Next Article in Journal
Diagnostic Workup and Evaluation of Patients with Prurigo Nodularis
Next Article in Special Issue
In Vitro Anti-Inflammatory and Immunomodulatory Activities of an Extract from the Roots of Bupleurum rotundifolium
Previous Article in Journal
Dietary Supplements on Controlling Multiple Sclerosis Symptoms and Relapses: Current Clinical Evidence and Future Perspectives
Previous Article in Special Issue
Comprehensive Fractionation of Antioxidants and GC-MS and ESI-MS Fingerprints of Celastrus hindsii Leaves
Open AccessArticle

Antipyretic, Antinociceptive, and Anti-Inflammatory Activities from Pogostemon benghalensis Leaf Extract in Experimental Wister Rats

1
Department of Pharmacy, Universal College of Medical Sciences, Tribhuvan University, Bhairahawa, Rupandehi 32900, Nepal
2
Department of Natural Products Research, Dr. Koirala Research Institute for Biotechnology and Biodiversity, Kathmandu 44600, Nepal
3
Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
4
Department of Pharmacy, Purbanchal University College of Medical and Allied Sciences, Biratnagar, Morang 56613, Nepal
5
Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, Iran
6
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
7
Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT 84043, USA
8
Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol 61615–585, Iran
9
Department of Civil and Environmental Engineering, Faculty of Science and Technology, University of Macau, Macau SAR 999078, China
*
Authors to whom correspondence should be addressed.
Medicines 2019, 6(4), 96; https://doi.org/10.3390/medicines6040096
Received: 22 August 2019 / Revised: 7 September 2019 / Accepted: 9 September 2019 / Published: 20 September 2019
(This article belongs to the Special Issue Biological Potential and Medical Use of Natural Extracts)
Background: Pogostemon benghalensis leaves have traditionally been utilized for relieving body aches, headaches and fever. Based on its uses, the present study was designed to investigate the antinociceptive, antipyretic and anti-edematogenic activities from P. benghalensis leaves’ methanol extract (PBME) in Wister rats. Methods: The thermal (hot plate) and chemical (acetic acid-induced writhing and formalin test) models for antinociceptive effects, and the Brewer’s yeast induced hyperthermia test for antipyretic action and rat paw edema by carrageenan for anti-edematogenic activity, were applied for PBME at different dose levels. The acute toxicity of PBME through the oral route was performed to determine the lethal dose. Results: PBME significantly and dose-dependently reduced pyrexia and diminished edema volume, which depicted its antipyretic and anti-edematogenic effects respectively. The inhibition of writhing reflex, increased reaction latency and reduced frequency of licking indicated that PBME has significant dose-dependent antinociceptive activity. P. benghalensis methanol extract at 4000 mg/kg shows no sign of toxicity, which is a considerable, good margin of safety. Conclusions: The study illustrated the antipyretic, antinociceptive and anti-inflammatory potential of P. benghalensis leaf extract with a safety margin, and validated its traditional use to alleviate fever, pain, and inflammation. View Full-Text
Keywords: Pogostemon benghalensis; antipyretic; antinociceptive; anti-inflammatory; PBME; methanolic extract Pogostemon benghalensis; antipyretic; antinociceptive; anti-inflammatory; PBME; methanolic extract
Show Figures

Graphical abstract

MDPI and ACS Style

Aryal, S.; Adhikari, B.; Panthi, K.; Aryal, P.; Mallik, S.K.; Bhusal, R.P.; Salehi, B.; Setzer, W.N.; Sharifi-Rad, J.; Koirala, N. Antipyretic, Antinociceptive, and Anti-Inflammatory Activities from Pogostemon benghalensis Leaf Extract in Experimental Wister Rats. Medicines 2019, 6, 96.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop