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Journal of Cardiovascular Development and Disease, Volume 10, Issue 3

2023 March - 42 articles

Cover Story: Hypoplastic left heart syndrome is a congenital heart condition that requires a series of three surgeries over the first three years of life. In these surgeries, the tricuspid valve of the right side is converted into the regulator of the systemic blood flow. Unfortunately, due to these surgical alterations and the congenital valvular anomalies, these newborns are at risk of developing a retrograde blood flow between the lower and upper chambers in a comorbidity colloquially known as tricuspid regurgitation. In this article, we review the research that has been performed to understand the causes and effects of regurgitation in this unique disease. Additionally, we propose future engineering-focused studies that can improve the diagnosis and treatment techniques. View this paper
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Articles (42)

  • Editorial
  • Open Access
10 Citations
2,974 Views
7 Pages

It has been a long time since, in the spectrum of ischemic (IHD) or coronary (CHD) heart diseases, a differentiation was performed between the forms presenting with and those without pain [...]

  • Article
  • Open Access
4 Citations
2,593 Views
16 Pages

Incidence and Risk Factors for Long-Term Persistence of Diastolic Dysfunction after Aortic Valve Replacement for Aortic Stenosis Compared with Aortic Regurgitation

  • Luminița Iliuță,
  • Andreea Gabriella Andronesi,
  • Alexandru Scafa-Udriște,
  • Bogdan Rădulescu,
  • Horațiu Moldovan,
  • Florentina Ligia Furtunescu and
  • Eugenia Panaitescu

(1) Background: Severe left ventricular (LV) diastolic dysfunction with a restrictive diastolic pattern (LVDFP) is generally associated with a worse prognosis. Its evolution and reversibility in the short- and medium-term after aortic valve replaceme...

  • Article
  • Open Access
7 Citations
2,878 Views
16 Pages

An All-in-One Tool for 2D Atherosclerotic Disease Assessment and 3D Coronary Artery Reconstruction

  • Savvas Kyriakidis,
  • George Rigas,
  • Vassiliki Kigka,
  • Dimitris Zaridis,
  • Georgia Karanasiou,
  • Panagiota Tsompou,
  • Gianna Karanasiou,
  • Lampros Lakkas,
  • Sotirios Nikopoulos and
  • Antonis I. Sakellarios
  • + 3 authors

Diagnosis of coronary artery disease is mainly based on invasive imaging modalities such as X-ray angiography, intravascular ultrasound (IVUS) and optical coherence tomography (OCT). Computed tomography coronary angiography (CTCA) is also used as a n...

  • Case Report
  • Open Access
4 Citations
3,194 Views
9 Pages

Contemporary Management Strategies of Baffle Leaks in Adults with a Failing Systemic Right Ventricle Late after Atrial Switch: A Case Series and Literature Overview

  • Ralph M. L. Neijenhuis,
  • Madelien V. Regeer,
  • Frank van der Kley,
  • Hubert W. Vliegen,
  • Monique R. M. Jongbloed,
  • Philippine Kiès,
  • Martin J. Schalij,
  • J. Wouter Jukema and
  • Anastasia D. Egorova

Baffle leaks are a frequently encountered and often overlooked complication after the atrial switch procedure for transposition of the great arteries. Baffle leaks are present in up to 50% of non-selected patients, and while they initially may not ca...

  • Review
  • Open Access
35 Citations
7,166 Views
20 Pages

The Impact of the Blood Lipids Levels on Arterial Stiffness

  • Mirela Baba,
  • Mihaela Maris,
  • Daniela Jianu,
  • Constantin Tudor Luca,
  • Dana Stoian and
  • Ioana Mozos

Arterial stiffness is a recognized predictor of cardiovascular morbidity and death. It is an early indicator of arteriosclerosis and is influenced by numerous risk factors and biological processes. The lipid metabolism is crucial and standard blood l...

