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Journal of Cardiovascular Development and Disease, Volume 12, Issue 2

February 2025 - 46 articles

Cover Story: Understanding hormonal and molecular changes from preterm to near-term is key to assessing how pregnancy complications affect fetal heart development and long-term cardiovascular risk. The correlation between cortisol and T3 in the near-term heart highlights the role of GC signalling in preparing for postnatal life. A decline in protein expression of GRs alongside markers of cardiac proliferative capacity suggests a shift toward cardiac maturation. Increased mitochondrial content/OXPHOS and changes in glucose transporters indicate a metabolic transition from glycolysis to more efficient OXPHOS. These data provide valuable insights into the mechanisms underlying cardiac adaptation, which may have implications for understanding developmental programming and the risk of CVD later in life. View this paper
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Articles (46)

  • Article
  • Open Access
3 Citations
1,296 Views
11 Pages

Blood cell-derived indices are potential predictors of clinical outcomes in coronary artery disease. This study assessed the prognostic value of the pan-immune-inflammatory value (PIV) for predicting 1-year major adverse cardiovascular events (MACEs)...

  • Review
  • Open Access
2 Citations
1,886 Views
14 Pages

Invasive Physiological Assessment of Lower Limb Peripheral Arterial Disease: A Narrative Review

  • Sarosh Khan,
  • Samer Fawaz,
  • Uzma Sajjad,
  • Christopher Cook,
  • Grigoris V. Karamasis,
  • John Davies,
  • Ali Kordzadeh,
  • Elafra Nour,
  • Alun H. Davies and
  • Ankur Thapar
  • + 1 author

Peripheral arterial disease (PAD) affects over 236 million people globally, with endovascular treatment as the predominant mode of revascularization. While pre-procedural lesion assessment typically relies on non-invasive Doppler measurement, invasiv...

  • Article
  • Open Access
1 Citations
990 Views
10 Pages

Beyond Survival: Assessing Quality of Life, Activity Level, and Ethnic Diversity in Aortic Dissection Survivors

  • Nora Bacour,
  • Olivia van Erp,
  • Simran Grewal,
  • Aytug U. Tirpan,
  • Susanne Eberl,
  • Kak Khee Yeung,
  • Ron Balm,
  • Germaine C. Verwoert,
  • Antoine H. G. Driessen and
  • Robert J. M. Klautz
  • + 1 author

Background: An acute aortic dissection (AAD) is a highly lethal condition that demands immediate medical intervention. Survivors often face significant long-term challenges. While immediate survival remains a critical focus in acute care settings, li...

  • Article
  • Open Access
917 Views
14 Pages

The Cross-Talk Between the Heart and the Liver: The Involvement of the Mitral Valve as a Novel Actor upon the Ancient Scene of Liver Cirrhosis

  • Domenico Cozzolino,
  • Riccardo Nevola,
  • Alberto Ruggiero,
  • Ciro Romano,
  • Giuseppina Rosaria Umano,
  • Ernesto Aitella,
  • Celestino Sardu,
  • Aldo Marrone and
  • Sandro Gentile

Background: To date, little is known about correlations between liver dysfunction and circulatory and cardiac abnormalities (e.g.,: mitral valve, MV) in patients with chronic liver disease (CLD). This study aimed to assess a potential parallelism bet...

  • Article
  • Open Access
1,007 Views
11 Pages

Indications, Management, and Short- and Medium-Term Outcomes of Patients with Chronic Coronary Occlusion Treated with Percutaneous Revascularization—A Single-Center Study

  • Lucia Barbieri,
  • Gabriele Tumminello,
  • Lorenzo Mafrici,
  • Guido Pasero,
  • Luca Mircoli,
  • Federico Colombo,
  • Cecilia Gobbi,
  • Alessandra S. Rizzuto and
  • Stefano Carugo

The diagnosis of chronic total occlusion (CTO), characterized by the complete obstruction of a coronary artery for at least three months, remains challenging and can be entirely asymptomatic. Since the indications for performing a recanalization proc...

  • Article
  • Open Access
1 Citations
1,789 Views
11 Pages

Determinants of Longitudinal Changes in Exercise Blood Pressure in a Population of Young Athletes: The Role of BMI

  • Francesca Battista,
  • Marco Vecchiato,
  • Kiril Chernis,
  • Sara Faggian,
  • Federica Duregon,
  • Nicola Borasio,
  • Sara Ortolan,
  • Giacomo Pucci,
  • Andrea Ermolao and
  • Daniel Neunhaeuserer

AIM: Higher exercise blood pressure in adults correlates with many cardiometabolic markers. The aim of this study was to investigate the main determinants of longitudinal variations in exercise blood pressure in young athletes. METHODS: A longitudina...

  • Article
  • Open Access
2,408 Views
9 Pages

Inappropriate Sinus Tachycardia in Athletes: Could Nutraceuticals Play a Role?

  • Antonio Scarà,
  • Alessio Borrelli,
  • Antonio Gianluca Robles,
  • Sara Burazor,
  • Lorenzo-Lupo Dei,
  • Federico Zanin,
  • Leonardo Pignalosa,
  • Elena Cavarretta,
  • Liuba Fusco and
  • Andrej Pernat
  • + 3 authors

Introduction: Inappropriate sinus tachycardia (IST) is a syndrome characterized by unexpectedly fast and prolonged sinus rates at rest or with minimal physical activity. Epidemiologic characteristics are uncertain, but most patients are young and fem...

  • Case Report
  • Open Access
1,235 Views
11 Pages

Percutaneous treatment of highly thrombotic coronary lesions is demanding, due to worse acute and long-term clinical outcomes. In this report, we describe a case series of six patients with ST-segment elevation myocardial infarction and high-thrombus...

  • Review
  • Open Access
3 Citations
6,786 Views
25 Pages

Arrhythmogenic Right Ventricular Cardiomyopathy: A Comprehensive Review

  • Taha Shaikh,
  • Darren Nguyen,
  • Jasmine K. Dugal,
  • Michael V. DiCaro,
  • Brianna Yee,
  • Nazanin Houshmand,
  • KaChon Lei and
  • Ali Namazi

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by structural abnormalities, arrhythmias, and a spectrum of genetic and clinical manifestations. Clinically, ARVC is structurally distinguished by right ventricular dilation due...

  • Review
  • Open Access
3 Citations
2,610 Views
18 Pages

Applications of Computational Fluid Dynamics in Congenital Heart Disease: A Review

  • Amartya Dave,
  • Raquel dos Santos,
  • Usmaan Siddiqi,
  • Aashi Dharia,
  • Willa Li,
  • Umar Siddiqi,
  • Nhung Nguyen,
  • Luka Pocivavsek and
  • Narutoshi Hibino

Computational fluid dynamics (CFD) is a tool that allows for the analysis of otherwise unobservable blood flow patterns. In the context of medicine, CFD enables researchers to better understand acute and chronic pathophysiology as well as utilize mod...

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J. Cardiovasc. Dev. Dis. - ISSN 2308-3425