Skin Barrier Function and Immune Mediators as Key Therapeutic Targets of Main Inflammatory Diseases

Topic Information

Dear Colleagues,

Inflammation usually refers to the defensive response of living tissue to inflammatory factors and local damage. The skin, as one of the largest immune organs, is involved in many inflammatory conditions, such as psoriasis, atopic dermatitis, acne, bullous diseases, and hidradenitis suppurativa. These conditions are closely related to severe systemic complications, such as arteriosclerosis, cardiovascular disease, abnormal fat metabolism, nephrosclerosis, and systemic amyloidosis. Timely diagnosis and precision medicine are particularly important for patients, and thus, continued research efforts are required. The following Topic encourages contributors to explore the biological and clinical aspects of the complex interplay between the skin barrier and inflammation, which may act as pivotal actors in the pathogenesis of many diseases. We hope to shed new light on this exciting and insightful field of research from a multidisciplinary perspective. A better understanding of the corresponding pathogenetic mechanisms can aid in the development of new therapeutic agents aimed at eradicating these diseases. We welcome original research papers in addition to critiques and opinion papers. Special clinical cases may also be included. As a part of this Topic, the readership will find accounts of relevant research carried out by numerous healthcare professionals and researchers with extensive knowledge in basic and clinical settings, with the aim of translating basic research into clinical practice.

Dr. Marco Manfredini
Dr. Carlo Pincelli
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Cells cells	5.2	10.5	2012	16 Days	CHF 2700	Submit
Immuno immuno	2.5	3.7	2021	31.6 Days	CHF 1200	Submit
International Journal of Molecular Sciences ijms	4.9	9.0	2000	20.5 Days	CHF 2900	Submit
Journal of Clinical Medicine jcm	2.9	5.2	2012	17.7 Days	CHF 2600	Submit
Allergies allergies	-	-	2021	34.8 Days	CHF 1000	Submit
Dermato dermato	-	-	2021	25.1 Days	CHF 1000	Submit

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Published Papers (1 paper)

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All Cells Immuno IJMS JCM Allergies Dermato

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22 pages, 1794 KiB  

Open AccessReview

Chronic Rhinosinusitis with Nasal Polyps: Window of Immunologic Responses and Horizon of Biological Therapies

by Simin Farokhi, Seyed Mehdi Tabaie, Arshia Fakouri, Shirin Manshouri, Nikoo Emtiazi, Ayda Sanaei, Mohammad Mahjoor, Amir Mohammad Akbari, Ali Daneshvar and Farhad Seif

Immuno 2025, 5(3), 26; https://doi.org/10.3390/immuno5030026 - 11 Jul 2025

Viewed by 430

Abstract

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifaceted inflammatory disorder characterized by distinct immunopathogenic entities, including type 2 inflammation mediated by cytokines such as interleukin-4 (IL-4), IL-5, and IL-13. These cytokines contribute to eosinophilic inflammation, epithelial barrier dysfunction, and mucus overproduction, resulting [...] Read more.

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifaceted inflammatory disorder characterized by distinct immunopathogenic entities, including type 2 inflammation mediated by cytokines such as interleukin-4 (IL-4), IL-5, and IL-13. These cytokines contribute to eosinophilic inflammation, epithelial barrier dysfunction, and mucus overproduction, resulting in polyp formation. Advances in molecular understanding have resulted in the identification of CRSwNP endotypes, suggesting personalized treatment approaches. Conventional therapies, such as intranasal and systemic corticosteroids, provide symptom relief but are restricted by side effects and polyp recurrence, necessitating the development of novel targeted approaches. Biologic therapies represent a breakthrough in CRSwNP management. Monoclonal antibodies such as dupilumab, omalizumab, mepolizumab, and Benralizumab (IL-5 receptor alpha) target key mediators of type 2 inflammation, leading to substantial improvements in polyp size, symptom control, and quality of life. Additionally, emerging therapies like tezepelumab and brodalumab aim to address broader immune mechanisms, including type 1 and type 3 inflammation. These advancements enable tailored treatment approaches that optimize outcomes and reduce reliance on surgical interventions. Biomarker-driven research continues to refine CRSwNP classification and treatment efficacy, emphasizing precision medicine. Future efforts should focus on expanding the therapeutic landscape, investigating long-term impacts of biologics, and exploring their combinatory potential to improve disease control. This review discusses the role of innate and adaptive immunity in the pathogenesis of CRSwNP and suggests novel cytokine-targeted strategies for further considering personalized medicine in future therapeutic plans. Full article

(This article belongs to the Topic Skin Barrier Function and Immune Mediators as Key Therapeutic Targets of Main Inflammatory Diseases)

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