Cintia Estefano Alves,
Tawany Gonçalves Santos,
Luana Beatriz Vitoretti,
Cinthya Cosme Gutierrez Duran,
Stella Zamuner,
Rodrigo Labat,
José Antonio Silva,
Maria Cristina Chavantes,
Flavio Aimbire and
Renata Kelly da Palma
+ 1 author

Allergies2025, 5(4), 33;https://doi.org/10.3390/allergies5040033

26 September 2025

This study aimed to evaluate the effects of different dosimetric parameters of photobiomodulation therapy (PBMT) in an experimental model of chronic obstructive pulmonary disease (COPD). C57BL/6 mice were assigned to the following groups: Baseline, C...

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Review

1 Citations

1,478 Views

17 Pages

Pruritus in Autoimmune Demyelinating Diseases of the Central Nervous System: A Review

Christian Messina and
Mariateresa Zuccarello

Allergies2025, 5(4), 32;https://doi.org/10.3390/allergies5040032

23 September 2025

Pruritus (itching) is an underrecognized but often debilitating symptom in patients with central nervous system (CNS) demyelinating diseases, including multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). It is often considered...

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