  • Article
  • Open Access
5 Citations
2,853 Views
10 Pages

BioMimics 3D Stent in Femoropopliteal Lesions: 3-Year Outcomes with Propensity Matching for Drug-Coated Balloons

  • Michael Piorkowski,
  • Thomas Zeller,
  • Christos Rammos,
  • Koen Deloose,
  • Klaus Hertting,
  • Volker Sesselmann,
  • Gunnar Tepe,
  • Peter Gaines and
  • Michael Lichtenberg

Background: Through its helical centreline geometry, the BioMimics 3D vascular stent system is designed for the mobile femoropopliteal region, aiming to improve long-term patency and the risk of stent fractures. Methods: MIMICS 3D is a prospective, E...

  • Article
  • Open Access
3 Citations
2,116 Views
12 Pages

Electrocardiographic and other Noninvasive Hemodynamic Markers in Decompensated CHF Patients

  • Gianfranco Piccirillo,
  • Federica Moscucci,
  • Martina Mezzadri,
  • Cristina Caltabiano,
  • Ilaria Di Diego,
  • Myriam Carnovale,
  • Andrea Corrao,
  • Sara Stefano,
  • Claudia Scinicariello and
  • Damiano Magrì
  • + 4 authors

Acutely decompensated chronic heart failure (adCHF) is among the most important causes of in-hospital mortality. R-wave peak time (RpT) or delayed intrinsicoid deflection was proposed as a risk marker of sudden cardiac death and heart failure decompe...

  • Article
  • Open Access
4 Citations
2,810 Views
15 Pages

Impact of Mitral Regurgitation Recurrence on Mitral Valve Repair for Secondary Ischemic Mitral Regurgitation

  • Antonio Salsano,
  • Antonio Nenna,
  • Nicolas Molinari,
  • Sanjeet Singh Avtaar Singh,
  • Cristiano Spadaccio,
  • Francesco Santini,
  • Massimo Chello,
  • Antonio Fiore and
  • Francesco Nappi

Objectives. The current guidelines still do not include specific recommendations on the use of subvalvular repair (SV-r) for treatment of ischemic mitral regurgitation (IMR). Therefore, the objective of our study was to evaluate the clinical impact o...

  • Review
  • Open Access
10 Citations
3,327 Views
38 Pages

The Role of ncRNAs in Cardiac Infarction and Regeneration

  • Sheila Caño-Carrillo,
  • Estefanía Lozano-Velasco,
  • Juan Manuel Castillo-Casas,
  • Cristina Sánchez-Fernández and
  • Diego Franco

Myocardial infarction is the most prevalent cardiovascular disease worldwide, and it is defined as cardiomyocyte cell death due to a lack of oxygen supply. Such a temporary absence of oxygen supply, or ischemia, leads to extensive cardiomyocyte cell...

  • Article
  • Open Access
3 Citations
3,430 Views
13 Pages

Morphological and Functional Remodeling of the Ischemic Heart Correlates with Homocysteine Levels

  • Attila Cziraki,
  • Zoltan Nemeth,
  • Sandor Szabados,
  • Tamas Nagy,
  • Márk Szántó,
  • Csaba Nyakas and
  • Akos Koller

Background: Homocysteine (Hcy) is involved in various methylation processes, and its plasma level is increased in cardiac ischemia. Thus, we hypothesized that levels of homocysteine correlate with the morphological and functional remodeling of ischem...

  • Article
  • Open Access
5 Citations
3,164 Views
14 Pages

Magnetic Resonance Left Ventricle Mass-Index/Fibrosis: Long-Term Predictors for Ventricular Arrhythmia in Hypertrophic Cardiomyopathy—A Retrospective Registry

  • Habib Rehman Khan,
  • Philip Rodwell,
  • Ahmed Hasan Taha,
  • Ahmed Goha,
  • Mobeen Ahmed,
  • Andrew Peter Thain,
  • Konstantinos Somarakis,
  • Ayman Al-Atta,
  • Bara Erhayiem and
  • Thomas Mathew
  • + 1 author

Objective: We aimed to study the long-term association of LV mass index (LVMI) and myocardial fibrosis with ventricular arrhythmia (VA) in a population of patients with confirmed hypertrophic cardiomyopathy (HCM) using cardiac magnetic resonance imag...

