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Medicines, Volume 6, Issue 4

December 2019 - 20 articles

Cover Story: TRAIL exhibits cancer-cell‐specific killing effects or promotes cancer cell survival through inducing NF‐kB. In combination treatment with TRAIL, glucosamine increases the flux toward apoptosis versus survival/inflammation. The addition of glucosamine and TRAIL activates both the extrinsic and intrinsic apoptotic pathways while reducing NF‐kB levels which are typically stimulated by TRAIL treatment alone. These confocal microscopy images demonstrate the translocation of BAK to the mitochondrial outer membrane, triggering the intrinsic apoptosis pathway. This combination treatment provides a potential strategy for treating glucosamine‐sensitive cancers by disturbing the TRAIL‐induced apoptosis and survival balance. View this paper.
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Articles (20)

  • Letter
  • Open Access
10 Citations
5,727 Views
7 Pages

16 December 2019

Background: The objective of this pilot study was to evaluate the cerebral effects of laser stimulation and traditional needle acupuncture in patients after stroke. Methods: Seventeen stroke patients (12 female and five male; mean age ± SD: 66...

  • Article
  • Open Access
2 Citations
4,205 Views
8 Pages

Proteomic and Phosphoproteomic Analysis Reveals that Neurokinin-1 Receptor (NK1R) Blockade with Aprepitant in Human Keratinocytes Activates a Distinct Subdomain of EGFR Signaling: Implications for the Anti-Pruritic Activity of NK1R Antagonists

  • Shawn G. Kwatra,
  • Emily Boozalis,
  • Amy H. Huang,
  • Cory Nanni,
  • Raveena Khanna,
  • Kyle A. Williams,
  • Yevgeniy R. Semenov,
  • Callie M. Roberts,
  • Robert F. Burns and
  • Madan M. Kwatra

9 December 2019

Background: Epidermal growth factor receptor (EGFR) inhibitors can cause serious cutaneous toxicities, including pruritus and papulopustular acneiform skin eruptions. Increasingly, the neurokinin-1 receptor (NK1R) antagonist aprepitant is being utili...

  • Article
  • Open Access
11 Citations
4,875 Views
12 Pages

22 November 2019

Background: Blepharis linariifolia Pers. (Family: Acanthaceae) is used in traditional medicines as a general tonic and for the treatment of various health problems in Sudan. The main aim of this study was to isolate and identify the major chemical co...

  • Case Report
  • Open Access
11 Citations
7,021 Views
8 Pages

15 November 2019

Sweet’s syndrome is an uncommon skin disease characterized by painful polymorphic lesions associated with fever and neutrophilia. When biopsied, these lesions reveal a diffuse infiltrate of mature neutrophils in the papillary dermis. Several dr...

  • Perspective
  • Open Access
7 Citations
4,953 Views
7 Pages

Itch in Chronic Wounds: Pathophysiology, Impact, and Management

  • Michela Iannone,
  • Agata Janowska,
  • Valentina Dini,
  • Giulia Tonini,
  • Teresa Oranges and
  • Marco Romanelli

15 November 2019

Background: The aims of this review are to analyze the current literature regarding the characteristics and pathophysiological mechanisms of itch in chronic wounds, to assess the impact on quality of life and delayed-healing, to focus on the best str...

  • Article
  • Open Access
8 Citations
5,710 Views
8 Pages

Role of Dysregulated Ion Channels in Sensory Neurons in Chronic Kidney Disease-Associated Pruritus

  • Akishi Momose,
  • Micihihiro Yabe,
  • Shigetoshi Chiba,
  • Kenjirou Kumakawa,
  • Yasuo Shiraiwa and
  • Hiroki Mizukami

13 November 2019

Background: We investigated ion channels at the skin, including peripheral nerve endings, which serve as output machines and molecular integrators of many pruritic inputs mainly received by multiple G protein-coupled receptors (GPCRs). Methods: Based...

  • Article
  • Open Access
35 Citations
5,244 Views
15 Pages

Acute Kidney Injury in Patients Undergoing Cardiac Transplantation: A Meta-Analysis

  • Charat Thongprayoon,
  • Ploypin Lertjitbanjong,
  • Panupong Hansrivijit,
  • Anthony Crisafio,
  • Michael A. Mao,
  • Kanramon Watthanasuntorn,
  • Narothama Reddy Aeddula,
  • Tarun Bathini,
  • Wisit Kaewput and
  • Wisit Cheungpasitporn

1 November 2019

Background: Acute kidney injury (AKI) is a common complication following solid-organ transplantation. However, the epidemiology of AKI and mortality risk of AKI among patients undergoing cardiac transplantation is not uniformly described. We conducte...

  • Article
  • Open Access
19 Citations
4,501 Views
12 Pages

Acute Kidney Injury in Pediatric Patients on Extracorporeal Membrane Oxygenation: A Systematic Review and Meta-analysis

  • Panupong Hansrivijit,
  • Ploypin Lertjitbanjong,
  • Charat Thongprayoon,
  • Wisit Cheungpasitporn,
  • Narothama Reddy Aeddula,
  • Sohail Abdul Salim,
  • Api Chewcharat,
  • Kanramon Watthanasuntorn,
  • Narat Srivali and
  • Tarun Bathini
  • + 3 authors

1 November 2019

Background: Acute kidney injury (AKI) is a well-established complication of extra-corporal membrane oxygenation (ECMO) in the adult population. The data in the pediatric and neonatal population is still limited. Moreover, the mortality risk of AKI am...

  • Review
  • Open Access
4 Citations
5,427 Views
22 Pages

A Unique Formulation of Cardioprotective Bio-Actives: An Overview of Their Safety Profile

  • William Salminen,
  • Mayowa Agbaje-Williams and
  • Funmilayo O. Ajayi

22 October 2019

The burden of cardiovascular disease (CVD) remains high globally and in the United States despite the availability of pharmaceuticals aimed at its prevention and treatment. An invention by Summit Innovation Labs, which is a formula consisting of a un...

  • Perspective
  • Open Access
7 Citations
9,091 Views
7 Pages

Erythrina suberosa: Ethnopharmacology, Phytochemistry and Biological Activities

  • Felicia Patti,
  • Yasaman Taheri,
  • Javad Sharifi-Rad,
  • Miquel Martorell,
  • William C. Cho and
  • Raffaele Pezzani

18 October 2019

Plants are a great and irreplaceable source of medicines, fuel, food, energy and even cosmetics. Since prehistory, humans have learned to use plants for survival, growth and proliferation and still today it relies on natural and cultivated vegetables...

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Medicines - ISSN 2305-6320