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Volume 13
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10.3390/jcdd13010010
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Time to Reperfusion Dictates Cardiac Function and Myocardial Strain in a 7-Tesla Magnetic Resonance Imaging Rat Model

by
Mako Ito
1,
Junpei Ueda
1,2,
Sei Yasuda
1,
Isamu Yabata
1,3,
Koji Itagaki
1,4,
Natsuo Banura
1,5 and
Shigeyoshi Saito
1,5,6,7,*
1
Department of Medical Physics and Engineering, Division of Health Sciences, The University of Osaka Graduate School of Medicine, Osaka 565-0871, Japan
2
Department of Radiological Sciences, Faculty of Health Sciences, Morinomiya University of Medical Sciences, Osaka 559-8611, Japan
3
Department of Radiology, The University of Osaka Hospital, Osaka 565-0871, Japan
4
Division of Clinical Radiology Service, Kyoto University Hospital, Kyoto 606-8507, Japan
5
Department of Advanced Medical Technologies, National Cerebral and Cardiovascular Research Center, Osaka 564-8565, Japan
6
Immunology Frontier Research Center, The University of Osaka, 3-1 Yamadaoka, Osaka 565-0871, Japan
7
World Premier International Research Center Initiative Premium Research Institute for Human Metaverse Medicine, The University of Osaka, 2-2 Yamadaoka, Osaka 565-0871, Japan
*
Author to whom correspondence should be addressed.
J. Cardiovasc. Dev. Dis. 2026, 13(1), 10; https://doi.org/10.3390/jcdd13010010
Submission received: 26 September 2025 / Revised: 16 December 2025 / Accepted: 17 December 2025 / Published: 22 December 2025
(This article belongs to the Section Basic and Translational Cardiovascular Research)
Versions Notes

Abstract

This study used a rat model of coronary artery reperfusion imaged with preclinical 7-tesla magnetic resonance imaging (7T-MRI) to evaluate cardiac function, myocardial deformation, and the impact of infarction-to-reperfusion time. Wistar rats were assigned to control (n = 6), 20 min infarction (n = 10), 30 min infarction (n = 6), and 40 min infarction (n = 6) groups. Myocardial infarction occurred in all infarction groups but not in controls. Imaging included short- and long-axis slices. Cardiac function was assessed using end-diastolic volume, end-systolic volume, and left-ventricular ejection fraction. Myocardial deformation was analyzed by circumferential strain, radial strain (RS), and longitudinal strain (LS, four-chamber and two-chamber) using feature tracking. The 30 and 40 min infarction groups showed significant reductions in cardiac function and strain compared to the controls. RS decreased significantly between the control and 20 min infarction groups (40.6 ± 4.7% and 34.0 ± 4.1%, p < 0.05). No significant LS difference was observed between 30 and 40 min. Consequently, RS detects early myocardial changes (20 min), whereas LS may reflect compensatory contractility in severe infarction. Preclinical 7T-MRI provides valuable insights into the impact of infarction duration on cardiac function and myocardial deformation.
Keywords: coronary artery reperfusion; Wistar rats; 7-tesla magnetic resonance imaging; strain; myocardial infarction; fibrosis coronary artery reperfusion; Wistar rats; 7-tesla magnetic resonance imaging; strain; myocardial infarction; fibrosis

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MDPI and ACS Style

Ito, M.; Ueda, J.; Yasuda, S.; Yabata, I.; Itagaki, K.; Banura, N.; Saito, S. Time to Reperfusion Dictates Cardiac Function and Myocardial Strain in a 7-Tesla Magnetic Resonance Imaging Rat Model. J. Cardiovasc. Dev. Dis. 2026, 13, 10. https://doi.org/10.3390/jcdd13010010

AMA Style

Ito M, Ueda J, Yasuda S, Yabata I, Itagaki K, Banura N, Saito S. Time to Reperfusion Dictates Cardiac Function and Myocardial Strain in a 7-Tesla Magnetic Resonance Imaging Rat Model. Journal of Cardiovascular Development and Disease. 2026; 13(1):10. https://doi.org/10.3390/jcdd13010010

Chicago/Turabian Style

Ito, Mako, Junpei Ueda, Sei Yasuda, Isamu Yabata, Koji Itagaki, Natsuo Banura, and Shigeyoshi Saito. 2026. "Time to Reperfusion Dictates Cardiac Function and Myocardial Strain in a 7-Tesla Magnetic Resonance Imaging Rat Model" Journal of Cardiovascular Development and Disease 13, no. 1: 10. https://doi.org/10.3390/jcdd13010010

APA Style

Ito, M., Ueda, J., Yasuda, S., Yabata, I., Itagaki, K., Banura, N., & Saito, S. (2026). Time to Reperfusion Dictates Cardiac Function and Myocardial Strain in a 7-Tesla Magnetic Resonance Imaging Rat Model. Journal of Cardiovascular Development and Disease, 13(1), 10. https://doi.org/10.3390/jcdd13010010

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