  • Article
  • Open Access
5 Citations
2,952 Views
15 Pages

Impact of Insulin-Treated Compared to Non-Insulin-Treated Diabetes Mellitus on Outcome of Percutaneous Coronary Intervention with Drug-Coated Balloons versus Drug-Eluting Stents in De Novo Coronary Artery Disease: The Randomized BASKET-SMALL 2 Trial

  • Julia Seeger,
  • Jochen Wöhrle,
  • Bruno Scheller,
  • Ahmed Farah,
  • Marc-Alexander Ohlow,
  • Norman Mangner,
  • Sven Möbius-Winkler,
  • Daniel Weilenmann,
  • Georg Stachel and
  • on behalf of the BASKET-SMALL 2 Investigators
  • + 6 authors

Background: We evaluated the outcome of PCI of de novo stenosis with drug-coated balloons (DCB) versus drug-eluting stents (DES) in patients with insulin-treated diabetes mellitus (ITDM) versus non-insulin-treated diabetes mellitus (NITDM). Methods:...

  • Review
  • Open Access
4 Citations
3,673 Views
10 Pages

Minimal Access Tricuspid Valve Surgery

  • Jean-Alexandre Sauvé,
  • Yung-Szu Wu,
  • Ravi Ghatanatti and
  • Joseph Zacharias

Tricuspid valve diseases are a heterogeneous group of pathologies that typically have poor prognoses when treated medically and are associated with significant morbidity and mortality with traditional surgical techniques. Minimal access tricuspid val...

  • Article
  • Open Access
5 Citations
4,216 Views
10 Pages

Ischemic Stroke and Savings in Time to Achieve Functional Recovery: Experience from NeuroAiD

  • Narayanaswamy Venketasubramanian,
  • Yogesh Pokharkar,
  • Jia Hui Chai and
  • Christopher Li Hsian Chen

Despite recent progress with revascularisation interventions after acute ischemic stroke, many patients remain disabled after stroke. Using data from a multi-centre, randomised, double-blind, placebo-controlled trial of a neuro-repair treatment (Neur...

  • Systematic Review
  • Open Access
6 Citations
4,370 Views
12 Pages

Effects of Intravenous Iron Replacement Therapy on Cardiovascular Outcomes in Patients with Heart Failure: A Systematic Review and Meta-Analysis

  • Johannes Reinhold,
  • Vyas Burra,
  • Natasha Corballis,
  • Vasiliki Tsampasian,
  • Gareth Matthews,
  • Charikleia Papadopoulou and
  • Vassilios S. Vassiliou

(1) Background: Iron deficiency (ID) is an important adverse prognostic marker in patients with heart failure (HF); however, it is unclear whether intravenous iron replacement reduces cardiovascular mortality in this patient group. Here, we estimate...

  • Article
  • Open Access
2 Citations
2,835 Views
8 Pages

Background: To compare the characteristics of a “real world” population included in a prospective registry to patients enrolled in a randomized, controlled trial (RCT) after endovascular revascularization (EVR) for symptomatic peripheral...

  • Review
  • Open Access
4 Citations
6,902 Views
12 Pages

Heart failure (HF) is a complex clinical syndrome involving structural and/or functional abnormalities of the heart. Heart failure is often classified based on left ventricular ejection fraction, which serves as a predictor of mortality. The majority...

  • Article
  • Open Access
2,313 Views
8 Pages

Impaired Cardiovascular Parameters in Resistance Training Practitioners Who Take Ergogenic Aids

  • Bruno Bavaresco Gambassi,
  • Daniela Conceição Gomes Gonçalves e Silva,
  • Camila Almeida Sá,
  • Roberto Rodrigues Bezerra,
  • Cleilson Barbosa de Freitas,
  • Marcelo Silva Costa,
  • Paulo Roberto da Silva Marques,
  • Pedro Paulo Ramos da Silva,
  • Manoel Pereira Guimarães and
  • Paulo Adriano Schwingel
  • + 3 authors

Background: Although there are studies on blood pressure (BP) and autonomic cardiac control (ACC) impairments caused by ergogenic aids, research has scarcely addressed this analysis during sleep. This study analyzed BP and ACC during sleep and wake p...

