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Journal of Cardiovascular Development and Disease, Volume 12, Issue 2

February 2025 - 46 articles

Cover Story: Understanding hormonal and molecular changes from preterm to near-term is key to assessing how pregnancy complications affect fetal heart development and long-term cardiovascular risk. The correlation between cortisol and T3 in the near-term heart highlights the role of GC signalling in preparing for postnatal life. A decline in protein expression of GRs alongside markers of cardiac proliferative capacity suggests a shift toward cardiac maturation. Increased mitochondrial content/OXPHOS and changes in glucose transporters indicate a metabolic transition from glycolysis to more efficient OXPHOS. These data provide valuable insights into the mechanisms underlying cardiac adaptation, which may have implications for understanding developmental programming and the risk of CVD later in life. View this paper
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Articles (46)

  • Review
  • Open Access
3 Citations
3,519 Views
15 Pages

Stroke in Bangladesh: A Narrative Review of Epidemiology, Risk Factors and Acute Stroke Services

  • Mudasar Aziz,
  • Naznin Bipasha,
  • Udit Gupta,
  • Isabela V. P. Ramnarine,
  • Jessica Redgrave,
  • Ali N. Ali,
  • Arshad Majid and
  • Simon M. Bell

Introduction: Stroke is a major cause of mortality and disability worldwide. It is one of the foremost non-communicable diseases and the third leading cause of death in Bangladesh. Bangladesh is a developing country and as such, the prevalence, risk...

  • Article
  • Open Access
1,437 Views
12 Pages

Assessment of Paclitaxel Drug-Coated Balloon-Only Angioplasty for Stent Thrombosis: SPARTAN-ST Study

  • Ioannis Merinopoulos,
  • Bhalraam U,
  • Tharusha Gunawardena,
  • Natasha Corballis,
  • Rajkumar Natarajan,
  • Upul Wickramarachchi,
  • Clint Maart,
  • Sulfi Sreekumar,
  • Chris Sawh and
  • Johannes Reinhold
  • + 5 authors

Background: There are no data regarding the outcomes of patients with stent thrombosis (ST) being treated with drug-coated balloon (DCB) angioplasty. Our aim was to compare the outcomes of patients with ST treated with DCB vs. a drug eluting stent (D...

  • Article
  • Open Access
1 Citations
1,316 Views
15 Pages

Predictors of Visceral Infectious Aneurysms in Patients with Infective Endocarditis and Systemic Embolization

  • Monique Boukobza,
  • Emila Ilic-Habensus,
  • Xavier Duval and
  • Jean-Pierre Laissy

Background: To study whether infective endocarditis patients (IE-patients) with visceral embolic events (VEEs) at admission are at greater risk of developing visceral infectious aneurysms (VIAs) in left-sided infective endocarditis (LSIE) patients. M...

  • Article
  • Open Access
1 Citations
1,390 Views
17 Pages

To enhance the differentiation and maturation of cardiomyocytes derived from human induced pluripotent stem cells, we developed a bioreactor system that simultaneously imposes biophysical and biochemical stimuli on these committed cardiomyocytes. The...

  • Article
  • Open Access
1 Citations
1,488 Views
11 Pages

Outcomes of K-Clip Implantation for Functional Tricuspid Regurgitation Accompanied with Persistent Atrial Fibrillation

  • Da-Wei Lin,
  • Ling-Wei Zou,
  • Jia-Xin Miao,
  • Jia-Ning Fan,
  • Min-Fang Meng,
  • Yi-Ming Qi,
  • Zhi Zhan,
  • Wen-Zhi Pan,
  • Da-Xin Zhou and
  • Xiao-Chun Zhang
  • + 1 author

Background: Atrial fibrillation (AF) has been identified as a risk factor for functional tricuspid regurgitation (FTR) in the absence of other known etiologies, although limited interventional options are available. K-Clip™, a novel transcathet...

  • Review
  • Open Access
4 Citations
1,947 Views
10 Pages

Myocardial bridging (MB), a congenital variant where a coronary artery segment is tunneled within the myocardium, is increasingly recognized as a contributor to coronary endothelial and vasomotor dysfunction. Beyond the hallmark systolic compression...

  • Article
  • Open Access
1,144 Views
16 Pages

Background: Quantitative evaluation of myocardial function traditionally relies on parameters such as ejection fraction and strain. Strain, reflecting the relative change in the length of a myocardial segment over the cardiac cycle, has been extensiv...

  • Article
  • Open Access
1 Citations
1,336 Views
12 Pages

Atrial Fibrillation Prediction Model Following Aortic Valve Replacement Surgery

  • Nora Knez,
  • Tomislav Kopjar,
  • Tomislav Tokic and
  • Hrvoje Gasparovic

(1) Background: Postoperative atrial fibrillation (POAF) is the most common complication following cardiac surgery. It leads to increased perioperative morbidity and costs. Our study aimed to determine the incidence of new-onset POAF in patients unde...

  • Review
  • Open Access
1 Citations
3,199 Views
18 Pages

Vulnerable coronary atherosclerotic plaque involves a dynamic pathophysiologic process within and surrounding an atheromatous plaque in coronary artery intima. The process drastically increases the risk of plaque rupture and is clinically responsible...

  • Article
  • Open Access
1,708 Views
10 Pages

Impact of Heart Failure Team on Inpatient Rapid Sequencing of Heart Failure Therapy

  • Zhongrui Zhou,
  • Khalid Kardas,
  • Ying Xuan Gue,
  • Ali Najm,
  • Anas Tirawi,
  • Rachel Goode,
  • Robert Frodsham,
  • Rory Kavanagh,
  • Archana Rao and
  • Rebecca Dobson
  • + 2 authors

The management of heart failure (HF) has undergone a paradigm shift from conventional stepwise methods of initiation and the up-titration of HF therapy towards an early, more intensive initiation of pharmacotherapy to improve the prognosis. The aim o...

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J. Cardiovasc. Dev. Dis. - ISSN 2308-3425