We find the comment on the article titled “Diabetic Foot and Fungal Infections: Etiology and Management from a Dermatologic Perspective” informative and wish to thank the authors for their added insight on this complex topic [1,2]. We agree that advanced glycation products formed within the diabetic patient may play a role directly in the development of onychomycosis. Understandably, there are multiple mechanisms at play for the increased risk of infection and complications in this patient population. The immunological pathways described are only one part of a much larger picture. Further knowledge on the interplay of these pathways, as well as any additional mechanisms, will be of the utmost importance to reducing the burden of onychomycosis in diabetic patients.
Conflicts of Interest
Authors Aditya K. Gupta, Vasiliki Economopoulos and Mesbah Talukder were employed by the company Mediprobe Research Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References
- Gupta, A.K.; Shemer, A.; Economopoulos, V.; Talukder, M. Diabetic Foot and Fungal Infections: Etiology and Management from a Dermatologic Perspective. J. Fungi 2024, 10, 577. [Google Scholar] [CrossRef] [Scilit] [PubMed]
- Cosio, T.; Valsecchi, I.; Gaziano, R.; Campione, E.; Botterel, F. Glycation of Nail Proteins as a Risk Factor for Onychomycosis. Comment on Gupta et al. Diabetic Foot and Fungal Infections: Etiology and Management from a Dermatologic Perspective. J. Fungi 2024, 10, 577. J. Fungi 2025, 11, 46. [Google Scholar] [CrossRef] [Scilit]
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