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Non-Coding RNA, Volume 5, Issue 3

2019 September - 5 articles

Cover Story: Long noncoding RNAs (lncRNAs) are emerging as fundamental players in gene regulation determining the outcomes of a plethora of cellular functions. Recent studies have identified a number of lncRNAs as critical regulators of T helper cell differentiation, activation, and function. As RNA targeting therapeutics are rapidly gaining attention, further characterising the mechanistic role of lncRNAs in CD4+ T cells is an exciting challenge which may unearth a wide range of novel candidate therapeutic targets for treatment of infectious diseases and chronic immunopathologies. View this paper.

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Articles (5)

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Feature Paper
Article

12 Citations

5,980 Views

12 Pages

Long Non-Coding RNAs as Molecular Signatures for Canine B-Cell Lymphoma Characterization

Luciano Cascione,
Luca Giudice,
Serena Ferraresso,
Laura Marconato,
Diana Giannuzzi,
Sara Napoli,
Francesco Bertoni,
Rosalba Giugno and
Luca Aresu

Non-Coding RNA2019, 5(3), 47;https://doi.org/10.3390/ncrna5030047

19 September 2019

Background: Diffuse large B-cell lymphoma (DLBCL), marginal zone lymphoma (MZL) and follicular lymphoma (FL) are the most common B-cell lymphomas (BCL) in dogs. Recent investigations have demonstrated overlaps of these histotypes with the human count...

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Feature Paper
Review

13 Citations

5,678 Views

7 Pages

meiRNA, A Polyvalent Player in Fission Yeast Meiosis

Akira Yamashita

Non-Coding RNA2019, 5(3), 45;https://doi.org/10.3390/ncrna5030045

17 September 2019

A growing number of recent studies have revealed that non-coding RNAs play a wide variety of roles beyond expectation. A lot of non-coding RNAs have been shown to function by forming intracellular structures either in the nucleus or the cytoplasm. In...

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Feature Paper
Review

62 Citations

8,049 Views

22 Pages

The Growth-Arrest-Specific (GAS)-5 Long Non-Coding RNA: A Fascinating lncRNA Widely Expressed in Cancers

Anton Scott Goustin,
Pattaraporn Thepsuwan,
Mary Ann Kosir and
Leonard Lipovich

Non-Coding RNA2019, 5(3), 46;https://doi.org/10.3390/ncrna5030046

17 September 2019

Long non-coding RNA (lncRNA) genes encode non-messenger RNAs that lack open reading frames (ORFs) longer than 300 nucleotides, lack evolutionary conservation in their shorter ORFs, and do not belong to any classical non-coding RNA category. LncRNA ge...

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Article

24 Citations

6,691 Views

10 Pages

High Positive Correlations between ANRIL and p16-CDKN2A/p15-CDKN2B/p14-ARF Gene Cluster Overexpression in Multi-Tumor Types Suggest Deregulated Activation of an ANRIL–ARF Bidirectional Promoter

Kinan Drak Alsibai,
Sophie Vacher,
Didier Meseure,
Andre Nicolas,
Marick Lae,
Anne Schnitzler,
Walid Chemlali,
Jerome Cros,
Elisabeth Longchampt and
Ivan Bieche
+ 5 authors

Non-Coding RNA2019, 5(3), 44;https://doi.org/10.3390/ncrna5030044

21 August 2019

The CDKN2B-AS1 gene, also called ANRIL, is located at the human CDKN2A/B locus at 9p21.3 and transcribed by RNA polymerase II into a long non-coding RNA of 3834 bp. The CDKN2B-AS1 gene overlaps a critical region of 125 kb covering the CDKN2B gene. Th...

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Feature Paper
Review

23 Citations

6,744 Views

15 Pages

Long Non-Coding RNA Function in CD4⁺ T Cells: What We Know and What Next?

Katie A. West and
Dimitris Lagos

Non-Coding RNA2019, 5(3), 43;https://doi.org/10.3390/ncrna5030043

12 July 2019

The non-coding genome has previously been regarded as “junk” DNA; however, emerging evidence suggests that the non-coding genome accounts for some of the greater biological complexity observed in mammals. Research into long non-coding RNA...

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