  • Article
  • Open Access
5 Citations
4,127 Views
13 Pages

Role of Antiplatelet Therapy in Patients with Severe Coronary Artery Disease Undergoing Coronary Artery Endarterectomy within Coronary Artery Bypass Surgery

  • Ilir Balaj,
  • Heinz Jakob,
  • Ali Haddad,
  • Fanar Mourad,
  • Assad Haneya,
  • Ebrahim Ali,
  • Noura Ryadi,
  • Matthias Thielmann,
  • Arjang Ruhparwar and
  • Sharaf-Eldin Shehada

Background—Coronary endarterectomy (CEA) has been introduced to allow revascularization in end-stage coronary artery disease (CAD). After CEA, the injured remnants of the vessel’s media could result in fast neo intimal tissue ingrowth, which require...

  • Review
  • Open Access
6 Citations
6,873 Views
18 Pages

Tricuspid Valve Regurgitation in Hypoplastic Left Heart Syndrome: Current Insights and Future Perspectives

  • Colton J. Ross,
  • Arshid Mir,
  • Harold M. Burkhart,
  • Gerhard A. Holzapfel and
  • Chung-Hao Lee

Hypoplastic Left Heart Syndrome (HLHS) is a congenital heart defect that requires a three-stage surgical palliation to create a single ventricle system in the right side of the heart. Of patients undergoing this cardiac palliation series, 25% will de...

  • Article
  • Open Access
5 Citations
3,364 Views
15 Pages

BMAL1 Promotes Valvular Interstitial Cells’ Osteogenic Differentiation through NF-κ B/AKT/MAPK Pathway

  • Yefan Jiang,
  • Song Wang,
  • Wenfeng Lin,
  • Jiaxi Gu,
  • Geng Li and
  • Yongfeng Shao

Objectives: Calcific aortic valve disease (CAVD) is most common in the aging population and is without effective medical treatments. Brain and muscle ARNT-like 1 (BMAL1) is related to calcification. It has unique tissue-specific characteristics and p...

  • Article
  • Open Access
13 Citations
3,144 Views
18 Pages

Uncertainty Quantification in the In Vivo Image-Based Estimation of Local Elastic Properties of Vascular Walls

  • Benigno Marco Fanni,
  • Maria Nicole Antonuccio,
  • Alessandra Pizzuto,
  • Sergio Berti,
  • Giuseppe Santoro and
  • Simona Celi

Introduction: Patient-specific computational models are a powerful tool for planning cardiovascular interventions. However, the in vivo patient-specific mechanical properties of vessels represent a major source of uncertainty. In this study, we inves...

  • Article
  • Open Access
2,465 Views
10 Pages

Compared with conventional right ventricular septal pacing (RVSP), several studies have shown a net clinical benefit of left bundle branch area pacing (LBBAP) in terms of ejection fraction preservation and reduced hospitalizations for heart failure....

  • Article
  • Open Access
2 Citations
2,293 Views
15 Pages

Aortic Root Replacement Surgery—A Center Experience with Biological Valve Prostheses

  • Mohamed Salem,
  • Maximilian Boehme,
  • Christine Friedrich,
  • Markus Ernst,
  • Thomas Puehler,
  • Georg Lutter,
  • Felix Schoeneich,
  • Assad Haneya,
  • Jochen Cremer and
  • Jan Schoettler

Objective: Outcomes after surgical aortic root replacement using different valved conduits are rarely reported. The present study shows the experience of a single center with the use of the partially biological LABCOR (LC) conduit and the fully biolo...

  • Communication
  • Open Access
22 Citations
6,619 Views
9 Pages

As heart transplantation continues to be the gold-standard therapy for end-stage heart failure, the supply-demand imbalance of available organs worsens. Until recently, there have been no advances in increasing the donor pool, as prolonged cold ische...

  • Article
  • Open Access
5 Citations
3,230 Views
10 Pages

Genetic Basis of Early Onset Atrial Fibrillation in Patients without Risk Factors

  • Irina Rudaka,
  • Baiba Vilne,
  • Jekaterina Isakova,
  • Oskars Kalejs,
  • Linda Gailite and
  • Dmitrijs Rots

Background: Atrial fibrillation (AF) is the most common arrhythmia and typically occurs in elderly patients with other cardiovascular and extracardiac diseases. However, up to 15% of AF develops without any related risk factors. Recently, the role of...

