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Medicines, Volume 6, Issue 4 (December 2019) – 20 articles
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Cover Story (view full-size image) TRAIL exhibits cancer-cell‐specific killing effects or promotes cancer cell survival through [...] Read more. TRAIL exhibits cancer-cell‐specific killing effects or promotes cancer cell survival through inducing NF‐kB. In combination treatment with TRAIL, glucosamine increases the flux toward apoptosis versus survival/inflammation. The addition of glucosamine and TRAIL activates both the extrinsic and intrinsic apoptotic pathways while reducing NF‐kB levels which are typically stimulated by TRAIL treatment alone. These confocal microscopy images demonstrate the translocation of BAK to the mitochondrial outer membrane, triggering the intrinsic apoptosis pathway. This combination treatment provides a potential strategy for treating glucosamine‐sensitive cancers by disturbing the TRAIL‐induced apoptosis and survival balance. View this paper.