Non-Coding RNA, Volume 5, Issue 4 (December 2019) – 7 articles
Cover Story (view full-size image): Liquid–liquid phase separation (LLPS) has emerged as a prominent mechanism governing the assembly of membraneless compartments in the nucleus. However, recent work reveals that some nuclear structures violate key predictions of LLPS. New experimental strategies, such as concentration dependence and diffusion dynamics, are necessary to distinguish LLPS from alternative mechanisms such as binding or bridging of nucleic acid scaffolds. The application of more rigorous criteria will enable us to identify the mechanism(s) that drive spatiotemporal organization of the nucleus and facilitate functional diversity among nuclear compartments. View this paper.
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