  • Article
  • Open Access
3 Citations
2,885 Views
13 Pages

Pharmacological Modulation by Low Molecular Weight Heparin of Purinergic Signaling in Cardiac Cells Prevents Arrhythmia and Lethality Induced by Myocardial Infarction

  • Carlos Eduardo Braga Filho,
  • Adriano Henrique Pereira Barbosa,
  • Lucas Antonio Duarte Nicolau,
  • Jand Venes Rolim Medeiros,
  • Marcelo Pires-Oliveira,
  • Rui Manuel dos Santos Póvoa,
  • Tânia Carmen Penãranda Govato,
  • Hézio Jadir Fernandes Júnior,
  • Rafael Guzella de Carvalho and
  • Francisco Sandro Menezes-Rodrigues
  • + 6 authors

Background: Although several studies suggest that heparins prevent arrhythmias caused by acute myocardial infarction (AMI), the molecular mechanisms involved remain unclear. To investigate the involvement of pharmacological modulation of adenosine (A...

  • Article
  • Open Access
1 Citations
2,379 Views
8 Pages

The Effect of Coronavirus Outbreak on the Utilization of Coronary Revascularization Procedures: An Interrupted Time Series Analysis

  • Antonio Sarria-Santamera,
  • Alexandr Petrov,
  • Dinara Yessimova,
  • Miguel A Ortega,
  • Saule Zhumambayeva and
  • Angel Asúnsolo

The coronavirus disease 19 (COVID-19) pandemic represented a great challenge for health systems, which had to quickly readapt and dedicate most of their resources to managing this crisis. The postponement of programmed interventions such as coronary...

  • Article
  • Open Access
3 Citations
2,184 Views
11 Pages

Prevalence and Characteristics of Inspiration-Induced Negative Left Atrial Pressure during Pulmonary Vein Isolation

  • Takenori Ikoma,
  • Yoshihisa Naruse,
  • Yutaro Kaneko,
  • Tomoaki Sakakibara,
  • Taro Narumi,
  • Makoto Sano,
  • Satoshi Mogi,
  • Kenichiro Suwa,
  • Hayato Ohtani and
  • Yuichiro Maekawa
  • + 2 authors

Background: Atrial fibrillation (AF) ablation is performed under deep sedation, which may cause inspiration-induced negative left atrial pressure (INLAP) associated with deep inspiration. INLAP could be the cause of periprocedural complications. Meth...

  • Article
  • Open Access
14 Citations
2,916 Views
14 Pages

Acute and Chronic Changes in Myocardial Work Parameters in Patients with Severe Primary Mitral Regurgitation Undergoing Transcatheter Edge-to-Edge Repair

  • Elena Galli,
  • Pierre Hubert,
  • Guillaume Leurent,
  • Vincent Auffret,
  • Vasileios Panis,
  • Guillaume L’Official and
  • Erwan Donal

Background: The noninvasive assessment of myocardial work (MW) allows for the evaluation of left ventricular (LV) performance by considering the effect of LV afterload. This study aims to evaluate the acute and chronic impact of transcatheter edge-to...

  • Review
  • Open Access
2 Citations
3,158 Views
10 Pages

Hypoplastic left heart syndrome (HLHS) is a complex congenital heart disease characterized by hypoplasia of left-sided heart structures. The developmental basis for restriction of defects to the left side of the heart in HLHS remains unexplained. The...

  • Article
  • Open Access
2,633 Views
12 Pages

A Pilot Trial to Compare the Long-Term Efficacy of Pulmonary Vein Isolation with High-Power Short-Duration Radiofrequency Versus Laser Energy with Rapid Ablation Mode

  • Sönke Schildt,
  • Sabine Fredersdorf,
  • Carsten G. Jungbauer,
  • Christian Hauck,
  • Daniel Tarnowski,
  • Kurt Debl,
  • Stefan Neef,
  • Christian Schach,
  • Samuel Sossalla and
  • Ekrem Üçer
  • + 1 author

Background: Pulmonary vein (PV) reconnection is the major cause of atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI). The probability of reconnection is higher if the primary lesion is not sufficiently effective, which can be u...

