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Article

The UHPLC-QTOF-MS Phenolic Profiling and Activity of Cydonia oblonga Mill. Reveals a Promising Nutraceutical Potential

1
Department for Sustainable Food Process, Università Cattolica del Sacro Cuore, Via Emilia Parmense 84, 29122 Piacenza, Italy
2
Department of Biology, Science Faculty, Selcuk University, Campus, Konya 42130, Turkey
3
Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr el-Aini Street, Cairo 11562, Egypt
4
Department of Pharmacy, University Federico II of Naples, Via D. Montesano 49, 80131 Naples, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Oscar Núñez
Foods 2021, 10(6), 1230; https://doi.org/10.3390/foods10061230
Received: 10 May 2021 / Revised: 25 May 2021 / Accepted: 26 May 2021 / Published: 28 May 2021
(This article belongs to the Special Issue Foodomics: New Approaches to Evaluate Food Quality)
Cydonia oblonga Mill., normally known as the quince fruit, has been widely used in agro-food industries mainly to produce jams and jellies. However, other parts of the plants are still underutilized and not completely assessed for their nutraceutical profile. Therefore, in this work, the polyphenolic profile of C. oblonga was investigated using an untargeted metabolomics approach based on high-resolution mass spectrometry. Several compounds were identified in the different parts of the plants, including flavonoids (i.e., anthocyanins, flavones, flavan-3-ols, and flavonols), phenolic acids (both hydroxycinnamics and hydroxybenzoics), low-molecular-weight phenolics (tyrosol equivalents), lignans, and stilbenes. Overall, C. oblonga leaves showed the highest in vitro antioxidant potential, as revealed by 2,2-difenil-1-picrylhydrazyl (DPPH), 2,2′-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), ferric reducing antioxidant power (FRAP), and cupric ion reducing antioxidant capacity (CUPRAC) assays, being 189.5, 285.6, 158.9, and 348.8 mg Trolox Equivalent/g, respectively. The enzymes acetyl- and butyryl-cholinesterases were both inhibited by the different plant parts of C. oblonga, with stems showing the higher inhibitory potential. Interestingly, the fruit extracts were the only parts inhibiting the α-glucosidase, with a value of 1.36 mmol acarbose equivalents (ACAE)/g. On the other hand, strong tyrosinase inhibition was found for stems and leaves, being 72.11 and 68.32 mg Kojic acid Equivalent/g, respectively. Finally, a high number of significant (0.05 < p < 0.01) correlations were outlined between phenolics (mainly anthocyanins, flava-3-ols, and tyrosol equivalents) and the different biological assays. Taken together, our findings suggest a potential exploitation of C. oblonga leaves and stems for the food, pharmaceutical, and cosmetic industries. View Full-Text
Keywords: Cydonia oblonga; nutraceuticals; polyphenols; foodomics; antioxidants; enzyme inhibitions Cydonia oblonga; nutraceuticals; polyphenols; foodomics; antioxidants; enzyme inhibitions
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MDPI and ACS Style

Zhang, L.; Rocchetti, G.; Zengin, G.; Ak, G.; Saber, F.R.; Montesano, D.; Lucini, L. The UHPLC-QTOF-MS Phenolic Profiling and Activity of Cydonia oblonga Mill. Reveals a Promising Nutraceutical Potential. Foods 2021, 10, 1230. https://doi.org/10.3390/foods10061230

AMA Style

Zhang L, Rocchetti G, Zengin G, Ak G, Saber FR, Montesano D, Lucini L. The UHPLC-QTOF-MS Phenolic Profiling and Activity of Cydonia oblonga Mill. Reveals a Promising Nutraceutical Potential. Foods. 2021; 10(6):1230. https://doi.org/10.3390/foods10061230

Chicago/Turabian Style

Zhang, Leilei, Gabriele Rocchetti, Gökhan Zengin, Gunes Ak, Fatema R. Saber, Domenico Montesano, and Luigi Lucini. 2021. "The UHPLC-QTOF-MS Phenolic Profiling and Activity of Cydonia oblonga Mill. Reveals a Promising Nutraceutical Potential" Foods 10, no. 6: 1230. https://doi.org/10.3390/foods10061230

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