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Article

Antipyretic, Antinociceptive, and Anti-Inflammatory Activities from Pogostemon benghalensis Leaf Extract in Experimental Wister Rats

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Department of Pharmacy, Universal College of Medical Sciences, Tribhuvan University, Bhairahawa, Rupandehi 32900, Nepal
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Department of Natural Products Research, Dr. Koirala Research Institute for Biotechnology and Biodiversity, Kathmandu 44600, Nepal
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Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia
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Department of Pharmacy, Purbanchal University College of Medical and Allied Sciences, Biratnagar, Morang 56613, Nepal
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Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, Iran
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Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
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Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT 84043, USA
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Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol 61615–585, Iran
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Department of Civil and Environmental Engineering, Faculty of Science and Technology, University of Macau, Macau SAR 999078, China
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Authors to whom correspondence should be addressed.
Medicines 2019, 6(4), 96; https://doi.org/10.3390/medicines6040096
Received: 22 August 2019 / Revised: 7 September 2019 / Accepted: 9 September 2019 / Published: 20 September 2019
(This article belongs to the Special Issue Biological Potential and Medical Use of Natural Extracts)
Background: Pogostemon benghalensis leaves have traditionally been utilized for relieving body aches, headaches and fever. Based on its uses, the present study was designed to investigate the antinociceptive, antipyretic and anti-edematogenic activities from P. benghalensis leaves’ methanol extract (PBME) in Wister rats. Methods: The thermal (hot plate) and chemical (acetic acid-induced writhing and formalin test) models for antinociceptive effects, and the Brewer’s yeast induced hyperthermia test for antipyretic action and rat paw edema by carrageenan for anti-edematogenic activity, were applied for PBME at different dose levels. The acute toxicity of PBME through the oral route was performed to determine the lethal dose. Results: PBME significantly and dose-dependently reduced pyrexia and diminished edema volume, which depicted its antipyretic and anti-edematogenic effects respectively. The inhibition of writhing reflex, increased reaction latency and reduced frequency of licking indicated that PBME has significant dose-dependent antinociceptive activity. P. benghalensis methanol extract at 4000 mg/kg shows no sign of toxicity, which is a considerable, good margin of safety. Conclusions: The study illustrated the antipyretic, antinociceptive and anti-inflammatory potential of P. benghalensis leaf extract with a safety margin, and validated its traditional use to alleviate fever, pain, and inflammation. View Full-Text
Keywords: Pogostemon benghalensis; antipyretic; antinociceptive; anti-inflammatory; PBME; methanolic extract Pogostemon benghalensis; antipyretic; antinociceptive; anti-inflammatory; PBME; methanolic extract
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MDPI and ACS Style

Aryal, S.; Adhikari, B.; Panthi, K.; Aryal, P.; Mallik, S.K.; Bhusal, R.P.; Salehi, B.; Setzer, W.N.; Sharifi-Rad, J.; Koirala, N. Antipyretic, Antinociceptive, and Anti-Inflammatory Activities from Pogostemon benghalensis Leaf Extract in Experimental Wister Rats. Medicines 2019, 6, 96. https://doi.org/10.3390/medicines6040096

AMA Style

Aryal S, Adhikari B, Panthi K, Aryal P, Mallik SK, Bhusal RP, Salehi B, Setzer WN, Sharifi-Rad J, Koirala N. Antipyretic, Antinociceptive, and Anti-Inflammatory Activities from Pogostemon benghalensis Leaf Extract in Experimental Wister Rats. Medicines. 2019; 6(4):96. https://doi.org/10.3390/medicines6040096

Chicago/Turabian Style

Aryal, Sushant, Balkrishna Adhikari, Kasmira Panthi, Pramod Aryal, Shyam K. Mallik, Ram P. Bhusal, Bahare Salehi, William N. Setzer, Javad Sharifi-Rad, and Niranjan Koirala. 2019. "Antipyretic, Antinociceptive, and Anti-Inflammatory Activities from Pogostemon benghalensis Leaf Extract in Experimental Wister Rats" Medicines 6, no. 4: 96. https://doi.org/10.3390/medicines6040096

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