  • Communication
  • Open Access
5 Citations
2,322 Views
8 Pages

CPVT and Complete Atrio-Ventricular Block: The Flipside of the Same Coin

  • Mattia Petrungaro,
  • Antonio Scarà,
  • Alessio Borrelli and
  • Luigi Sciarra

Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is a rare electrical genetic disease characterized by ventricular polymorphic tachycardia and/or bidirectional ventricular tachycardia induced by the release of catecholamines caused by int...

  • Review
  • Open Access
1 Citations
2,264 Views
10 Pages

Longitudinal Outcomes Following Surgical Repair of Primary Mitral Regurgitation

  • Yuan Qiu,
  • Hiroki Takaya,
  • Kay Maeda,
  • David Messika-Zeitoun,
  • Marc Ruel,
  • Thierry Mesana and
  • Vincent Chan

Degenerative mitral valve (MV) disease is the most common cause of organic mitral regurgitation (MR) in developed countries. Surgical mitral valve repair is the gold standard treatment for primary MR. Surgical mitral valve repair is associated with e...

  • Review
  • Open Access
12 Citations
4,439 Views
16 Pages

The treatment of patients with aortic valve calcification (AVC) and calcific aortic valve stenosis (CAVS) remains challenging as, until today, all non-invasive interventions have proven fruitless in preventing the disease’s onset and progressio...

  • Review
  • Open Access
22 Citations
32,904 Views
16 Pages

The Effect of a Vegan Diet on the Cardiovascular System

  • Michail Koutentakis,
  • Stanisław Surma,
  • Sylwester Rogula,
  • Krzysztof J. Filipiak and
  • Aleksandra Gąsecka

The vegan diet, often known as a plant-rich diet, consists primarily of plant-based meals. This dietary approach may be beneficial to one’s health and the environment and is valuable to the immune system. Plants provide vitamins, minerals, phyt...

  • Systematic Review
  • Open Access
5 Citations
3,435 Views
17 Pages

Appropriateness of Percutaneous Coronary Interventions: A Systematic Review and Meta-Analysis

  • Yijie Liu,
  • Yuxiong Chen,
  • Zhen’ge Chang,
  • Yitao Han,
  • Siqi Tang,
  • Yakun Zhao,
  • Jia Fu,
  • Yanbo Liu and
  • Zhongjie Fan

Background: Since the foundation of appropriate use criteria (AUC) for coronary revascularization, the proportion of inappropriate (later revised as “rarely inappropriate”) percutaneous coronary interventions (PCIs) varied in different po...

  • Systematic Review
  • Open Access
4 Citations
2,993 Views
7 Pages

Percutaneous Coronary Intervention Outcomes in Patients with Liver Cirrhosis: A Systematic Review and Meta-Analysis

  • Harshwardhan Khandait,
  • Vikash Jaiswal,
  • Muhammad Hanif,
  • Abhigan Babu Shrestha,
  • Alisson Iturburu,
  • Maitri Shah,
  • Angela Ishak,
  • Vamsi Garimella,
  • Song Peng Ang and
  • Midhun Mathew

There is a paucity of data and minimal literature on outcomes of percutaneous coronary intervention (PCI) among liver cirrhosis patients. Therefore, we conducted a systematic review and meta-analysis to evaluate the clinical outcomes among liver cirr...

  • Systematic Review
  • Open Access
9 Citations
3,883 Views
12 Pages

Association between Genetic Variants of CELSR2-PSRC1-SORT1 and Cardiovascular Diseases: A Systematic Review and Meta-Analysis

  • Rosa Giannina Castillo-Avila,
  • Thelma Beatriz González-Castro,
  • Carlos Alfonso Tovilla-Zárate,
  • José Jaime Martínez-Magaña,
  • María Lilia López-Narváez,
  • Isela Esther Juárez-Rojop,
  • Pedro Iván Arias-Vázquez,
  • Verónica Marusa Borgonio-Cuadra,
  • Nonanzit Pérez-Hernández and
  • José Manuel Rodríguez-Pérez

A cluster of three genes CELSR2, PSRC1, and SORT1 has been associated with cardiovascular diseases. Thus, the aim of this study was (i) to perform a systematic review and updated meta-analysis of the association of three polymorphisms (rs646776, rs59...

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J. Cardiovasc. Dev. Dis. - ISSN 2308-3425