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Open AccessArticle

Antipyretic, Antinociceptive, and Anti-Inflammatory Activities from Pogostemon benghalensis Leaf Extract in Experimental Wister Rats

Department of Pharmacy, Universal College of Medical Sciences, Tribhuvan University, Bhairahawa, Rupandehi 32900, Nepal
Department of Natural Products Research, Dr. Koirala Research Institute for Biotechnology and Biodiversity, Kathmandu 44600, Nepal
Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
Department of Pharmacy, Purbanchal University College of Medical and Allied Sciences, Biratnagar, Morang 56613, Nepal
Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, Iran
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT 84043, USA
Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol 61615–585, Iran
Department of Civil and Environmental Engineering, Faculty of Science and Technology, University of Macau, Macau SAR 999078, China
Authors to whom correspondence should be addressed.
Medicines 2019, 6(4), 96;
Received: 22 August 2019 / Revised: 7 September 2019 / Accepted: 9 September 2019 / Published: 20 September 2019
(This article belongs to the Special Issue Biological Potential and Medical Use of Natural Extracts)
Background: Pogostemon benghalensis leaves have traditionally been utilized for relieving body aches, headaches and fever. Based on its uses, the present study was designed to investigate the antinociceptive, antipyretic and anti-edematogenic activities from P. benghalensis leaves’ methanol extract (PBME) in Wister rats. Methods: The thermal (hot plate) and chemical (acetic acid-induced writhing and formalin test) models for antinociceptive effects, and the Brewer’s yeast induced hyperthermia test for antipyretic action and rat paw edema by carrageenan for anti-edematogenic activity, were applied for PBME at different dose levels. The acute toxicity of PBME through the oral route was performed to determine the lethal dose. Results: PBME significantly and dose-dependently reduced pyrexia and diminished edema volume, which depicted its antipyretic and anti-edematogenic effects respectively. The inhibition of writhing reflex, increased reaction latency and reduced frequency of licking indicated that PBME has significant dose-dependent antinociceptive activity. P. benghalensis methanol extract at 4000 mg/kg shows no sign of toxicity, which is a considerable, good margin of safety. Conclusions: The study illustrated the antipyretic, antinociceptive and anti-inflammatory potential of P. benghalensis leaf extract with a safety margin, and validated its traditional use to alleviate fever, pain, and inflammation. View Full-Text
Keywords: Pogostemon benghalensis; antipyretic; antinociceptive; anti-inflammatory; PBME; methanolic extract Pogostemon benghalensis; antipyretic; antinociceptive; anti-inflammatory; PBME; methanolic extract
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Aryal, S.; Adhikari, B.; Panthi, K.; Aryal, P.; Mallik, S.K.; Bhusal, R.P.; Salehi, B.; Setzer, W.N.; Sharifi-Rad, J.; Koirala, N. Antipyretic, Antinociceptive, and Anti-Inflammatory Activities from Pogostemon benghalensis Leaf Extract in Experimental Wister Rats. Medicines 2019, 6, 96.

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